Peptide ligands to explore interactions with intrinsically disordered multidomain proteins: the case of SARS-CoV-2 nucleocapsid protein

This article explores synthetic peptide ligands targeting the intrinsically disordered regions of the SARS-CoV-2 nucleocapsid protein. Using NMR spectroscopy, molecular dynamics, and circular dichroism, the study shows how peptide sequence and flexibility influence binding affinity. The results support a modular peptide design strategy for targeting complex proteins, with potential applications in antiviral research.