Ultramicronized N-palmitoylethanolamine (PEA) in vivo delays morphine tolerance with mechanisms that are still unclear. Ultramicronized PEA down-modulated both morphine-induced MC degranulation and the expression of inflammatory and pain-related genes from astrocytes challenged with RBL-2H3 medium, suggesting that PEA may delay morphine tolerance, regulating MC-astrocyte crosstalk.
Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance / Toti A, Micheli L, Lucarini E, Ferrara V, Ciampi C, Margiotta F, Failli P, Pallecchi M, Bartolucci G, Ghelardini C, Di Cesare Mannelli L.. - In: BIOMOLECULES. - ISSN 2218-273X. - ELETTRONICO. - (2023), pp. 0-0. [10.3390/biom13020233]
Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance
Toti AInvestigation
;Micheli LInvestigation
;Lucarini EInvestigation
;Ferrara VInvestigation
;Ciampi CInvestigation
;Margiotta FInvestigation
;Failli PConceptualization
;Pallecchi MConceptualization
;Bartolucci GConceptualization
;Ghelardini CConceptualization
;Di Cesare Mannelli L.
Conceptualization
2023
Abstract
Ultramicronized N-palmitoylethanolamine (PEA) in vivo delays morphine tolerance with mechanisms that are still unclear. Ultramicronized PEA down-modulated both morphine-induced MC degranulation and the expression of inflammatory and pain-related genes from astrocytes challenged with RBL-2H3 medium, suggesting that PEA may delay morphine tolerance, regulating MC-astrocyte crosstalk.
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