On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles

Chimichi, Stefano; Boccalini, Marco; Selleri, Silvia; Costagli, C.; Guerrini, Gabriella; Viola, G.

doi:10.1039/b717835b

Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained.

trova@unifi

Titolo:	On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles
Autori di Ateneo:	CHIMICHI, STEFANO BOCCALINI, MARCO SELLERI, SILVIA C. Costagli GUERRINI, GABRIELLA G. Viola mostra contributor esterni nascondi contributor esterni
Autori:	CHIMICHI, STEFANO; BOCCALINI, MARCO; SELLERI, SILVIA; C. Costagli; GUERRINI, GABRIELLA; G. Viola
Data di pubblicazione:	2008
Rivista:	ORGANIC & BIOMOLECULAR CHEMISTRY
Volume:	6
Pagina iniziale:	739
Pagina finale:	744
Abstract:	Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained.
Handle:	http://hdl.handle.net/2158/344491
Appare nelle tipologie:	1a - Articolo su rivista

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