Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained.
Titolo: | On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles |
Autori di Ateneo: | |
Autori: | CHIMICHI, STEFANO; BOCCALINI, MARCO; SELLERI, SILVIA; C. Costagli; GUERRINI, GABRIELLA; G. Viola |
Data di pubblicazione: | 2008 |
Rivista: | |
Volume: | 6 |
Pagina iniziale: | 739 |
Pagina finale: | 744 |
Abstract: | Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained. |
Handle: | http://hdl.handle.net/2158/344491 |
Appare nelle tipologie: | 1a - Articolo su rivista |
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