Cell migration is necessary for proper embryonic development and adult tissue remodeling. Its mechanisms determine the physiopathology of processes such as neuronal targeting, inflammation, wound healing and metastatic spread. Crawling of cells onto solid surfaces requires a controlled sequence of cell protrusions and retractions that mainly depends on sophisticated regulation of the actin cytoskeleton, although the contribution of microtubules should not be neglected. This process is triggered and modulated by a combination of diffusible and fixed environmental signals. External cues are sensed and integrated by membrane receptors, including integrins, which transduce these signals into cellular signaling pathways, often centered on the small GTPase proteins belonging to the Rho family. These pathways regulate the coordinated cytoskeletal rearrangements necessary for proper timing of adhesion, contraction and detachement at the front and rear side of cells finding their way through the extracellular spaces. The overall process involves continuous modulation of cell motility, shape and volume, in which ion channels play major roles. In particular, Ca2+ signals have both global and local regulatory effects on cell motility, because they target the contractile proteins as well as many regulatory proteins.

Integrins and ion channels in cell migration: implications for neuronal development, wound healing and metastatic spread / A.Becchetti; A.Arcangeli. - STAMPA. - (2010), pp. 107-123. [10.1007/978-1-4419-6066-5_10]

Integrins and ion channels in cell migration: implications for neuronal development, wound healing and metastatic spread.

ARCANGELI, ANNAROSA
2010

Abstract

Cell migration is necessary for proper embryonic development and adult tissue remodeling. Its mechanisms determine the physiopathology of processes such as neuronal targeting, inflammation, wound healing and metastatic spread. Crawling of cells onto solid surfaces requires a controlled sequence of cell protrusions and retractions that mainly depends on sophisticated regulation of the actin cytoskeleton, although the contribution of microtubules should not be neglected. This process is triggered and modulated by a combination of diffusible and fixed environmental signals. External cues are sensed and integrated by membrane receptors, including integrins, which transduce these signals into cellular signaling pathways, often centered on the small GTPase proteins belonging to the Rho family. These pathways regulate the coordinated cytoskeletal rearrangements necessary for proper timing of adhesion, contraction and detachement at the front and rear side of cells finding their way through the extracellular spaces. The overall process involves continuous modulation of cell motility, shape and volume, in which ion channels play major roles. In particular, Ca2+ signals have both global and local regulatory effects on cell motility, because they target the contractile proteins as well as many regulatory proteins.
2010
978-144196065-8
Integrins and Ion Channels: Molecular Complexes and Signaling
107
123
A.Becchetti; A.Arcangeli
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/432526
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