Enhanced receptor selectivity: Carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m) Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3) ] (Cp=cyclopentadienyl, M=Re, (99m) Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported.
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http://hdl.handle.net/2158/776369
Titolo: | [(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX. |
Autori di Ateneo: | |
Autori: | D. Can; B. Spingler; P. Schmutz; F. Mendes; P. Raposinho; C. Fernandes; CARTA, FABRIZIO; A. Innocenti; I. Santos; SUPURAN, CLAUDIU TRANDAFIR; R. Alberto |
Anno di registrazione: | 2012 |
Rivista: | ANGEWANDTE CHEMIE. INTERNATIONAL EDITION |
Volume: | 51 |
Pagina iniziale: | 3354 |
Pagina finale: | 3357 |
Abstract: | Enhanced receptor selectivity: Carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m) Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3) ] (Cp=cyclopentadienyl, M=Re, (99m) Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported. |
Handle: | http://hdl.handle.net/2158/776369 |
Appare nelle tipologie: | 1a - Articolo su rivista |
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