Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties.
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors / M. Bozdag, T. Dreker, C. Henry, P. Tosco, M. Vallaro, R. Fruttero, A. Scozzafava, F. Carta, C. T. Supuran. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 23:(2012), pp. 715-719.
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
SCOZZAFAVA, ANDREA;CARTA, FABRIZIO;SUPURAN, CLAUDIU TRANDAFIR
2012
Abstract
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties.
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