The effect of mutations of two different sarcomeric proteins, cardiac troponin T (cTnT) and skeletal nebuline on biophysical properties of crossbridge cicle on myofibrils were investigated. Mechanical and kinetic properties of myofibrils from a human cardiac and a neonatal skeletal murine biopsies, were analized and explained using the same 2-state model of acto-myosin interaction proposed by Brenner in 1988.
Impact of sarcomeric protein mutations associated to myopathies on the mechanics and energetics of myofibril contraction / Claudia Ferrara. - STAMPA. - (2013).
Impact of sarcomeric protein mutations associated to myopathies on the mechanics and energetics of myofibril contraction
FERRARA, CLAUDIA
2013
Abstract
The effect of mutations of two different sarcomeric proteins, cardiac troponin T (cTnT) and skeletal nebuline on biophysical properties of crossbridge cicle on myofibrils were investigated. Mechanical and kinetic properties of myofibrils from a human cardiac and a neonatal skeletal murine biopsies, were analized and explained using the same 2-state model of acto-myosin interaction proposed by Brenner in 1988.
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