The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53). They could be best defined as apoptosis-related genes, a definition that stresses the importance of apoptosis (and of its dysregulation) in the genesis and development of cancer in humans and other species. Dysregulation of apoptosis is involved also in the development of diseases other that cancer, such as autoimmune diseases, AIDS and various degenerative pathologies.
BCL-2 / M. Ruggiero. - STAMPA. - (2009), pp. 309-312. [10.1007/978-3-540-47648-1_562]
BCL-2
RUGGIERO, MARCO
2009
Abstract
The Bcl2 family of proteins belong to a peculiar class of proteins regulating apoptosis, cell cycle, differentiation, and autophagy; in oncology, the genes coding for these proteins could not be defined neither as dominant transforming oncogenes (such as myc), nor tumor suppressor genes (such as p53). They could be best defined as apoptosis-related genes, a definition that stresses the importance of apoptosis (and of its dysregulation) in the genesis and development of cancer in humans and other species. Dysregulation of apoptosis is involved also in the development of diseases other that cancer, such as autoimmune diseases, AIDS and various degenerative pathologies.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.