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|Titolo:||Endogenous serotonin facilitates hippocampal long-term potentiation at CA3/CA1 synapses|
|Autori interni:||MLINAR, BORIS|
|Data di pubblicazione:||2015|
|Rivista:||JOURNAL OF NEURAL TRANSMISSION|
|Abstract:||Abstract: Encoding of episodic memory requires long-term potentiation (LTP) of neurotransmission at excitatory synapses of the hippocampal circuitry. Previous data obtained with the application of exogenous 5-hydroxytryptamine (5-HT) in hippocampal slices indicate that 5-HT blocks LTP, which contrasts with the facilitatory effect of selective serotonin reuptake inhibitors (SSRIs) on learning and memory observed in vivo. Here, we investigated the effects of endogenous 5-HT, released from terminals by the monoamine releaser 3,4-methylenedioxymethamphetamine (MDMA), on LTP of field EPSPs induced by theta-burst stimulation and recorded at CA3/CA1 synapses of rat hippocampal slices. LTP was greater in the presence of MDMA (10 lM; 45.76 ± 15.75 %; n = 28) than in controls (31.26 ± 11.03; n = 21; p\0.01). This facilitatory effect on LTP persisted when the entry ofMDMAin noradrenergic terminals was prevented by the selective noradrenaline reuptake inhibitor nisoxetine (44.90 ± 14.07 %; n = 27 vs. 34.49 ± 12.94 %; n = 20 in controls; p\0.05). In both conditions, the facilitation of LTP was abolished by the SSRI citalopram that prevented the entry of MDMA in 5-HT terminals and the subsequent 5-HT release. These data show that, unlike exogenous 5-HT application, release of endogenous 5-HT does not impair cellular mechanisms responsible for induction of LTP, indicating that 5-HT is not detrimental to learning and memory. Moreover, facilitation of LTP by endogenous 5-HT may underlie the in vivo positive effects of augmented 5-HT tone on cognitive performance.|
|Appare nelle tipologie:||1a - Articolo su rivista|
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