GIOVANNUZZI, SIMONE
GIOVANNUZZI, SIMONE
Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA)
. Synthesis, characterization and biological activity evaluation of a dual-drug based on the antibacterial peptide lugdunin functionalized with the carbonic anhydrase sulfonamide inhibitor acetazolamide
2024 M. Quagliata; F. Brenzini Biagioni; S. Giovannuzzi; V. De Luca; C. Capasso; A. Nocentini; C.T. Supuran; P. Rovero; A.M. Papini
1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities
2023 Elsawi, Ahmed E.; Elbadawi, Mostafa M.; Nocentini, Alessio; Almahli, Hadia; Giovannuzzi, Simone; Shaldam, Moataz; Salem, Rofaida; Ibrahim, Tamer M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; Eldehna, Wagdy M.
2-(Piperidin-1-yl)-N-(4-sulfamoylphenyl)acetamide derivatives as novel inhibitors of cancer-associated carbonic anhydrase isoforms IX and XII
2025 Eldehna, Wagdy M.; Elbadawi, Mostafa M.; Elsayed, Zainab M.; Giovannuzzi, Simone; Elkotamy, Mahmoud S.; Elsawi, Ahmed E.; Ahmed, Saleh A.; Rashed, Mahmoud; Nocentini, Alessio; Supuran, Claudiu T.; Abdel-Aziz, Hatem A.
4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors
2022 Abdoli, Morteza; Giovannuzzi, Simone; Supuran, Claudiu T; Žalubovskis, Raivis
Aromatic sulfonamides including a sulfonic acid tail: New membrane impermeant carbonic anhydrase inhibitors for targeting selectively the cancer‐associated isoforms
2022 Giovannuzzi S.; D'ambrosio M.; Luceri C.; Osman S.M.; Pallecchi M.; Bartolucci G.; Nocentini A.; Supuran C.T.
Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity
2024 Giovannuzzi S.; Nikitjuka A.; Angeli A.; Smietana M.; Massardi M.-L.; Turati M.; Ronca R.; Bonardi A.; Nocentini A.; Ferraroni M.; Supuran C.T.; Winum J.-Y.
Boron-containing carbonic anhydrases inhibitors
2024 Giovannuzzi, Simone; Nikitjuka, Anna; Pereira Resende, Bruna Rafaela; Smietana, Michael; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves
Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors
2023 Martínez-Montiel, Mónica; Romero-Hernández, Laura L; Giovannuzzi, Simone; Begines, Paloma; Puerta, Adrián; Ahuja-Casarín, Ana I; Fernandes, Miguel X; Merino-Montiel, Penélope; Montiel-Smith, Sara; Nocentini, Alessio; Padrón, José M; Supuran, Claudiu T; Fernández-Bolaños, José G; López, Óscar
Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII
2022 Giovannuzzi, Simone; Capasso, Clemente; Nocentini, Alessio; Supuran, Claudiu T
Coumarins effectively inhibit bacterial α-carbonic anhydrases
2022 Giovannuzzi S.; Hewitt C.S.; Nocentini A.; Capasso C.; Flaherty D.P.; Supuran C.T.
Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
2022 Giovannuzzi S.; De Luca V.; Nocentini A.; Capasso C.; Supuran C.T.
Coumarin–Thiourea Hybrids: Structural Features Governing CA Inhibition and Antiproliferative Effects
2026 Fuentes-Aguilar, Alma; Colombo, Rebecca; González-Bakker, Aday; Puerta, Adrián; Merino-Montiel, Penélope; Montiel-Smith, Sara; Vega-Báez, José L.; Giovannuzzi, Simone; Nocentini, Alessio; Fernández-Bolaños, José G.; Supuran, Claudiu T.; Padrón, José M.; López, Óscar
Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors
2025 Abdel-dayem, Shymaa I.A.; Otify, Asmaa M.; Iannotti, Fabio Arturo; Saber, Fatema R.; Moriello, Aniello Schiano; Giovannuzzi, Simone; Świątek, Łukasz; Bonardi, Alessandro; Gratteri, Paola; Skalicka-Woźniak, Krystyna; Supuran, Claudiu T.
Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity
2026 Roshdy, Eslam; Kilic, Ahmet; Mustafa, Muhamad; Celik, Ismail; Sarı, Zeynep Betül; Simsek, Ender; Nocentini, Alessio; Giovannuzzi, Simone; Supuran, Claudiu T.; Özensoy Güler, Özen; Winum, Jean-Yves; Abe, Manabu
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies
2023 Begines, Paloma; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Giovannuzzi, Simone; Ronca, Roberto; Tavani, Camilla; Luisa Massardi, Maria; López, Óscar; Supuran, Claudiu T
Development of isatin-functionalized benzenesulfonamides as novel carbonic anhydrase II and VII inhibitors with antiepileptic potential
2025 Eldehna, Wagdy M.; El-Hamaky, Anwar A.; Giovannuzzi, Simone; Elsayed, Zainab M.; Alkabbani, Mahmoud Abdelrahman; Khaleel, Eman F.; Al-Sanea, Mohammad M.; Abo-Ashour, Mahmoud F.; Elnaggar, Yosra S.R.; Nocentini, Alessio; Supuran, Claudiu T.; Tawfik, Haytham O.
Development of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity
2025 Elkotamy, Mahmoud S.; Abdelrahman, Mohamed A.; Giovannuzzi, Simone; Alkabbani, Mahmoud Abdelrahman; Nocentini, Alessio; Supuran, Claudiu T.; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.; Abou-Seri, Sahar M.
Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases
2026 Nocentini, Alessio; Giovannuzzi, Simone; Alterio, Vincenzo; Bonardi, Alessandro; Barons, Rudolfs; Zalubovskis, Raivis; Eldehna, Wagdy M.; Aronne, Rossella; Esposito, Davide; Luchinat, Enrico; De Simone, Giuseppina; Bartolucci, Gianluca; Gratteri, Paola; Mori, Mattia; Supuran, Claudiu T.
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties
2023 Saied, Samaa; Shaldam, Moataz; Elbadawi, Mostafa M.; Giovannuzzi, Simone; Nocentini, Alessio; Almahli, Hadia; Salem, Rofaida; Ibrahim, Tamer M.; Supuran, Claudiu T.; Eldehna, Wagdy M.
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
2023 Giovannuzzi, Simone; Bonardi, Alessandro; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| . Synthesis, characterization and biological activity evaluation of a dual-drug based on the antibacterial peptide lugdunin functionalized with the carbonic anhydrase sulfonamide inhibitor acetazolamide | 2024 | M. Quagliata; F. Brenzini Biagioni; S. Giovannuzzi; V. De Luca; C. Capasso; A. Nocentini; C.T. Supuran; P. Rovero; A.M. Papini | |
| 1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities | 2023 | Elsawi, Ahmed E.; Elbadawi, Mostafa M.; Nocentini, Alessio; Almahli, Hadia; Giovannuzzi, Simone; Shaldam, Moataz; Salem, Rofaida; Ibrahim, Tamer M.; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.; Eldehna, Wagdy M. | |
| 2-(Piperidin-1-yl)-N-(4-sulfamoylphenyl)acetamide derivatives as novel inhibitors of cancer-associated carbonic anhydrase isoforms IX and XII | 2025 | Eldehna, Wagdy M.; Elbadawi, Mostafa M.; Elsayed, Zainab M.; Giovannuzzi, Simone; Elkotamy, Mahmoud S.; Elsawi, Ahmed E.; Ahmed, Saleh A.; Rashed, Mahmoud; Nocentini, Alessio; Supuran, Claudiu T.; Abdel-Aziz, Hatem A. | |
| 4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors | 2022 | Abdoli, Morteza; Giovannuzzi, Simone; Supuran, Claudiu T; Žalubovskis, Raivis | |
| Aromatic sulfonamides including a sulfonic acid tail: New membrane impermeant carbonic anhydrase inhibitors for targeting selectively the cancer‐associated isoforms | 2022 | Giovannuzzi S.; D'ambrosio M.; Luceri C.; Osman S.M.; Pallecchi M.; Bartolucci G.; Nocentini A.; Supuran C.T. | |
| Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity | 2024 | Giovannuzzi S.; Nikitjuka A.; Angeli A.; Smietana M.; Massardi M.-L.; Turati M.; Ronca R.; Bonardi A.; Nocentini A.; Ferraroni M.; Supuran C.T.; Winum J.-Y. | |
| Boron-containing carbonic anhydrases inhibitors | 2024 | Giovannuzzi, Simone; Nikitjuka, Anna; Pereira Resende, Bruna Rafaela; Smietana, Michael; Nocentini, Alessio; Supuran, Claudiu T.; Winum, Jean-Yves | |
| Conformationally Restricted Glycoconjugates Derived from Arylsulfonamides and Coumarins: New Families of Tumour-Associated Carbonic Anhydrase Inhibitors | 2023 | Martínez-Montiel, Mónica; Romero-Hernández, Laura L; Giovannuzzi, Simone; Begines, Paloma; Puerta, Adrián; Ahuja-Casarín, Ana I; Fernandes, Miguel X; Merino-Montiel, Penélope; Montiel-Smith, Sara; Nocentini, Alessio; Padrón, José M; Supuran, Claudiu T; Fernández-Bolaños, José G; López, Óscar | |
| Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII | 2022 | Giovannuzzi, Simone; Capasso, Clemente; Nocentini, Alessio; Supuran, Claudiu T | |
| Coumarins effectively inhibit bacterial α-carbonic anhydrases | 2022 | Giovannuzzi S.; Hewitt C.S.; Nocentini A.; Capasso C.; Flaherty D.P.; Supuran C.T. | |
| Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum | 2022 | Giovannuzzi S.; De Luca V.; Nocentini A.; Capasso C.; Supuran C.T. | |
| Coumarin–Thiourea Hybrids: Structural Features Governing CA Inhibition and Antiproliferative Effects | 2026 | Fuentes-Aguilar, Alma; Colombo, Rebecca; González-Bakker, Aday; Puerta, Adrián; Merino-Montiel, Penélope; Montiel-Smith, Sara; Vega-Báez, José L.; Giovannuzzi, Simone; Nocentini, Alessio; Fernández-Bolaños, José G.; Supuran, Claudiu T.; Padrón, José M.; López, Óscar | |
| Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors | 2025 | Abdel-dayem, Shymaa I.A.; Otify, Asmaa M.; Iannotti, Fabio Arturo; Saber, Fatema R.; Moriello, Aniello Schiano; Giovannuzzi, Simone; Świątek, Łukasz; Bonardi, Alessandro; Gratteri, Paola; Skalicka-Woźniak, Krystyna; Supuran, Claudiu T. | |
| Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity | 2026 | Roshdy, Eslam; Kilic, Ahmet; Mustafa, Muhamad; Celik, Ismail; Sarı, Zeynep Betül; Simsek, Ender; Nocentini, Alessio; Giovannuzzi, Simone; Supuran, Claudiu T.; Özensoy Güler, Özen; Winum, Jean-Yves; Abe, Manabu | |
| Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies | 2023 | Begines, Paloma; Bonardi, Alessandro; Nocentini, Alessio; Gratteri, Paola; Giovannuzzi, Simone; Ronca, Roberto; Tavani, Camilla; Luisa Massardi, Maria; López, Óscar; Supuran, Claudiu T | |
| Development of isatin-functionalized benzenesulfonamides as novel carbonic anhydrase II and VII inhibitors with antiepileptic potential | 2025 | Eldehna, Wagdy M.; El-Hamaky, Anwar A.; Giovannuzzi, Simone; Elsayed, Zainab M.; Alkabbani, Mahmoud Abdelrahman; Khaleel, Eman F.; Al-Sanea, Mohammad M.; Abo-Ashour, Mahmoud F.; Elnaggar, Yosra S.R.; Nocentini, Alessio; Supuran, Claudiu T.; Tawfik, Haytham O. | |
| Development of pyrazolo[1,5-a]pyrimidine-grafted coumarins as selective carbonic anhydrase inhibitors and tubulin polymerization inhibitors with potent anticancer activity | 2025 | Elkotamy, Mahmoud S.; Abdelrahman, Mohamed A.; Giovannuzzi, Simone; Alkabbani, Mahmoud Abdelrahman; Nocentini, Alessio; Supuran, Claudiu T.; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.; Abou-Seri, Sahar M. | |
| Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases | 2026 | Nocentini, Alessio; Giovannuzzi, Simone; Alterio, Vincenzo; Bonardi, Alessandro; Barons, Rudolfs; Zalubovskis, Raivis; Eldehna, Wagdy M.; Aronne, Rossella; Esposito, Davide; Luchinat, Enrico; De Simone, Giuseppina; Bartolucci, Gianluca; Gratteri, Paola; Mori, Mattia; Supuran, Claudiu T. | |
| Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties | 2023 | Saied, Samaa; Shaldam, Moataz; Elbadawi, Mostafa M.; Giovannuzzi, Simone; Nocentini, Alessio; Almahli, Hadia; Salem, Rofaida; Ibrahim, Tamer M.; Supuran, Claudiu T.; Eldehna, Wagdy M. | |
| Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors | 2023 | Giovannuzzi, Simone; Bonardi, Alessandro; Gratteri, Paola; Nocentini, Alessio; Supuran, Claudiu T |