COLOTTA, VITTORIA
 Distribuzione geografica
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Continente #
NA - Nord America 6.083
EU - Europa 3.569
AS - Asia 1.021
AF - Africa 32
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 3
SA - Sud America 2
Totale 10.716
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Nazione #
US - Stati Uniti d'America 6.066
IE - Irlanda 826
SE - Svezia 726
IT - Italia 576
PL - Polonia 447
VN - Vietnam 400
UA - Ucraina 307
HK - Hong Kong 274
DE - Germania 230
CN - Cina 197
FI - Finlandia 145
GB - Regno Unito 144
JO - Giordania 79
ES - Italia 33
FR - Francia 33
RU - Federazione Russa 33
TR - Turchia 26
SC - Seychelles 24
CH - Svizzera 22
NL - Olanda 20
CA - Canada 17
IN - India 14
KR - Corea 11
BE - Belgio 9
AT - Austria 6
EE - Estonia 6
EU - Europa 6
SG - Singapore 5
IL - Israele 4
JP - Giappone 4
NA - Namibia 4
IR - Iran 3
NZ - Nuova Zelanda 3
CZ - Repubblica Ceca 2
DK - Danimarca 2
SA - Arabia Saudita 2
ZA - Sudafrica 2
AR - Argentina 1
BR - Brasile 1
EG - Egitto 1
GE - Georgia 1
IS - Islanda 1
ME - Montenegro 1
MU - Mauritius 1
TH - Thailandia 1
Totale 10.716
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Città #
Fairfield 845
Dublin 825
Chandler 647
Ashburn 563
Jacksonville 457
Warsaw 445
Cambridge 404
Dong Ket 398
Seattle 392
Woodbridge 373
Wilmington 340
Houston 285
Princeton 181
Ann Arbor 158
Boston 137
Hong Kong 128
Altamura 127
Beijing 116
Florence 106
Lawrence 106
Boardman 74
Medford 72
Shanghai 51
San Diego 46
West Jordan 40
Buffalo 39
New York 32
Norwalk 27
Milan 23
Philadelphia 22
Barcelona 21
Bern 20
Moscow 20
Auburn Hills 17
Falls Church 17
Hillsboro 17
Washington 16
Izmir 14
Toronto 14
Frankfurt Am Main 13
Ferrara 12
Andover 11
Gavirate 10
Brussels 9
Camerino 9
Dearborn 9
Rome 9
Salerno 9
Verona 9
Bremen 8
Cagliari 6
Lappeenranta 6
Laurel 6
Los Angeles 6
Pune 6
Tallinn 6
Vienna 6
Bury St Edmunds 5
Catania 5
Cavarzere 5
Dalmine 5
Düsseldorf 5
Groningen 5
Jinan 5
London 5
Mataró 5
Phoenix 5
Redwood City 5
Amsterdam 4
Grevenbroich 4
Mountain View 4
Padova 4
Parma 4
Pontassieve 4
Venice 4
Windhoek 4
Auckland 3
Dallas 3
Grottammare 3
Hefei 3
Nanjing 3
Panzano in Chianti 3
Salt Lake City 3
San Jose 3
Tel Aviv 3
Anguillara Sabazia 2
Asciano 2
Atlanta 2
Avellino 2
Bari 2
Bhubaneswar 2
Boskovice 2
Caserta 2
Chicago 2
Cislago 2
Edinburgh 2
Falkenstein 2
Fiesole 2
Figline Valdarno 2
Frankfurt am Main 2
Totale 7.909
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Nome #
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. 214
Adenosine A2B receptors stimulation inhibits oligodendrocyte maturation by interacting with sphingosine kinase/sphingosine 1-phosphate signalling axis in primary purified oligodendrocyte cultures 200
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists. 169
Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists. 169
The 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold to Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological and Ligand-Receptor Modeling Studies. 162
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype 160
“1,2,4-TRIAZOLO[1,5-A]QUINOXALINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AS ADENOSINE RECEPTOR ANTAGONISTS” 142
1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships 138
1,3-DIARYLPYRAZOLO[4,5-C]- AND -[5,4-C]QUINOLIN-4-ONES. 4. SYNTHESIS AND SPECIFIC INHIBITION OF BENZODIAZEPINE RECEPTOR BINDING. 135
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives. 121
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles 117
Inhibition of A2Aadenosine receptor signaling in cancer cells proliferation by the novel antagonist TP455 106
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes 104
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation and molecular modeling study 102
1,2,4-Triazolo[4,3-a]pyrazin-3-one as a new scaffold to develop potent adenosine receptor antagonists 101
1,2,4-triazolo[4,3-a]quinoxalin-1-one as a framework to obtain potent and selective A1, A2A and A3 adenosine receptor antagonists 100
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists 99
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold to obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition† 99
Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus 98
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation 97
SYNTHESIS, BINDING STUDIES, AND STRUCTURE ACTIVITY RELATIONSHIPS OF 1-ARYL- AND 2-ARYL[1]BENZOPYRANOPYRAZOL-4-ONES, CENTRAL BENZODIAZEPINE RECEPTOR LIGANDS. 96
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII 95
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity 94
Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. 92
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-CYCLOALKYLAMINO-1,2,4-TRIAZOLO[4,3-A]QUINOXALIN-1-ONE DERIVATIVES AS A1 AND A3 ADENOSINE RECEPTOR ANTAGONISTS. 92
A comprehensive strategy in the development of a cyclodextrin-modified microemulsion electrokinetic chromatographic method for the assay of diclofenac and its impurities: Mixture-process variable experiments and quality by design 90
SYNTHESIS OF 1,5-DIARYL-3-METHYL-1H-PYRAZOLO[4,5-C]ISOQUINOLINES AND STUDIES OF BINDING TO SPECIFIC PERIPHERAL BENZODIAZEPINE BINDING SITES. 90
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones. Excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity 90
null 90
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: synthesis and structure-activity relationships 89
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain 89
4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors. 89
TRICYCLIC HETEROAROMATIC SYSTEMS. 5H-1,2,3-TRIAZOLO[5,1-C][1,4]BENZODIAZEPINE. 88
TRICYCLIC HETEROAROMATIC SYSTEMS. SYNTHESIS AND A1 AND A2A ADENOSINE BINDING ACTIVITIES OF SOME 1-ARYL-1,4-DIHYDRO-3-METHYL[1]BENZOPYRANO[2,3-C]PYRAZOL-4-ONES, 1-ARYL-4,9-DIHYDRO-3-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-4-ONES, AND 1-ARYL-1H-IMIDAZO[4,5-B]QUINOXALINES. 88
Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and –imidazol-4-ones. 88
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies. 88
“3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists” 87
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists 87
Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity. 87
Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies 86
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists. 85
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 85
SYNTHESIS OF SOME 2-ARYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONES AS TOOLS TO DEFINE THE ESSENTIAL PHARMACOPHORIC DESCRIPTORS OF A BENZODIAZEPINE RECEPTOR LIGAND. 84
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 1-AMINOPHTHALAZINIUM SALTS AS GABAA RECEPTOR ANTAGONISTS. 84
TRICYCLIC HETEROAROMATIC SYSTEMS. 5H-1,2,4-TRIAZOLO[5,1-C][1,4]BENZODIAZEPINE. 84
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists 84
Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines. 84
Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway 83
STRUCTURE-ACTIVITY RELATIONSHIPS OF 1,2,4-TRIAZOLO[1,5-A]QUINOXALINES AND THEIR 1-DEAZA ANALOGS IMIDAZO[1,2-A]QUINOXALINES AT THE BENZODIAZEPINE RECEPTOR. 82
TRICYCLIC HETEROCYCLIC SYSTEMS: PYRAZOLO[5',4':4,5]- AND PYRAZOLO[3',4':4,5]PYRANO[2,3-B]PYRIDINE DERIVATIVES. 82
1-(3-Aminophenyl)-3-methyl[1]benzopyrano[2,3-c]pyrazol-4-one: a new selective A2 adenosine receptor antagonist. 82
TRICYCLIC HETEROAROMATIC SYSTEMS. 1,2,4-TRIAZOLO[1,5-A]QUINOXALINE. 81
Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity 81
2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists 81
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies. 81
Synthesis and Pharmacological Studies at the Gly/NMDA, AMPA and Kainate Receptors of New Oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring 80
Development of novel pyridazinone-based adenosine receptor ligands 80
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. 80
Competitive AMPA receptor antagonists. 79
SYNTHESIS AND BINDING STUDY OF PYRAZOLO[4,5-C][1,8]NAPHTHYRIDINES. 79
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors. 79
New 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 77
4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as New Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 76
Competitive Gly/NMDA receptor antagonists 75
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies 75
TRICYCLIC HETEROAROMATIC SYSTEMS. [1]BENZOPYRANOPYRROL-4-ONES AND [1]BENZOPYRANO-1,2,3-TRIAZOL-4-ONES AS BENZODIAZEPINE RECEPTOR LIGANDS. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS. 74
Scouting Human A3 Adenosine Receptor Antagonist Binding Mode Using a Molecular Simplification Approach: From Triazoloquinoxaline to a Pyrimidine Skeleton as a Key Study 74
Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity. 73
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies 73
TRICYCLIC HETEROAROMATIC SYSTEMS: [1]BENZOPYRANOPYRAZOL-4-ONES AS BENZODIAZEPINE RECEPTOR LIGANDS. 71
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity 71
Tandem 3D-QSARs Approach as a Valuable Tool To Predict Binding Affinity Data: Design of New Gly/NMDA Receptor Antagonists as a Key Study. 70
THE CORRECT SYNTHESIS OF 2,3-DIHYDRO-2-ARYL-4-R-[1]BENZOPYRANO[4,3-C]PYRAZOLE-3-ONES. 70
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 69
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors 69
Nuovi tiazoli[5,4-d]pirimidin derivati quali agonisti inversi dei recettori A2A dell'adenosina 69
Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists. 68
Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity. 68
Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity. 67
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation 67
Synthesis and Structure-Activity Relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 67
Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site. 65
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists. 64
NOVEL ADENOSINE RECEPTOR LIGANDS: 1,3-DISUBSTITUTED[1]BENZOPYRANO[2,3-C]PYRAZOL-4-ONES. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS. 63
Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A2A adenosine receptor antagonists. 63
Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies 63
Acylsilane-mediated nucleophilic acylation of alfa,beta-unsaturated carbonyl derivatives 62
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies 62
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists 62
Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents 62
TRICYCLIC HETEROAROMATIC SYSTEMS. 1,2,3,4-TETRAHYDROPYRAZOLO[4,3-C][1]BENZAZEPIN-1-ONES AS POTENTIAL ANTITUMOR AGENTS. 61
TRICYCLIC HETEROAROMATIC SYSTEMS: SYNTHESIS, [3H]FLUNITRAZEPAM BRAIN MEMBRANE BINDING INHIBITION, AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 2,3-DIHYDRO-2-ARYL-4-R-[1]BENZOPYRANO[4,3-C]PYRAZOL-3-ONES. 61
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells 59
REACTION OF 1-AMINOPHTHALAZINES WITH A-HALOCARBONYL COMPOUNDS: IMIDAZO-2,1-A]PHTHALAZINES AND THEIR BENZODIAZEPINE RECEPTOR ACTIVITIES. 58
TRICYCLIC HETEROAROMATIC SYSTEMS PYRAZOLO[1,5-A]QUINOXALINES: SYNTHESIS AND BENZODIAZEPINE RECEPTOR ACTIVITY. 57
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2Breceptor 57
G protein-coupled receptors as potential drug target: from receptor topology to rational drug design, an in silico approach 55
Amino-3, 5-dicyanopyridines targeting the adenosine receptors. Ranging from pan ligands to combined A1/A2B partial agonists 54
Tricyclic heteroaromatic systems. Synthesis and benzodiazepine binding activity of 1-substituted-3-methyl- and 3-phenylpyrazolo[4,5-c]quinolin-4-ones. 53
2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists 52
Totale 8.704
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Categoria #
all - tutte 32.386
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.386
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019730 0 0 0 0 0 0 0 0 0 142 316 272
2019/20202.093 170 163 42 201 204 258 208 267 188 143 198 51
2020/20211.824 117 89 131 140 48 184 42 130 126 211 92 514
2021/20221.081 53 124 70 56 34 39 37 72 45 52 186 313
2022/20232.832 270 431 139 189 229 524 414 169 305 16 95 51
2023/20241.193 56 117 191 55 54 329 57 197 38 99 0 0
Totale 10.913