The increase in the incidence of neurodegenerative diseases, in particular Alzheimer's Disease (AD), is a consequence of the world's population aging but unfortunately, existing treatments are only effective at delaying some of the symptoms and for a limited time. Despite huge efforts by both academic researchers and pharmaceutical companies, no disease-modifying drugs have been brought to the market in the last decades. Recently, several studies shed light on Carbonic Anhydrases (CAs, EC 4.2.1.1) as possible new targets for AD treatment. In the present review we summarized preclinical and clinical findings regarding the role of CAs and their inhibitors/activators on cognition, aging and neurodegeneration and we discuss future challenges and opportunities in the field.

A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease / Gustavo Provensi, Fabrizio Carta, Alessio Nocentini, Claudiu T. Supuran, Fiorella Casamenti, Maria Beatrice Passani, Silvia Fossati. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 20:(2019), pp. 4724-4741. [10.3390/ijms20194724]

A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease

Gustavo Provensi
;
Fabrizio Carta;Alessio Nocentini;Claudiu T. Supuran;Fiorella Casamenti;Maria Beatrice Passani;
2019

Abstract

The increase in the incidence of neurodegenerative diseases, in particular Alzheimer's Disease (AD), is a consequence of the world's population aging but unfortunately, existing treatments are only effective at delaying some of the symptoms and for a limited time. Despite huge efforts by both academic researchers and pharmaceutical companies, no disease-modifying drugs have been brought to the market in the last decades. Recently, several studies shed light on Carbonic Anhydrases (CAs, EC 4.2.1.1) as possible new targets for AD treatment. In the present review we summarized preclinical and clinical findings regarding the role of CAs and their inhibitors/activators on cognition, aging and neurodegeneration and we discuss future challenges and opportunities in the field.
2019
20
4724
4741
Goal 3: Good health and well-being for people
Gustavo Provensi, Fabrizio Carta, Alessio Nocentini, Claudiu T. Supuran, Fiorella Casamenti, Maria Beatrice Passani, Silvia Fossati
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1173770
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