In response to the COVID-19 pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a step-wise manner, monitoring of COVID-19 prevalence is of importance to guide decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r=-0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before wide-spread testing can be facilitated.
Relationship between odor intensity estimates and COVID-19 prevalence prediction in a Swedish population / Iravani, Behzad; Arshamian, Artin; Ravia, Aharon; Mishor, Eva; Snitz, Kobi; Shushan, Sagit; Roth, Yehudah; Perl, Ofer; Honigstein, Danielle; Weissgross, Reut; Karagach, Shiri; Ernst, Gernot; Okamoto, Masako; Mainen, Zachary; Monteleone, Erminio; Dinnella, Caterina; Spinelli, Sara; Mariño-Sánchez, Franklin; Ferdenzi, Camille; Smeets, Monique; Touhara, Kazushige; Bensafi, Moustafa; Hummel, Thomas; Sobel, Noam; Lundström, Johan N;. - In: CHEMICAL SENSES. - ISSN 0379-864X. - ELETTRONICO. - bjaa034:(2020), pp. 0-0. [10.1093/chemse/bjaa034]
Relationship between odor intensity estimates and COVID-19 prevalence prediction in a Swedish population
Monteleone, Erminio;Dinnella, Caterina;Spinelli, Sara;
2020
Abstract
In response to the COVID-19 pandemic, countries have implemented various strategies to reduce and slow the spread of the disease in the general population. For countries that have implemented restrictions on its population in a step-wise manner, monitoring of COVID-19 prevalence is of importance to guide decision on when to impose new, or when to abolish old, restrictions. We are here determining whether measures of odor intensity in a large sample can serve as one such measure. Online measures of how intense common household odors are perceived and symptoms of COVID-19 were collected from 2440 Swedes. Average odor intensity ratings were then compared to predicted COVID-19 population prevalence over time in the Swedish population and were found to closely track each other (r=-0.83). Moreover, we found that there was a large difference in rated intensity between individuals with and without COVID-19 symptoms and number of symptoms was related to odor intensity ratings. Finally, we found that individuals progressing from reporting no symptoms to subsequently reporting COVID-19 symptoms demonstrated a large drop in olfactory performance. These data suggest that measures of odor intensity, if obtained in a large and representative sample, can be used as an indicator of COVID-19 disease in the general population. Importantly, this simple measure could easily be implemented in countries without widespread access to COVID-19 testing or implemented as a fast early response before wide-spread testing can be facilitated.File | Dimensione | Formato | |
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