The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases

The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical diseases, that is, Chagas disease and leishmaniasis.