BONARDI, ALESSANDRO
 Distribuzione geografica
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Continente #
NA - Nord America 2.538
EU - Europa 1.549
AS - Asia 612
OC - Oceania 25
AF - Africa 19
SA - Sud America 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.746
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Nazione #
US - Stati Uniti d'America 2.532
RU - Federazione Russa 796
IT - Italia 254
HK - Hong Kong 232
PL - Polonia 158
IE - Irlanda 156
SG - Singapore 139
IN - India 78
SE - Svezia 74
CN - Cina 71
DE - Germania 26
ID - Indonesia 26
AU - Australia 25
GB - Regno Unito 23
JO - Giordania 23
FI - Finlandia 21
UA - Ucraina 13
CI - Costa d'Avorio 9
JP - Giappone 8
KR - Corea 8
NL - Olanda 8
PK - Pakistan 8
EG - Egitto 7
VN - Vietnam 7
CA - Canada 6
ES - Italia 5
CH - Svizzera 4
FR - Francia 4
TW - Taiwan 4
BG - Bulgaria 2
IR - Iran 2
KE - Kenya 2
BE - Belgio 1
BR - Brasile 1
CO - Colombia 1
EU - Europa 1
GE - Georgia 1
GR - Grecia 1
HU - Ungheria 1
IQ - Iraq 1
LT - Lituania 1
RS - Serbia 1
SA - Arabia Saudita 1
SC - Seychelles 1
TJ - Tagikistan 1
TR - Turchia 1
UZ - Uzbekistan 1
Totale 4.746
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Città #
Santa Clara 1.231
Hong Kong 186
Fairfield 184
Warsaw 156
Dublin 154
Ashburn 118
Singapore 117
Chandler 107
Houston 68
Seattle 68
Woodbridge 68
Mumbai 60
Lawrence 59
Cambridge 56
Moscow 56
Altamura 54
Florence 52
Wilmington 51
Princeton 33
Boston 29
Jakarta 26
Melbourne 24
Ann Arbor 19
Kent 18
Rome 17
London 15
Beijing 14
Helsinki 14
Frankfurt am Main 11
Phoenix 11
Sesto Fiorentino 11
West Jordan 11
Yubileyny 11
New York 10
Shanghai 10
Abidjan 9
Medford 9
San Diego 9
Boardman 7
Dong Ket 7
Lappeenranta 7
Milan 7
Chaoyang 6
Naples 6
Norwalk 6
Toronto 6
Buffalo 5
Chandigarh 5
Bern 4
Cagliari 4
Falls Church 4
Gavirate 4
Hanover 4
Irpin 4
Washington 4
Andover 3
Cairo 3
Chak Forty-two SP 3
Chicago 3
Falkenstein 3
Garden City 3
Guangzhou 3
Hillsboro 3
Karachi 3
Los Angeles 3
Lund 3
Redwood City 3
Salamanca 3
Seoul 3
Siena 3
Tokyo 3
Amsterdam 2
Anantapur 2
Bucha 2
Cascina 2
Castelliri 2
Chengdu 2
Delhi 2
Galluccio 2
Hangzhou 2
Inzai 2
Jiaxing 2
Ludhiana 2
Madrid 2
Marseille 2
Multan 2
Nagpur 2
Nanjing 2
Osaka 2
Pune 2
Recanati 2
San Benedetto del Tronto 2
Scandicci 2
Stargard 2
Taichung 2
Turin 2
Varna 2
Wuhan 2
Aigaleo 1
Arezzo 1
Totale 3.350
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Nome #
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform 204
Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights 157
In silico strategies for the rational design, synthesis, and biological evaluation of ligands targeting macromolecules of pharmaceutical interest 157
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 148
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors 136
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 126
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction 119
N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis 112
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action 111
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats 111
Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents. 105
Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors 103
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 98
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents 95
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights 94
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies 94
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity 93
Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms 91
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors 88
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition 85
Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris 82
Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae 80
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation 76
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells 74
Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs–a joint docking/molecular dynamics study 73
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation 73
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors 72
Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin 71
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies 70
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis 70
Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors 70
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII 68
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop 65
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII 63
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors 62
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies 61
Selective inhibition of helicobacter pylori carbonic anhydrases by carvacrol and thymol could impair biofilm production and the release of outer membrane vesicles 59
Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction 55
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation 55
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors 55
A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors 53
4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors 53
Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis 53
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments 51
Synthetic Approaches to Novel Human Carbonic Anhydrase Isoform Inhibitors Based on Pyrrol-2-one Moiety 49
Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors 49
Treatment of glaucoma and ocular hypertension using rho kinase inhibitors: patent evaluation of US2018244666 and US2018256595 48
Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains 48
Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis 47
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography 46
4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors 45
6-Aminocoumarin oxime-ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies 44
Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols 44
Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides 44
Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors 44
Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors 42
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents 42
Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide-hydantoin hybrids 41
Inhibition Profiles of Some Novel Sulfonamide-Incorporated α-Aminophosphonates on Human Carbonic Anhydrases 41
Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris 40
Sulfonamide-incorporated bis(α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies 39
Exploration of 3-aryl pyrazole-tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors 39
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights 39
Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N-((4-Sulfamoylphenyl)carbamothioyl) Amides 38
Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors 35
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors 34
Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases 24
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Totale 4.856
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Categoria #
all - tutte 17.627
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 17.627
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020175 0 0 0 0 0 0 35 39 34 18 44 5
2020/2021314 21 18 18 20 28 51 7 22 43 48 20 18
2021/2022287 1 2 18 32 7 12 16 30 53 26 30 60
2022/2023689 62 156 56 16 34 92 88 23 62 65 23 12
2023/2024437 3 41 60 23 35 44 27 65 12 70 38 19
2024/20252.702 89 351 247 412 917 644 42 0 0 0 0 0
Totale 4.856