BONARDI, ALESSANDRO
 Distribuzione geografica
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Continente #
NA - Nord America 4.622
AS - Asia 3.154
EU - Europa 2.714
SA - Sud America 566
Continente sconosciuto - Info sul continente non disponibili 151
AF - Africa 118
OC - Oceania 31
Totale 11.356
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Nazione #
US - Stati Uniti d'America 4.484
RU - Federazione Russa 1.061
CN - Cina 882
IT - Italia 838
SG - Singapore 835
BR - Brasile 443
HK - Hong Kong 377
VN - Vietnam 315
KR - Corea 274
PL - Polonia 162
IE - Irlanda 158
IN - India 132
FR - Francia 116
SE - Svezia 98
BD - Bangladesh 95
CA - Canada 92
FI - Finlandia 72
DE - Germania 59
GB - Regno Unito 49
JP - Giappone 46
AR - Argentina 45
ID - Indonesia 42
EG - Egitto 36
JO - Giordania 29
AU - Australia 27
PK - Pakistan 27
NL - Olanda 25
EC - Ecuador 23
IQ - Iraq 23
CO - Colombia 22
UA - Ucraina 20
NG - Nigeria 19
TR - Turchia 15
MX - Messico 14
ES - Italia 13
ZA - Sudafrica 13
MA - Marocco 12
CI - Costa d'Avorio 11
TN - Tunisia 11
VE - Venezuela 10
SA - Arabia Saudita 9
HN - Honduras 8
MY - Malesia 8
AE - Emirati Arabi Uniti 7
AL - Albania 7
PE - Perù 7
PY - Paraguay 7
CR - Costa Rica 6
CZ - Repubblica Ceca 6
KE - Kenya 6
CH - Svizzera 5
GT - Guatemala 5
JM - Giamaica 5
TW - Taiwan 5
UZ - Uzbekistan 5
BJ - Benin 4
NZ - Nuova Zelanda 4
PH - Filippine 4
AZ - Azerbaigian 3
BE - Belgio 3
CL - Cile 3
IL - Israele 3
LT - Lituania 3
NO - Norvegia 3
RO - Romania 3
UY - Uruguay 3
BB - Barbados 2
BG - Bulgaria 2
BO - Bolivia 2
CG - Congo 2
DZ - Algeria 2
IR - Iran 2
KG - Kirghizistan 2
LB - Libano 2
NP - Nepal 2
OM - Oman 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
SY - Repubblica araba siriana 2
AM - Armenia 1
AT - Austria 1
BH - Bahrain 1
BS - Bahamas 1
CY - Cipro 1
DK - Danimarca 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GR - Grecia 1
HR - Croazia 1
HU - Ungheria 1
LK - Sri Lanka 1
MD - Moldavia 1
MQ - Martinica 1
MT - Malta 1
PA - Panama 1
PT - Portogallo 1
RS - Serbia 1
SC - Seychelles 1
SR - Suriname 1
Totale 11.204
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Città #
Santa Clara 1.260
Ashburn 679
Singapore 640
Hong Kong 319
Hefei 297
Seoul 267
San Jose 245
Fairfield 184
Warsaw 158
Council Bluffs 156
Dublin 155
Beijing 131
Milan 129
Los Angeles 117
Ho Chi Minh City 111
Chandler 107
Florence 98
Rome 85
The Dalles 80
Houston 73
Seattle 72
Moscow 71
Lauterbourg 68
Woodbridge 68
Hanoi 66
Mumbai 63
Dallas 60
Lawrence 59
Cambridge 56
Altamura 54
Phoenix 53
Wilmington 51
Buffalo 46
Helsinki 43
Kent 43
New York 39
Tokyo 36
Boston 34
São Paulo 34
Princeton 33
Jakarta 26
Lappeenranta 25
Melbourne 24
Toronto 22
Figino 21
London 21
Naples 20
Ann Arbor 19
Bengaluru 19
Paris 19
Saint-Laurent-du-Var 18
Abuja 17
Frankfurt am Main 17
Giza 17
Turin 17
Chicago 16
Montreal 16
Shanghai 16
Boardman 15
Haiphong 15
Munich 15
Brasília 13
Lahore 12
Rio de Janeiro 12
Washington 12
Abidjan 11
Sesto Fiorentino 11
West Jordan 11
Yubileyny 11
Biên Hòa 10
Charlotte 10
Da Nang 10
Medford 10
Orem 10
San Diego 10
Stockholm 10
Clifton 9
Miano 9
Bologna 8
Philadelphia 8
San Francisco 8
Amsterdam 7
Atlanta 7
Baghdad 7
Belo Horizonte 7
Cagliari 7
Cairo 7
Chandigarh 7
Delhi 7
Dong Ket 7
Hải Dương 7
Newark 7
Palermo 7
Quito 7
Amman 6
Bari 6
Bogotá 6
Chaoyang 6
Chennai 6
Cleveland 6
Totale 7.067
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Nome #
In silico strategies for the rational design, synthesis, and biological evaluation of ligands targeting macromolecules of pharmaceutical interest 298
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 294
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform 261
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 238
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 237
Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction 232
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors 226
Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights 219
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction 212
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats 210
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies 208
Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents. 190
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action 183
Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases 174
A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors 173
4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors 170
N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis 170
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights 169
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies 164
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop 161
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography 159
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition 158
Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors 156
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation 154
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII 150
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents 146
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors 145
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors 144
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments 140
Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae 139
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation 139
Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors 138
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity 138
Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis 136
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis 136
Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms 136
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells 136
Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris 134
6-Aminocoumarin oxime-ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies 133
Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors 132
4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors 131
Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris 130
Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs–a joint docking/molecular dynamics study 130
Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides 128
Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols 127
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies 126
Synthetic Approaches to Novel Human Carbonic Anhydrase Isoform Inhibitors Based on Pyrrol-2-one Moiety 125
Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin 125
Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors 123
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII 123
Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide-hydantoin hybrids 122
Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains 121
Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators 120
Exploration of 3-aryl pyrazole-tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors 119
Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity 116
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors 114
Sulfonamide-incorporated bis(α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies 113
Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis 113
Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition 112
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents 112
Selective inhibition of helicobacter pylori carbonic anhydrases by carvacrol and thymol could impair biofilm production and the release of outer membrane vesicles 111
Treatment of glaucoma and ocular hypertension using rho kinase inhibitors: patent evaluation of US2018244666 and US2018256595 109
Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors 109
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights 109
Exploring the Polypharmacological Potential of PCI-27483: A Selective Inhibitor of Carbonic Anhydrases IX and XII 105
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors 105
Inhibition Profiles of Some Novel Sulfonamide-Incorporated α-Aminophosphonates on Human Carbonic Anhydrases 103
Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N-((4-Sulfamoylphenyl)carbamothioyl) Amides 99
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation 98
Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors 95
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors 78
Exploration of New Pyrazole–Hydrazone–Benzenesulfonamide Conjugates as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation 63
Exploring aliphatic sulfonamides as multiclass inhibitors of the carbonic anhydrases from the pathogen bacterium Vibrio cholerae 57
Design and synthesis of isoxazole-functionalized benzene sulphonamides as novel inhibitors of Mycobacterium tuberculosis β-carbonic anhydrases 52
Production, crystallographic studies, and functional profiling of γ-carbonic anhydrase from the probiotic Limosilactobacillus reuteri: In vitro and cell-based insights 52
Benzoxaboroles Are Inhibitors of the η-Class Carbonic Anhydrase From Plasmodium falciparum 51
Novel 3-Sulfonamide Dual-Tail Pyrrol-2-one Bridged Molecules as Potent Human Carbonic Anhydrase Isoform Inhibitors: Design, Synthesis, Molecular Modeling Investigation, and Anticancer Activity in MeWo, SK-BR-3, and MG-63 Cell Lines 48
Studies on Azasugar-based sulfonamides: a new class of Carbonic Anhydrase inhibitors 44
Sulfonamide-arylidene hybrids featuring flexible hydrazide and rigid triazole linkers: design, synthesis, and evaluation as carbonic anhydrase inhibitors with anti-breast cancer potential 43
Exploring Indole-Linked Triazole Sulfonamide Derivatives as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Leveraging a Tail Approach for the Design, Synthesis, and In Silico Studies─An In-Depth Multidisciplinary Study 39
Dual-Targeting Anticancer Agents: Design and Evaluation of Compounds Targeting Carbonic Anhydrase and Histone Deacetylase 34
Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors 34
Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases 34
Investigation on N-Aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamide as Human Carbonic Anhydrases Inhibitors 30
Redesigning oxazolidinones as carbonic anhydrase inhibitors against vancomycin-resistant enterococci 29
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II 27
Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases 24
Sideroxylonal B: A Dimeric Phloroglucinol From Eucalyptus cinerea With In Vitro Carbonic Anhydrase Inhibition and Evaluation of Cytotoxicity and Antiviral Potential 22
Computational Approaches and Structure-Based Drug Design of CAIs 21
Polypharmacology of carbonic anhydrase inhibitors and activators 17
New 7‐hydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies 12
Computational approaches for designing viral protease inhibitors 9
Structural and Pharmacological Characterization of AT-121 Reveals Carbonic Anhydrase Inhibition as a Complementary Mechanism to Dual MOR/NOR Agonism 8
Rational design and synthesis of pyrazole-based sulfonamides as dual carbonic anhydrase and PRAK-targeting anticancer agents 7
Multi-faceted exploration of the novel active γ-carbonic anhydrase PaCAγ1 in the human pathogen Pseudomonas aeruginosa 7
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Totale 11.356
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Categoria #
all - tutte 35.337
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.337
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022284 0 0 18 32 7 12 16 30 53 26 30 60
2022/2023689 62 156 56 16 34 92 88 23 62 65 23 12
2023/2024437 3 41 60 23 35 44 27 65 12 70 38 19
2024/20253.456 89 351 247 412 917 644 115 102 132 92 169 186
2025/20265.035 437 655 659 551 390 154 459 295 328 281 283 543
2026/2027711 265 171 275 0 0 0 0 0 0 0 0 0
Totale 11.356