BONARDI, ALESSANDRO
 Distribuzione geografica
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Continente #
NA - Nord America 4.233
AS - Asia 3.257
EU - Europa 2.703
SA - Sud America 560
AF - Africa 138
OC - Oceania 40
Continente sconosciuto - Info sul continente non disponibili 1
Totale 10.932
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Nazione #
US - Stati Uniti d'America 4.146
RU - Federazione Russa 1.072
CN - Cina 912
SG - Singapore 849
IT - Italia 815
BR - Brasile 438
HK - Hong Kong 379
VN - Vietnam 318
KR - Corea 284
PL - Polonia 162
IE - Irlanda 157
IN - India 154
FR - Francia 102
BD - Bangladesh 101
SE - Svezia 97
FI - Finlandia 72
DE - Germania 60
GB - Regno Unito 58
CA - Canada 56
JP - Giappone 53
AR - Argentina 45
EG - Egitto 43
ID - Indonesia 42
AU - Australia 36
PK - Pakistan 34
NL - Olanda 31
JO - Giordania 30
IQ - Iraq 22
EC - Ecuador 21
UA - Ucraina 20
NG - Nigeria 18
TR - Turchia 17
ZA - Sudafrica 17
CO - Colombia 16
PE - Perù 16
ES - Italia 13
MA - Marocco 12
CI - Costa d'Avorio 11
DZ - Algeria 11
MX - Messico 11
TN - Tunisia 11
TW - Taiwan 11
VE - Venezuela 9
SA - Arabia Saudita 8
AE - Emirati Arabi Uniti 7
PY - Paraguay 7
AL - Albania 6
CZ - Repubblica Ceca 6
CH - Svizzera 5
KE - Kenya 5
LT - Lituania 5
UZ - Uzbekistan 5
BE - Belgio 4
BJ - Benin 4
CR - Costa Rica 4
DK - Danimarca 4
JM - Giamaica 4
MY - Malesia 4
NZ - Nuova Zelanda 4
PH - Filippine 4
AZ - Azerbaigian 3
CL - Cile 3
GT - Guatemala 3
HN - Honduras 3
IL - Israele 3
UY - Uruguay 3
BB - Barbados 2
BG - Bulgaria 2
BO - Bolivia 2
HU - Ungheria 2
IR - Iran 2
KG - Kirghizistan 2
LB - Libano 2
NP - Nepal 2
OM - Oman 2
SK - Slovacchia (Repubblica Slovacca) 2
ZM - Zambia 2
AM - Armenia 1
AT - Austria 1
BH - Bahrain 1
BS - Bahamas 1
CG - Congo 1
CY - Cipro 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
GR - Grecia 1
HR - Croazia 1
LK - Sri Lanka 1
MD - Moldavia 1
MT - Malta 1
PA - Panama 1
PT - Portogallo 1
RO - Romania 1
RS - Serbia 1
SC - Seychelles 1
SV - El Salvador 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
Totale 10.931
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Città #
Santa Clara 1.251
Ashburn 665
Singapore 654
Hong Kong 324
Hefei 310
Seoul 275
Fairfield 184
San Jose 162
Warsaw 158
Dublin 155
Beijing 136
Milan 122
Council Bluffs 116
Ho Chi Minh City 110
Los Angeles 108
Chandler 107
Florence 101
Rome 81
Seattle 72
The Dalles 72
Houston 71
Moscow 71
Hanoi 69
Lauterbourg 68
Woodbridge 68
Mumbai 65
Lawrence 59
Dallas 58
Cambridge 56
Altamura 54
Wilmington 51
Buffalo 48
Kent 44
Helsinki 43
New York 43
Tokyo 37
Boston 34
Princeton 33
São Paulo 33
Jakarta 26
Melbourne 26
Lappeenranta 25
Bengaluru 20
Giza 20
London 20
Phoenix 20
Ann Arbor 19
Paris 19
Abuja 18
Frankfurt am Main 18
Naples 18
Shanghai 17
Turin 17
Haiphong 15
Munich 15
Toronto 15
Boardman 14
Chicago 14
Lahore 13
Lima 13
Rio de Janeiro 12
Abidjan 11
Montreal 11
San Diego 11
Sesto Fiorentino 11
Washington 11
West Jordan 11
Yubileyny 11
Biên Hòa 10
Charlotte 10
Da Nang 10
Figino 10
Medford 10
Miano 10
Orem 10
Brasília 9
Cairo 9
Clifton 9
Stockholm 9
Bologna 8
Chennai 8
Genoa 8
Hải Dương 8
Amman 7
Amsterdam 7
Belo Horizonte 7
Brescia 7
Cagliari 7
Chandigarh 7
Delhi 7
Dong Ket 7
Johannesburg 7
New Delhi 7
Quito 7
San Francisco 7
Sydney 7
Atlanta 6
Baghdad 6
Bari 6
Cape Town 6
Totale 6.892
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Nome #
Computational approaches in drug discovery: strategies to address polypharmacology and the synthesis/optimization of lead compounds 373
In silico strategies for the rational design, synthesis, and biological evaluation of ligands targeting macromolecules of pharmaceutical interest 289
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 278
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform 258
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 226
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 224
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors 222
Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights 212
Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction 200
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction 200
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats 197
Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents. 185
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action 179
A Series of Thiadiazolyl-Benzenesulfonamides Incorporating an Aromatic Tail as Isoform-Selective, Potent Carbonic Anhydrase II/XII Inhibitors 168
N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis 167
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies 166
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights 166
Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases 164
4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors 164
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies 162
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop 156
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition 155
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography 152
Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors 151
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation 149
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII 148
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents 143
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors 141
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors 140
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity 134
Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae 134
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells 134
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation 133
Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris 132
Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors 132
Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis 131
6-Aminocoumarin oxime-ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies 130
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments 130
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis 129
Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms 129
Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors 128
4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors 126
Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris 125
Pharmaceutical strategies for preventing toxicity and promoting antioxidant and anti-inflammatory actions of bilirubin 124
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies 123
Synthetic Approaches to Novel Human Carbonic Anhydrase Isoform Inhibitors Based on Pyrrol-2-one Moiety 122
Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols 122
Inhibition of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with aromatic sulphonamides and clinically licenced drugs–a joint docking/molecular dynamics study 122
Diversely N-substituted benzenesulfonamides dissimilarly bind to human carbonic anhydrases: crystallographic investigations of N-nitrosulfonamides 122
Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide-hydantoin hybrids 119
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII 118
Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors 116
Exploration of 3-aryl pyrazole-tethered sulfamoyl carboxamides as carbonic anhydrase inhibitors 115
Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant Mycobacterium tuberculosis Strains 113
Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity 112
Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators 112
Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis 111
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors 110
Sulfonamide-incorporated bis(α-aminophosphonates) as promising carbonic anhydrase inhibitors: Design, synthesis, biological evaluation, and X-ray crystallographic studies 109
Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents 108
Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors 107
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights 107
Treatment of glaucoma and ocular hypertension using rho kinase inhibitors: patent evaluation of US2018244666 and US2018256595 104
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors 102
Exploring the Polypharmacological Potential of PCI-27483: A Selective Inhibitor of Carbonic Anhydrases IX and XII 101
Inhibition Profiles of Some Novel Sulfonamide-Incorporated α-Aminophosphonates on Human Carbonic Anhydrases 101
Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition 101
Selective inhibition of helicobacter pylori carbonic anhydrases by carvacrol and thymol could impair biofilm production and the release of outer membrane vesicles 101
Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N-((4-Sulfamoylphenyl)carbamothioyl) Amides 97
Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation 96
Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors 92
Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors 75
Exploration of New Pyrazole–Hydrazone–Benzenesulfonamide Conjugates as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Design, Synthesis, and Biological Evaluation 54
Benzoxaboroles Are Inhibitors of the η-Class Carbonic Anhydrase From Plasmodium falciparum 50
Exploring aliphatic sulfonamides as multiclass inhibitors of the carbonic anhydrases from the pathogen bacterium Vibrio cholerae 44
Production, crystallographic studies, and functional profiling of γ-carbonic anhydrase from the probiotic Limosilactobacillus reuteri: In vitro and cell-based insights 41
Studies on Azasugar-based sulfonamides: a new class of Carbonic Anhydrase inhibitors 38
Design and synthesis of isoxazole-functionalized benzene sulphonamides as novel inhibitors of Mycobacterium tuberculosis β-carbonic anhydrases 37
Novel 3-Sulfonamide Dual-Tail Pyrrol-2-one Bridged Molecules as Potent Human Carbonic Anhydrase Isoform Inhibitors: Design, Synthesis, Molecular Modeling Investigation, and Anticancer Activity in MeWo, SK-BR-3, and MG-63 Cell Lines 37
Investigation on N-Aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamide as Human Carbonic Anhydrases Inhibitors 29
Sulfonamide-arylidene hybrids featuring flexible hydrazide and rigid triazole linkers: design, synthesis, and evaluation as carbonic anhydrase inhibitors with anti-breast cancer potential 28
Exploring Indole-Linked Triazole Sulfonamide Derivatives as Potent Mycobacterial Carbonic Anhydrase Inhibitors: Leveraging a Tail Approach for the Design, Synthesis, and In Silico Studies─An In-Depth Multidisciplinary Study 25
Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors 24
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II 22
Redesigning oxazolidinones as carbonic anhydrase inhibitors against vancomycin-resistant enterococci 21
Dual-Targeting Anticancer Agents: Design and Evaluation of Compounds Targeting Carbonic Anhydrase and Histone Deacetylase 20
Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases 16
Sideroxylonal B: A Dimeric Phloroglucinol From Eucalyptus cinerea With In Vitro Carbonic Anhydrase Inhibition and Evaluation of Cytotoxicity and Antiviral Potential 15
Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases 15
Computational Approaches and Structure-Based Drug Design of CAIs 13
Polypharmacology of carbonic anhydrase inhibitors and activators 7
Multi-faceted exploration of the novel active γ-carbonic anhydrase PaCAγ1 in the human pathogen Pseudomonas aeruginosa 5
Computational approaches for designing viral protease inhibitors 4
Rational design and synthesis of pyrazole-based sulfonamides as dual carbonic anhydrase and PRAK-targeting anticancer agents 4
Structural and Pharmacological Characterization of AT-121 Reveals Carbonic Anhydrase Inhibition as a Complementary Mechanism to Dual MOR/NOR Agonism 4
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New 7‐hydroxycoumarin acetamide derivatives as human carbonic anhydrase IX and XII inhibitors: Design, synthesis, biological evaluation and molecular docking studies 3
Totale 11.083
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Categoria #
all - tutte 32.973
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 32.973
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022287 1 2 18 32 7 12 16 30 53 26 30 60
2022/2023689 62 156 56 16 34 92 88 23 62 65 23 12
2023/2024437 3 41 60 23 35 44 27 65 12 70 38 19
2024/20253.641 89 351 247 412 917 644 115 102 226 140 192 206
2025/20265.222 455 676 686 560 393 160 471 304 333 288 326 570
2026/202766 66 0 0 0 0 0 0 0 0 0 0 0
Totale 11.083