Zinc(II) ion participates directly in the catalytic process of the carbonic anhydrase (CA; EC 4.2.1.1) enzymes exhibiting a distorted tetrahedral geometry with three ligands bound to the zinc ion and the fourth ligand being a water molecule that is an activated nucleophile for the catalytic process. A coordination number of five can also be encountered for Zn(II) ions, with a trigonal bipyramidal geometry of the metal center. In this chapter the most common coordination features of selected inhibitors of the CAs acting as Zn(II) binders are discussed.
Mechanisms of action of carbonic anhydrase inhibitors: Zinc binders / Vullo D.; Carta F.. - ELETTRONICO. - (2019), pp. 187-222. [10.1016/B978-0-12-816476-1.00009-5]
Mechanisms of action of carbonic anhydrase inhibitors: Zinc binders
Vullo D.;Carta F.
2019
Abstract
Zinc(II) ion participates directly in the catalytic process of the carbonic anhydrase (CA; EC 4.2.1.1) enzymes exhibiting a distorted tetrahedral geometry with three ligands bound to the zinc ion and the fourth ligand being a water molecule that is an activated nucleophile for the catalytic process. A coordination number of five can also be encountered for Zn(II) ions, with a trigonal bipyramidal geometry of the metal center. In this chapter the most common coordination features of selected inhibitors of the CAs acting as Zn(II) binders are discussed.
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