CASCELLA, ROBERTA
 Distribuzione geografica
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Continente #
EU - Europa 4.854
NA - Nord America 4.049
AS - Asia 741
OC - Oceania 40
AF - Africa 13
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 9.702
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Nazione #
US - Stati Uniti d'America 4.026
PL - Polonia 2.781
RU - Federazione Russa 926
IT - Italia 399
IE - Irlanda 264
SE - Svezia 206
HK - Hong Kong 170
SG - Singapore 164
CN - Cina 136
IN - India 90
FI - Finlandia 65
DE - Germania 61
VN - Vietnam 61
ID - Indonesia 51
GB - Regno Unito 43
AU - Australia 35
JO - Giordania 33
CH - Svizzera 26
CA - Canada 22
ES - Italia 18
NL - Olanda 17
BE - Belgio 14
TR - Turchia 10
CI - Costa d'Avorio 9
FR - Francia 9
KR - Corea 8
UA - Ucraina 8
RO - Romania 6
JP - Giappone 5
NZ - Nuova Zelanda 5
AT - Austria 4
BD - Bangladesh 3
BR - Brasile 2
CZ - Repubblica Ceca 2
EG - Egitto 2
IL - Israele 2
IR - Iran 2
LU - Lussemburgo 2
PK - Pakistan 2
TW - Taiwan 2
AE - Emirati Arabi Uniti 1
CO - Colombia 1
DK - Danimarca 1
EC - Ecuador 1
EU - Europa 1
GR - Grecia 1
LT - Lituania 1
MA - Marocco 1
MU - Mauritius 1
MX - Messico 1
PH - Filippine 1
Totale 9.702
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Città #
Warsaw 2.780
Santa Clara 1.234
Fairfield 403
Chandler 279
Dublin 263
Ashburn 240
Woodbridge 180
Houston 175
Seattle 162
Cambridge 156
Wilmington 146
Singapore 136
Hong Kong 120
Florence 119
Ann Arbor 100
Altamura 91
Lawrence 86
Princeton 69
Dong Ket 57
Boston 55
Beijing 51
Jakarta 50
Moscow 47
Mumbai 41
Bremen 38
Melbourne 33
Pune 32
Boardman 31
Shanghai 30
San Diego 29
Bern 22
Dearborn 21
Phoenix 19
Kent 18
Lappeenranta 18
Milan 18
Medford 17
Barcelona 16
Helsinki 15
New York 12
Brussels 10
Los Angeles 10
Oakland 10
Rohtak 10
Rome 10
Abidjan 9
Jacksonville 9
Redwood City 9
Montreal 8
Norwalk 8
London 7
Amsterdam 6
Andover 6
Izmir 6
Peterborough 5
Yubileyny 5
Central 4
Falls Church 4
Grenoble 4
Hillsboro 4
Liège 4
Naples 4
Poggio a Caiano 4
Sant'oreste 4
Serra 4
Swampscott 4
Verona 4
Vienna 4
Bucharest 3
Buffalo 3
Dallas 3
Hamilton 3
Hwaseong-si 3
Livorno 3
San Jose 3
Santa Maria A Monte 3
Seoul 3
Turin 3
Woking 3
Bella 2
Cairo 2
Caserta 2
Castelliri 2
Catania 2
Chicago 2
Detroit 2
Durham 2
Falkenstein 2
Fribourg 2
Garching 2
Genova 2
Grellingen 2
Groningen 2
Guangzhou 2
Handan 2
Hefei 2
Islamabad 2
Jacou 2
Kensington 2
Kunming 2
Totale 7.660
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Nome #
Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: A mechanistic insight 286
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells 262
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia 259
Quantification of the Relative Contributions of Loss-of function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies 254
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases 253
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity 249
Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload 249
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells 245
Effect of molecular chaperones on aberrant protein oligomers in vitro: super- versus sub-stoichiometric chaperone concentrations 245
TDP-43 inclusion bodies formed in bacteria are structurally amorphous, non-amyloid and inherently toxic to neuroblastoma cells 244
Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy 242
Lipid Rafts Mediate Amyloid-induced Calcium Dyshomeostasis and Oxidative Stress in Alzheimer's Disease. 241
Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers 233
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions 232
Glutathione intake promotes longevity through the activation of SIR-2.1 and DAF-16 (FoxO) pathway in C. elegans 209
Selenium and zinc: Two key players against cadmium-induced neuronal toxicity. 209
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers 201
α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies 196
The acute myeloid leukemia-associated nucleophosmin 1 gene mutations dictate amyloidogenicity of the C-terminal domain 196
Single particle tracking to study the binding of protein misfolded oligomer to membrane ganglioside GM1 193
Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases 190
Molecular links between aberrant protein oligomers and neurodegeneration in Alzheimer’s disease 189
The toxicity of misfolded protein oligomers is independent of their secondary structure 182
Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine 175
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes 167
Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane 164
S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans 162
Nanoscopic insights into the surface conformation of neurotoxic amyloid b oligomers 144
Targeting pathological amyloid aggregates with conformation-sensitive antibodies 141
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers 138
Probing the origin of the toxicity of oligomeric aggregates of α-synuclein with antibodies 138
Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View 135
A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells 129
Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity. 126
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro 126
Allele specific Taqman–based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients. 124
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains 124
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers 123
Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models. Free Radic Biol Med. 122
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism 122
Plasma Membrane Injury Depends on Bilayer Lipid Composition in Alzheimer’s Disease 118
Light-responsive nanocomposite sponges for on demand chemical release with high spatial and dosage control 116
Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy 111
Squalamine and its derivatives modulate the aggregation of amyloid-β and α-synuclein and suppress the toxicity of their oligomers 97
Amyloid cytotoxicity depends on membrane lipid composition in Alzheimer's disease 93
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells 93
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity 93
Chaperones suppress protein oligomer toxicity: Insight into the molecular mechanism of action 88
Aβ oligomers dysregulate calcium homeostasis by mechanosensitive activation of AMPA and NMDA receptors. 87
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress 83
Chaperones suppress the toxicity of aberrant protein aggregates. Molecular insight into the mechanism of action 78
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases 76
Exploring the release of toxic oligomers from α-synuclein fibrils with antibodies and sted microscopy 75
Sphingosine 1-phosphate attenuates neuronal dysfunction induced by amyloid-β oligomers through endocytic internalization of NMDA receptors 74
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature 70
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species 69
Calcium dyshomeostasis in Alzheimer’s disease pathogenesis 68
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies 68
APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility 67
A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43 66
Oxidative Stress and Mitochondrial Damage in Neurodegenerative Diseases: From Molecular Mechanisms to Targeted Therapies 65
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers 65
Exploring the Aβ1-42 fibrillogenesis timeline by atomic force microscopy and surface enhanced Raman spectroscopy 57
Putative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort 56
The Toxicity of Protein Aggregates: New Insights into the Mechanisms 56
Structure-toxicity relationship in intermediate fibrils from lα-Synuclein condensates 54
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes 51
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF 45
An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature 44
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases 30
Totale 9.832
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Categoria #
all - tutte 24.422
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.422
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020785 0 0 0 0 0 0 160 199 141 109 149 27
2020/20211.191 90 150 15 162 99 118 74 73 105 177 49 79
2021/2022446 35 43 53 14 13 18 15 31 26 37 42 119
2022/20231.365 106 254 73 130 89 216 161 74 129 42 50 41
2023/2024620 28 61 60 26 35 128 33 125 13 44 32 35
2024/20252.776 101 366 204 523 1.100 464 18 0 0 0 0 0
Totale 9.832