GIOVANNONI, MARIA PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 5.618
EU - Europa 5.250
AS - Asia 786
AF - Africa 33
SA - Sud America 11
Continente sconosciuto - Info sul continente non disponibili 1
Totale 11.699
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Nazione #
US - Stati Uniti d'America 5.608
PL - Polonia 2.148
RU - Federazione Russa 1.296
SE - Svezia 396
IE - Irlanda 392
IT - Italia 365
SG - Singapore 268
HK - Hong Kong 199
UA - Ucraina 185
GB - Regno Unito 153
DE - Germania 144
CN - Cina 138
FI - Finlandia 93
IN - India 75
VN - Vietnam 41
JO - Giordania 38
BE - Belgio 23
CI - Costa d'Avorio 22
FR - Francia 19
TR - Turchia 19
ES - Italia 13
CA - Canada 10
NL - Olanda 10
SC - Seychelles 8
CH - Svizzera 7
BR - Brasile 6
CO - Colombia 5
RO - Romania 3
EG - Egitto 2
IR - Iran 2
JP - Giappone 2
BY - Bielorussia 1
CZ - Repubblica Ceca 1
EU - Europa 1
KR - Corea 1
KZ - Kazakistan 1
MU - Mauritius 1
RS - Serbia 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 11.699
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Città #
Warsaw 2.147
Santa Clara 999
Fairfield 648
Chandler 455
Dublin 391
Ashburn 352
Seattle 314
Jacksonville 276
Woodbridge 261
Cambridge 256
Houston 224
Singapore 210
Wilmington 194
Ann Arbor 155
Florence 119
Hong Kong 113
Princeton 108
Altamura 106
Lawrence 101
Buffalo 91
Mumbai 66
Boardman 65
Medford 61
Boston 55
Moscow 50
Shanghai 46
San Diego 40
Beijing 34
Dong Ket 33
New York 28
West Jordan 25
Abidjan 22
Brussels 22
London 21
Philadelphia 20
Izmir 16
Norwalk 16
Hillsboro 15
Los Angeles 15
Phoenix 14
Barcelona 13
Frankfurt Am Main 13
Helsinki 13
Yubileyny 13
Kent 12
Verona 11
Milan 10
Falls Church 8
Toronto 8
Bern 7
Gavirate 6
Lappeenranta 6
Andover 5
Bogotá 5
Fuzhou 5
Menlo Park 5
Pune 5
Tappahannock 5
Teresópolis 5
Fort Worth 4
Guangzhou 4
Laurel 4
Misano Adriatico 4
Munich 4
Napoli 4
Redmond 4
Rome 4
Shenzhen 4
Auburn Hills 3
Esslingen am Neckar 3
Leawood 3
Salerno 3
Scandicci 3
Southwark 3
Zhengzhou 3
Amsterdam 2
Campo San Martino 2
Carol Stream 2
Castelliri 2
Chennai 2
Chicago 2
Crawley 2
Dearborn 2
Dortmund 2
Nürnberg 2
Paris 2
Prescot 2
Redwood City 2
Romola 2
Rui'an 2
Secaucus 2
Timisoara 2
Trumbull 2
Washington 2
Whitechapel 2
Antwerpen 1
Atlanta 1
Augusta 1
Beograd 1
Bologna 1
Totale 8.441
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Nome #
Synthesis, HPLC enantioresolution and X-ray analysis of a new series of C5-methyl pyridazines as N-formyl peptide receptor (FPR) agonists 274
[(3-chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents 261
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists. 239
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 233
Synthesis and pharmacological evaluation of new pyridazin-based thioderivatives as formyl peptide receptor (FPR) agonists 230
Synthesis and evaluation as antitubercular agents of 5-arylethenyl and 5-(hetero)aryl-3-isoxazolecarboxylate 225
Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives 223
Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition 221
α2 Adrenoceptor: a Target for Neuropathic Pain Treatment 221
Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase 215
Isoxazolo-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors 212
Synthesis, enantioresolution and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. 209
Synthesis and pharmacological evaluation of novel GABAA subtype receptor ligands with potential anxiolytic-like and anti-hyperlagesic effect 191
New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4-(3H)-ones fluoroderivatives as human A1 adenosine receptor ligands 190
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase 185
2-Arylacetamido-4-phenylamino-5-substituted pyridazinones as formyl peptide receptors agonists. 171
Synthesis and pharmacological evaluation of indole derivatives as deaza analogues of potent human neutrophil elastase inhibitors 160
Synthesis of five and six-membered N-phenylacetamido substituted heterocycles as formyl peptide receptor agonists 155
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists. 150
Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors 144
Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors 143
Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold 140
Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors 136
1H-pyrrolo[2,3-b]pyridine: a new scaffold for human neutrophil elastase (HNE) inhibitors 133
Cinnoline derivatives as human neutrophil elastase inhibitors 132
Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis. 129
4-SUBSTITUTED-5-ACETYL-2-METHYL-6-PHENYL-3(2H)PYRIDAZINONES AS PGE2 AND IL-1 RELEASE INHIBITORS FROM MOUSE ADHERENT MACROPHAGES 126
A combined crystallographic and computational study on dexketoprofen trometamol dihydrate salt 124
Synthesis of five and six-membered heterocycles bearing an arylpiperazinylalkyl side chain as orally active antinociceptive agents 124
4-AMINO-3(2H)-PYRIDAZINONES BEARING ARYLPIPERAZINYLALKYL GROUPS AND RELATED COMPOUNDS: SYNTHESIS AND ANTINOCICEPTIVE ACTIVITY 121
4-Amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action 120
Diels-Alder Reactions on 5-Acetyl-2-methyl-4-nitro-6-phenylpyridazin-3(2H)-one: a New Facet of the Pyridazine System 118
New pyrazolo[1',5':1,6]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors 118
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action 118
ANTINOCICEPTIVE ACTIVITY OF A 3(2H)-PYRIDAZINONE DERIVATE IN MICE 117
Identification of a new pyrazolo[1,5-a]quinazoline ligand highly affine to γ-aminobutyric type A (GABAA) receptor subtype with anxiolytic-like and antihyperalgesic activity 116
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 115
Further modifications of 1H-pyrrolo[2,3-b]pyridine derivatives as inhibitors of human neutrophil elastase 115
CHIRAL RESOLUTION AND ABSOLUTE CONFIGURATION OF THE ENANTIOMERS OF 5-ACETYL-2-METHYL-4-METHYLSULFINYL-6-PHENYL-3(2H)-PYRIDAZINONE AND EVALUATION OF THEIR PLATELET AGGREGATION INHIBITORY ACTIVITY 114
5-ACETYL-2-METHYL-4-NITRO-6-PHENYL-3(2H)-PYRIDAZINONE:VERSATILE PRECURSOR TO HETERO-CONDENSED PYRIDAZINONES 113
PHOSPHODIESTERASE 4 INHIBITORS, STRUCTURALLY UNRELATED TO ROLIPRAM, AS PROMISING AGENTS FOR THE TREATMENT OF ASTHMA AND OTHER PATHOLOGIES 112
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: synthesis and evaluation of their phosphodiesterase 4 inhibitory activity 112
MONO- AND DI-SUBSTITUTED 5,6-DIPHENYL-3-ALKYLAMINO-PYRIDAZINES ACTIVE AS ACAT INHIBITORS 112
ISOXAZOLO[3,4-D]PYRIDAZINONES AND ANALOGUES AS LEISHMANIA MEXICANA PDE INHIBITORS 109
4-amino-5-vinyl-3(2H)-pyridazinones and analogues as potent antinociceptive agents: synthesis, SARs, and preliminary studies on the mechanism of action 109
6-Methyl-2,4-disubstituted pyridazin-3(2H)-ones: a novel class of small-molecule agonists for formyl peptide receptors. 108
SELECTIVE ACAT INHIBITORS AS PROMISING ANTIHYPERLIPIDEMIC, ANTIATHEROSCLEROTIC AND ANTI-ALZHEIMER DRUGS 107
AIRWAY RELAXANT AND ANTI-INFLAMMATORY PROPERTIES OF A PDE 4 INHIBITOR WITH LOW AFFINITY FOR THE HIGH-AFFINITY ROLIPRAM BINDING SITE 105
5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and related 4-amino compounds: synthesis and pharmacological evaluation 105
ISOXAZOLO[3,4-D]PYRIDAZIN-7-(6H)-ONE AS A POTENTIAL SUBSTRATE FOR NEW ALDOSE REDUCTASE INHIBITORS 103
New 3-unsubstituted Isoxazolones as Potent Human Neutrophil Elastase Inhibitors: Synthesis and Molecular Dynamic Simulation 102
NOVEL HETEROCYCLIC-FUSED PYRIDAZINONES AS POTENT AND SELECTIVE PHOSPHODIESTERASE IV INHIBITORS 99
HETEROCYCLIC-FUSED 3(2H)-PYRIDAZINONES AS POTENT AND SELECTIVE PDE IV INHIBITORS: FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS AND MOLECULAR MODELLING STUDIES 99
NOVEL 3-ARYLAMINO- AND 3-CYCLOALKYLAMINO-5,6-DIPHENYLPYRIDAZINES ACTIVE AS ACAT INHIBITORS 98
1,5,6,7-Tetrahydro-4H-indazol-4-ones as human neutrophil elastase (HNE) inhibitors 97
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain. 95
4,5-FUNCTIONALIZED 6-PHENYL-3(2H)-PIRIDAZINONES:SYNTHESIS AND EVALUATION OF ANTINOCICEPTIVE ACTIVITY 92
PDE5 Inhibitors and their applications 91
New 3,6-disubstituted pyrazolo[1,5-a]quinazolines as ligands to GABAA receptor subtype 91
A NEW TWO-STEP PROCEDURE FOR FUNCTIONALIZED-3(2H)-PIRIDAZINONES THROUGH HOMOLYTIC SUBSTITUTION OF 3-CHLOROPYRIDAZINES 90
5,6-DINITROPHENYL AND 5-AMINOPHENYL-6-NITROPHENYL ANALOGUES OF THE ACAT INHIBITOR 5,6-DIPHENYL-3-ALKYLAMINOPYRIDAZINONES 89
Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study 89
Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands 87
A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications 83
Exploration of Nitrogen Heterocycle Scaffolds for the Development of Potent Human Neutrophil Elastase Inhibitors 83
SYNTHESIS AND EVALUATION OF SOME 4,5-DISUBSTITUTED 6-PHENYL-3(2H)-PYRIDAZINONES AS HYPOTENSIVE AGENTS 81
Nonsteroidal Anti-Inflammatory Drugs-1-Phenylethylamine Diastereomeric Salts: A Systematic Solid-State Investigation 79
4-amino-5-vinyl-3(2H)-pyridazinones and related compounds: synthesis and evaluation of antinociceptive activity 78
4,5-FUNCTIONALIZED-3(2H)PYRIDAZINONES: NEW SYNTHETIC AND PHARMACOLOGICAL ASPECTS 76
New synthetic approach to pyrazolo[3,4-d]pyridazin-7(6H)-one ring system 76
'Proximity frequencies' a new parameter to evaluate the profile of GABAAR modulators 76
Synthesis, biological evaluation, molecular modeling, and structural analysis of new pyrazole and pyrazolone derivatives as N-formyl peptide receptors agonists 76
Novel formyl peptide receptor (FPR) agonists with pyridinone and pyrimidindione scaffolds that are potentially useful for the treatment of rheumatoid arthritis 76
Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors 74
5,6-diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltranferase inhibitors 71
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity agents as potential agents for treatment of erectile dysfunction 70
New insights on the arylpiperazinylalkyl pyridazinone ET1 as potent antinociceptive and anti-inflammatory agent 69
Preparation of pyridazin-3(2H)-ones and their use as PDE4 inhibitors 68
Reductive cleavage of isoxazolo[3,4-d]pyridazinones: a synthetic approach to various 4,5-functionalized 3(2H)-pyridazinones 68
phenylpiperazinylalkylamino substituted pyridazinones as potent alpha 1 adrenoceptor antagonists 68
SYNTHESIS AND EVALUATION OF SOME PYRAZOLO[3,4-D]PYRIDAZINONES AND ANALOGUES AS PDE5 INHIBITORS POTENTIALLY USEFUL AS PERIPHERAL VASODILATOR 67
An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022 66
INDENOPYRIDAZINONE DERIVATIVES AS POTENTIAL ANTISECRETORY AND ANTIULCER AGENTS 66
Synthesis and evaluation of novel pyrrolo[2,3-d] and thieno[2,3-d]pyridazinones as in vitro antiproliferative agents 65
preparation of pyridazin-3(2H)-ones as phosphodiesterase 4 (PDE4) inhibitors 64
Design and synthesis of the first indole-based blockers of Panx-1 channel 64
Preparation of pyridazin-3(2H)-ones as phosphodiesterase 4 (PDE4) inhibitors 64
SYNTHESIS AND EVALUATION AS PLATELET AGGREGATION INHIBITORS OF 6-PHENYL-2,4-SUBSTITUTED-3(2H)-PYRIDAZINONES AND THEIR RIGID ANALOGUES BENZO[H]CINNOLIN-3,5-DIONES 63
Isoxazolo[3,4-d]pyridazin-7-(6H)-ones. Synthesis of 3-unsubstituted derivatives: a reinvestigation. 63
NEW SYNTHESIS OF DIFFERENTLY FUSED PYRIDAZINONQUINOLINES 63
SYNTHESIS OF 4,5 FUNCTIONALIZED-2-METHYL-6-(SUBSTITUTED ARYL)-3(2H)-PYRIDAZINONES: A NEW GROUP OF POTENT PLATELET AGGREGATION INHIBITORS 63
Alpha-2-agonist as analgesic agents 63
iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer 61
Molecular manipulation of the 1,5,6,7-tetrahydro-4 H -indazol-4-one scaffold to obtain new human neutrophil elastase (HNE) inhibitors 59
New Panx-1 Blockers: Synthesis, Biological Evaluation and Molecular Dynamic Studies 58
Design, Synthesis and Pharmacological Evaluation of New Quinoline-Based Panx-1 Channel Blockers 57
Editorial: Serine protease inhibitors and their therapeutic applications 57
Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening 54
Pyridazin-3(2H)-one derivatives as novel PDE IV inhibitors 47
Synthesis and inverse virtual screening of new bi-cyclic structures towards cancer-relevant cellular targets 47
Totale 11.365
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Categoria #
all - tutte 31.879
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.879
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.287 0 0 0 0 212 212 170 236 160 104 153 40
2020/20211.540 121 104 72 198 69 181 79 124 170 239 73 110
2021/2022756 19 51 43 34 29 45 22 51 34 54 183 191
2022/20231.895 187 354 78 137 186 335 240 121 157 6 66 28
2023/2024668 19 79 123 37 37 103 15 149 14 52 28 12
2024/20252.996 180 529 275 768 1.244 0 0 0 0 0 0 0
Totale 11.912