Dithiocarbamates (DTCs) are chemically referred to as functional groups analogs to the carbamates, containing sulfur instead of oxygen atoms. Herein we report the kinetic results of a series of DTC-containing compounds tested on α and β-carbonic anhydrases (EC 4.2.1.1). The DTCs binding mode was also investigated by means of crystallographic experiments of the selected DTC 10, 11 and 14 in adduct with human carbonic anhydrase II.
Next-generation dithiocarbamate carbonic anhydrase inhibitors / Carta, Fabrizio*; Bozdag, Murat; Tanc, Muhammet; Supuran, Claudiu. - ELETTRONICO. - (2014), pp. 114-130. [10.4155/fseb2013.13.14]
Next-generation dithiocarbamate carbonic anhydrase inhibitors
Carta, Fabrizio;Bozdag, Murat;Supuran, Claudiu
2014
Abstract
Dithiocarbamates (DTCs) are chemically referred to as functional groups analogs to the carbamates, containing sulfur instead of oxygen atoms. Herein we report the kinetic results of a series of DTC-containing compounds tested on α and β-carbonic anhydrases (EC 4.2.1.1). The DTCs binding mode was also investigated by means of crystallographic experiments of the selected DTC 10, 11 and 14 in adduct with human carbonic anhydrase II.
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