VARANO, FLAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 9.614
EU - Europa 5.510
AS - Asia 4.586
SA - Sud America 675
AF - Africa 141
OC - Oceania 80
Continente sconosciuto - Info sul continente non disponibili 6
Totale 20.612
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Nazione #
US - Stati Uniti d'America 9.515
RU - Federazione Russa 2.080
SG - Singapore 1.070
CN - Cina 996
VN - Vietnam 830
IT - Italia 729
HK - Hong Kong 723
IE - Irlanda 685
BR - Brasile 546
SE - Svezia 493
PL - Polonia 360
KR - Corea 340
DE - Germania 247
FI - Finlandia 220
IN - India 220
FR - Francia 213
UA - Ucraina 193
GB - Regno Unito 111
JP - Giappone 87
AU - Australia 75
JO - Giordania 67
AR - Argentina 63
CA - Canada 58
NL - Olanda 57
BD - Bangladesh 48
ID - Indonesia 41
TR - Turchia 41
ES - Italia 40
ZA - Sudafrica 32
CI - Costa d'Avorio 29
MX - Messico 28
IQ - Iraq 26
MA - Marocco 24
CH - Svizzera 18
PK - Pakistan 17
CO - Colombia 15
SC - Seychelles 15
EC - Ecuador 12
EG - Egitto 12
BE - Belgio 11
VE - Venezuela 11
TH - Thailandia 10
EE - Estonia 8
PH - Filippine 8
PY - Paraguay 8
AZ - Azerbaigian 7
AT - Austria 6
CL - Cile 6
EU - Europa 6
NG - Nigeria 6
AE - Emirati Arabi Uniti 5
AL - Albania 5
DK - Danimarca 5
KG - Kirghizistan 5
KZ - Kazakistan 5
PE - Perù 5
SN - Senegal 5
UY - Uruguay 5
UZ - Uzbekistan 5
AO - Angola 4
BO - Bolivia 4
CZ - Repubblica Ceca 4
LT - Lituania 4
NZ - Nuova Zelanda 4
SA - Arabia Saudita 4
BJ - Benin 3
IL - Israele 3
IR - Iran 3
MY - Malesia 3
OM - Oman 3
PS - Palestinian Territory 3
PT - Portogallo 3
RO - Romania 3
SY - Repubblica araba siriana 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
CR - Costa Rica 2
ET - Etiopia 2
GR - Grecia 2
GT - Guatemala 2
JM - Giamaica 2
KE - Kenya 2
LB - Libano 2
MM - Myanmar 2
MU - Mauritius 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
AW - Aruba 1
BH - Bahrain 1
BY - Bielorussia 1
BZ - Belize 1
CY - Cipro 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GE - Georgia 1
HN - Honduras 1
HR - Croazia 1
Totale 20.603
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Città #
Santa Clara 2.341
Ashburn 1.060
Singapore 726
Fairfield 687
Dublin 684
Hong Kong 606
Chandler 508
Warsaw 356
Dong Ket 342
Seoul 326
Cambridge 322
Seattle 316
San Jose 311
Woodbridge 301
Beijing 287
Wilmington 283
Jacksonville 280
Houston 236
Ho Chi Minh City 168
The Dalles 155
Mumbai 151
Ann Arbor 140
Los Angeles 140
Princeton 140
Florence 137
Hefei 132
Buffalo 123
Boston 119
Altamura 113
Lauterbourg 113
Hanoi 110
Lawrence 92
Dallas 87
Tokyo 81
Moscow 74
Helsinki 73
Melbourne 72
New York 68
Boardman 66
Munich 64
Shanghai 64
Council Bluffs 62
Kent 52
Paris 48
Medford 45
San Diego 41
Turku 37
São Paulo 32
Orem 31
West Jordan 30
Abidjan 29
Clifton 29
Milan 27
Chennai 25
Jakarta 24
Chicago 23
Redondo Beach 23
Rome 22
Norwalk 21
Barcelona 19
Johannesburg 19
Toronto 19
Da Nang 18
Camerino 17
Guangzhou 17
Rio de Janeiro 17
Bern 16
London 16
Auburn Hills 15
Falls Church 15
Haiphong 15
Amsterdam 14
Casablanca 14
Ferrara 14
Izmir 14
Washington 14
Belo Horizonte 13
Atlanta 12
Baghdad 12
Brooklyn 12
Frankfurt am Main 12
Montreal 12
Thái Bình 12
Denver 11
Hillsboro 11
Phoenix 11
San Francisco 11
Shenzhen 11
Tianjin 11
Turin 11
Yubileyny 11
Biên Hòa 10
Curitiba 10
Gavirate 10
Romola 10
Andover 9
Brussels 9
Dearborn 9
Hải Dương 9
Lappeenranta 9
Totale 13.586
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Nome #
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. 319
1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships 290
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists. 266
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype 265
Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists. 251
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists 248
The 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold to Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological and Ligand-Receptor Modeling Studies. 247
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives. 242
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold to obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition† 238
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation 219
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 218
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles 217
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII 215
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies. 213
Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway 212
1,2,4-Triazolo[4,3-a]pyrazin-3-one as a new scaffold to develop potent adenosine receptor antagonists 210
“1,2,4-TRIAZOLO[1,5-A]QUINOXALINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AS ADENOSINE RECEPTOR ANTAGONISTS” 207
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation and molecular modeling study 204
1,2,4-Triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure–affinity relationships and molecular modeling studies 203
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes 201
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity 195
1,2,4-triazolo[4,3-a]quinoxalin-1-one as a framework to obtain potent and selective A1, A2A and A3 adenosine receptor antagonists 193
Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus 192
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists 190
Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity 190
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain 188
Development of novel pyridazinone-based adenosine receptor ligands 187
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors 186
Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies 183
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones. Excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity 180
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists 178
Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. 178
2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists 177
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists 175
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists. 174
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: synthesis and structure-activity relationships 174
Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis 171
CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases 171
Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity. 170
2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists 169
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2Breceptor 169
Inhibition of A2Aadenosine receptor signaling in cancer cells proliferation by the novel antagonist TP455 169
“3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists” 168
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. 168
Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site. 167
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity 166
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies 166
Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype 166
4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors. 165
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells 162
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies 162
SYNTHESIS OF SOME 2-ARYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONES AS TOOLS TO DEFINE THE ESSENTIAL PHARMACOPHORIC DESCRIPTORS OF A BENZODIAZEPINE RECEPTOR LIGAND. 161
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation 161
Nuovi tiazoli[5,4-d]pirimidin derivati quali agonisti inversi dei recettori A2A dell'adenosina 159
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 158
Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression 158
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta 156
Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies 156
G protein-coupled receptors as potential drug target: from receptor topology to rational drug design, an in silico approach 153
Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus 152
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor 152
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-CYCLOALKYLAMINO-1,2,4-TRIAZOLO[4,3-A]QUINOXALIN-1-ONE DERIVATIVES AS A1 AND A3 ADENOSINE RECEPTOR ANTAGONISTS. 151
4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as New Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 151
Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines. 150
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies. 149
Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents 149
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists. 148
4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives 148
Piperazine-and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine a2a receptor inverse agonists 147
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies 145
New 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 142
Synthesis and Pharmacological Studies at the Gly/NMDA, AMPA and Kainate Receptors of New Oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring 142
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors. 142
Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and –imidazol-4-ones. 141
Tandem 3D-QSARs Approach as a Valuable Tool To Predict Binding Affinity Data: Design of New Gly/NMDA Receptor Antagonists as a Key Study. 140
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. 138
Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity. 138
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists 138
Competitive AMPA receptor antagonists. 136
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor 133
Scouting Human A3 Adenosine Receptor Antagonist Binding Mode Using a Molecular Simplification Approach: From Triazoloquinoxaline to a Pyrimidine Skeleton as a Key Study 132
2-Arylimidazo[1,2-a]pyrazin-8-amino derivatives as high-affinity fluorescent human A3 adenosine receptor antagonists with potential neuroprotective properties 132
Thiazolo[5,4-d]pyrimidin-7-amino derivatives as dual human adenosine A2A/A1 receptor antagonists. 132
Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity. 131
Synthesis, Ionotropic glutamate receptor binding affinity and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogue of TQX-173 131
Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases 130
Competitive Gly/NMDA receptor antagonists 130
New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists. 130
New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists. 130
Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders 130
NUOVI TIAZOLO[5,4-d]PIRIMIDIN DERIVATI QUALI AGONISTI INVERSI DEI RECETTORI A2A DELL’ADENOSINA 129
Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists. 127
2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors 127
Amino-3, 5-dicyanopyridines targeting the adenosine receptors. Ranging from pan ligands to combined A1/A2B partial agonists 127
Synthesis and Structure-Activity Relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 125
Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A2A adenosine receptor antagonists. 124
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents 123
9-Eteroaril-4,5-diidro-4-oxo-1,2,4-triazolo[1,5-a]chinossaline-2-carbossilati antagonisti dei recettori degli amminoacidi eccitatori 121
Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists. 120
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures 117
Totale 16.976
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Categoria #
all - tutte 58.572
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 58.572
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021418 0 0 0 0 0 0 0 0 0 0 0 418
2021/2022865 40 102 58 46 31 28 32 51 40 44 149 244
2022/20232.251 216 369 118 149 169 404 317 134 235 13 83 44
2023/20241.079 44 89 150 43 46 299 42 134 36 89 61 46
2024/20256.379 193 692 382 840 1.931 929 118 376 261 198 253 206
2025/20265.869 765 901 503 671 683 201 693 315 485 453 197 2
Totale 20.810