VARANO, FLAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 10.876
EU - Europa 6.477
AS - Asia 4.635
SA - Sud America 694
Continente sconosciuto - Info sul continente non disponibili 206
AF - Africa 148
OC - Oceania 82
Totale 23.118
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Nazione #
US - Stati Uniti d'America 10.678
RU - Federazione Russa 2.080
IT - Italia 1.673
SG - Singapore 1.074
CN - Cina 1.001
VN - Vietnam 830
HK - Hong Kong 730
IE - Irlanda 686
BR - Brasile 550
SE - Svezia 495
PL - Polonia 362
KR - Corea 340
DE - Germania 248
IN - India 222
FI - Finlandia 221
FR - Francia 216
UA - Ucraina 193
CA - Canada 125
GB - Regno Unito 118
JP - Giappone 89
AU - Australia 77
JO - Giordania 67
AR - Argentina 65
BD - Bangladesh 63
NL - Olanda 60
ID - Indonesia 44
TR - Turchia 42
ES - Italia 40
ZA - Sudafrica 32
MX - Messico 31
CI - Costa d'Avorio 29
IQ - Iraq 26
MA - Marocco 24
CO - Colombia 22
SC - Seychelles 19
CH - Svizzera 18
PK - Pakistan 17
VE - Venezuela 14
EC - Ecuador 13
EG - Egitto 12
TH - Thailandia 12
BE - Belgio 11
GT - Guatemala 10
PY - Paraguay 9
EE - Estonia 8
JM - Giamaica 8
PH - Filippine 8
AZ - Azerbaigian 7
AE - Emirati Arabi Uniti 6
AT - Austria 6
CL - Cile 6
CR - Costa Rica 6
EU - Europa 6
NG - Nigeria 6
SA - Arabia Saudita 6
UY - Uruguay 6
AL - Albania 5
DK - Danimarca 5
KG - Kirghizistan 5
KZ - Kazakistan 5
PE - Perù 5
PT - Portogallo 5
SN - Senegal 5
UZ - Uzbekistan 5
AO - Angola 4
BO - Bolivia 4
CZ - Repubblica Ceca 4
LB - Libano 4
LT - Lituania 4
MY - Malesia 4
NZ - Nuova Zelanda 4
BJ - Benin 3
IL - Israele 3
IR - Iran 3
KE - Kenya 3
MM - Myanmar 3
OM - Oman 3
PS - Palestinian Territory 3
RO - Romania 3
SY - Repubblica araba siriana 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
ET - Etiopia 2
GR - Grecia 2
HN - Honduras 2
HR - Croazia 2
MU - Mauritius 2
NI - Nicaragua 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
TW - Taiwan 2
AG - Antigua e Barbuda 1
AI - Anguilla 1
AW - Aruba 1
BH - Bahrain 1
BY - Bielorussia 1
BZ - Belize 1
Totale 22.898
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Città #
Santa Clara 2.363
Ashburn 1.271
Singapore 730
Fairfield 687
Dublin 684
Hong Kong 608
Chandler 508
San Jose 484
Warsaw 357
Dong Ket 342
Seoul 326
Cambridge 322
Seattle 319
Woodbridge 302
Beijing 289
Jacksonville 284
Wilmington 283
Milan 279
Houston 237
Council Bluffs 181
Ho Chi Minh City 168
Florence 160
Rome 156
The Dalles 155
Los Angeles 151
Mumbai 151
Ann Arbor 140
Princeton 140
Hefei 132
Buffalo 126
Boston 123
Altamura 113
Lauterbourg 113
Hanoi 110
Dallas 100
Lawrence 92
Tokyo 83
New York 81
Moscow 74
Helsinki 73
Melbourne 73
Boardman 72
Munich 64
Shanghai 64
Chicago 56
Kent 52
Paris 49
Medford 46
Phoenix 45
San Diego 44
Turin 39
Turku 37
Naples 36
Bologna 34
Columbus 34
São Paulo 32
Toronto 32
Orem 31
West Jordan 30
Abidjan 29
Clifton 29
Chennai 25
Jakarta 24
Redondo Beach 23
Verona 22
Norwalk 21
Palermo 20
Venice 20
Barcelona 19
Johannesburg 19
Montreal 19
Da Nang 18
Rio de Janeiro 18
Camerino 17
Guangzhou 17
London 17
Washington 17
Atlanta 16
Bern 16
Brooklyn 16
Auburn Hills 15
Falls Church 15
Haiphong 15
Amsterdam 14
Belo Horizonte 14
Cagliari 14
Casablanca 14
Denver 14
Ferrara 14
Izmir 14
Padua 14
Catania 13
Figino 13
Frankfurt am Main 13
Miano 13
San Francisco 13
Baghdad 12
Bari 12
Thái Bình 12
Genoa 11
Totale 14.858
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Nome #
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. 336
1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships 303
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists. 290
Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists. 282
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype 281
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives. 267
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold to obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition† 260
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists 258
The 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold to Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological and Ligand-Receptor Modeling Studies. 257
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 242
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII 239
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation 234
Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway 232
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles 231
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies. 231
1,2,4-Triazolo[4,3-a]pyrazin-3-one as a new scaffold to develop potent adenosine receptor antagonists 226
“1,2,4-TRIAZOLO[1,5-A]QUINOXALINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AS ADENOSINE RECEPTOR ANTAGONISTS” 220
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes 219
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation and molecular modeling study 217
1,2,4-Triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure–affinity relationships and molecular modeling studies 215
Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity 214
Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies 205
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity 205
1,2,4-triazolo[4,3-a]quinoxalin-1-one as a framework to obtain potent and selective A1, A2A and A3 adenosine receptor antagonists 204
CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases 203
Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. 203
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain 202
Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus 199
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists 198
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones. Excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity 195
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists 194
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. 194
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists 193
Development of novel pyridazinone-based adenosine receptor ligands 191
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors 190
2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists 190
“3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists” 187
Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity. 187
Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site. 185
2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists 185
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: synthesis and structure-activity relationships 184
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2Breceptor 184
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists. 181
Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype 181
Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis 180
Inhibition of A2Aadenosine receptor signaling in cancer cells proliferation by the novel antagonist TP455 180
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation 177
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity 177
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies 177
Nuovi tiazoli[5,4-d]pirimidin derivati quali agonisti inversi dei recettori A2A dell'adenosina 176
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies 176
Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies 175
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells 175
4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as New Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 174
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 173
4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors. 173
Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus 170
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta 169
SYNTHESIS OF SOME 2-ARYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONES AS TOOLS TO DEFINE THE ESSENTIAL PHARMACOPHORIC DESCRIPTORS OF A BENZODIAZEPINE RECEPTOR LIGAND. 168
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor 168
Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression 167
G protein-coupled receptors as potential drug target: from receptor topology to rational drug design, an in silico approach 165
Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents 164
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies. 161
Synthesis and Pharmacological Studies at the Gly/NMDA, AMPA and Kainate Receptors of New Oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring 160
Piperazine-and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine a2a receptor inverse agonists 160
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists. 159
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies 158
4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives 158
Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders 158
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. 157
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-CYCLOALKYLAMINO-1,2,4-TRIAZOLO[4,3-A]QUINOXALIN-1-ONE DERIVATIVES AS A1 AND A3 ADENOSINE RECEPTOR ANTAGONISTS. 157
Thiazolo[5,4-d]pyrimidin-7-amino derivatives as dual human adenosine A2A/A1 receptor antagonists. 157
Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines. 156
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors. 155
New 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 154
Tandem 3D-QSARs Approach as a Valuable Tool To Predict Binding Affinity Data: Design of New Gly/NMDA Receptor Antagonists as a Key Study. 154
Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and –imidazol-4-ones. 154
Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity. 154
Scouting Human A3 Adenosine Receptor Antagonist Binding Mode Using a Molecular Simplification Approach: From Triazoloquinoxaline to a Pyrimidine Skeleton as a Key Study 152
2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors 151
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists 151
Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases 150
Competitive AMPA receptor antagonists. 150
NUOVI TIAZOLO[5,4-d]PIRIMIDIN DERIVATI QUALI AGONISTI INVERSI DEI RECETTORI A2A DELL’ADENOSINA 149
Competitive Gly/NMDA receptor antagonists 147
Aminopyridine-3,5-dicarbonitriles as non-nucleoside adenosine A1 receptor agonists. 145
Synthesis, Ionotropic glutamate receptor binding affinity and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogue of TQX-173 144
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor 144
2-Arylimidazo[1,2-a]pyrazin-8-amino derivatives as high-affinity fluorescent human A3 adenosine receptor antagonists with potential neuroprotective properties 144
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures 143
New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists. 143
Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity. 142
Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A2A adenosine receptor antagonists. 139
Pirazolo[1,5-c]chinazoline 1-carbossi sostituite: nuovi antagonisti del recettore Gly/NMDA 138
Amino-3, 5-dicyanopyridines targeting the adenosine receptors. Ranging from pan ligands to combined A1/A2B partial agonists 138
Synthesis and Structure-Activity Relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 138
New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists. 137
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents 137
Synthesis and A1 and A2A binding activity of some pyrano[2,3-c]pyrazol-4-ones. 134
Totale 18.506
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Categoria #
all - tutte 65.859
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.859
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022665 0 0 0 46 31 28 32 51 40 44 149 244
2022/20232.251 216 369 118 149 169 404 317 134 235 13 83 44
2023/20241.079 44 89 150 43 46 299 42 134 36 89 61 46
2024/20256.379 193 692 382 840 1.931 929 118 376 261 198 253 206
2025/20266.886 765 901 503 671 683 201 693 315 485 453 197 1.019
2026/20271.291 304 214 732 41 0 0 0 0 0 0 0 0
Totale 23.118