VARANO, FLAVIA
 Distribuzione geografica
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Continente #
NA - Nord America 9.959
EU - Europa 6.434
AS - Asia 4.617
SA - Sud America 677
Continente sconosciuto - Info sul continente non disponibili 206
AF - Africa 145
OC - Oceania 80
Totale 22.118
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Nazione #
US - Stati Uniti d'America 9.784
RU - Federazione Russa 2.080
IT - Italia 1.644
SG - Singapore 1.073
CN - Cina 1.000
VN - Vietnam 830
HK - Hong Kong 730
IE - Irlanda 685
BR - Brasile 548
SE - Svezia 493
PL - Polonia 362
KR - Corea 340
DE - Germania 248
FI - Finlandia 221
IN - India 221
FR - Francia 214
UA - Ucraina 193
CA - Canada 116
GB - Regno Unito 113
JP - Giappone 88
AU - Australia 75
JO - Giordania 67
AR - Argentina 63
BD - Bangladesh 62
NL - Olanda 59
ID - Indonesia 41
TR - Turchia 41
ES - Italia 40
ZA - Sudafrica 32
CI - Costa d'Avorio 29
MX - Messico 29
IQ - Iraq 26
MA - Marocco 24
SC - Seychelles 19
CH - Svizzera 18
PK - Pakistan 17
CO - Colombia 15
EC - Ecuador 12
EG - Egitto 12
BE - Belgio 11
VE - Venezuela 11
TH - Thailandia 10
EE - Estonia 8
GT - Guatemala 8
PH - Filippine 8
PY - Paraguay 8
AZ - Azerbaigian 7
AE - Emirati Arabi Uniti 6
AT - Austria 6
CL - Cile 6
CR - Costa Rica 6
EU - Europa 6
NG - Nigeria 6
AL - Albania 5
DK - Danimarca 5
JM - Giamaica 5
KG - Kirghizistan 5
KZ - Kazakistan 5
PE - Perù 5
SN - Senegal 5
UY - Uruguay 5
UZ - Uzbekistan 5
AO - Angola 4
BO - Bolivia 4
CZ - Repubblica Ceca 4
LT - Lituania 4
NZ - Nuova Zelanda 4
SA - Arabia Saudita 4
BJ - Benin 3
IL - Israele 3
IR - Iran 3
MY - Malesia 3
OM - Oman 3
PS - Palestinian Territory 3
PT - Portogallo 3
RO - Romania 3
SY - Repubblica araba siriana 3
TN - Tunisia 3
TT - Trinidad e Tobago 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
ET - Etiopia 2
GR - Grecia 2
KE - Kenya 2
LB - Libano 2
MM - Myanmar 2
MU - Mauritius 2
SK - Slovacchia (Repubblica Slovacca) 2
SV - El Salvador 2
TW - Taiwan 2
AG - Antigua e Barbuda 1
AW - Aruba 1
BH - Bahrain 1
BY - Bielorussia 1
BZ - Belize 1
CY - Cipro 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GE - Georgia 1
Totale 21.906
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Città #
Santa Clara 2.348
Ashburn 1.128
Singapore 729
Fairfield 687
Dublin 684
Hong Kong 608
Chandler 508
Warsaw 357
Dong Ket 342
Seoul 326
San Jose 324
Cambridge 322
Seattle 317
Woodbridge 301
Beijing 288
Wilmington 283
Jacksonville 281
Milan 277
Houston 236
Ho Chi Minh City 168
Florence 157
The Dalles 155
Mumbai 151
Rome 151
Los Angeles 145
Ann Arbor 140
Princeton 140
Hefei 132
Buffalo 125
Boston 119
Altamura 113
Lauterbourg 113
Hanoi 110
Dallas 92
Lawrence 92
Tokyo 82
Moscow 74
Helsinki 73
Melbourne 73
Boardman 70
New York 70
Council Bluffs 64
Munich 64
Shanghai 64
Kent 52
Paris 48
Medford 45
San Diego 41
Turin 37
Turku 37
Naples 36
Bologna 33
São Paulo 32
Orem 31
Toronto 31
West Jordan 30
Abidjan 29
Clifton 29
Chicago 28
Chennai 25
Jakarta 24
Redondo Beach 23
Verona 22
Norwalk 21
Palermo 20
Venice 20
Barcelona 19
Johannesburg 19
Da Nang 18
Camerino 17
Guangzhou 17
Rio de Janeiro 17
Bern 16
London 16
Auburn Hills 15
Falls Church 15
Haiphong 15
Montreal 15
Washington 15
Amsterdam 14
Belo Horizonte 14
Casablanca 14
Ferrara 14
Izmir 14
Padua 14
Cagliari 13
Frankfurt am Main 13
Miano 13
Phoenix 13
Atlanta 12
Baghdad 12
Bari 12
Brooklyn 12
Catania 12
Figino 12
Thái Bình 12
Denver 11
Genoa 11
Hillsboro 11
San Francisco 11
Totale 14.255
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Nome #
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists. 332
1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships 298
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists. 282
Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as AMPA receptor antagonists. 276
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype 275
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives. 257
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists 254
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold to obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition† 250
The 1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold to Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological and Ligand-Receptor Modeling Studies. 249
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 230
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino Derivatives As New Potent and Selective Human A3Adenosine Receptor Antagonists. Molecular Modeling Studies and Pharmacological Evaluation 228
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles 228
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII 228
Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway 223
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies. 222
1,2,4-Triazolo[4,3-a]pyrazin-3-one as a new scaffold to develop potent adenosine receptor antagonists 220
Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes 216
“1,2,4-TRIAZOLO[1,5-A]QUINOXALINE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AS ADENOSINE RECEPTOR ANTAGONISTS” 215
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation and molecular modeling study 212
1,2,4-Triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure–affinity relationships and molecular modeling studies 209
Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity 205
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity 203
Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological and Molecular Modeling Studies 199
1,2,4-triazolo[4,3-a]quinoxalin-1-one as a framework to obtain potent and selective A1, A2A and A3 adenosine receptor antagonists 199
Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain 199
Functional characterization of a novel adenosine A2B receptor agonist on short-term plasticity and synaptic inhibition during oxygen and glucose deprivation in the rat CA1 hippocampus 195
Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. 193
CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases 191
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists 191
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists 189
Development of novel pyridazinone-based adenosine receptor ligands 189
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors 188
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones. Excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity 187
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists 186
“3-Hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists” 180
Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity. 180
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2Breceptor 179
2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists 177
Inhibition of A2Aadenosine receptor signaling in cancer cells proliferation by the novel antagonist TP455 177
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: synthesis and structure-activity relationships 176
Adenosine Receptor Ligands as Potential Therapeutic Agents for Impaired Wound Healing and Fibrosis 175
Benzodiazepine binding activity of some tricyclic heteroarometic systems to define the hydrogen bonding strength of the proton donors of the receptor site. 175
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists. 175
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: Structural investigations at the 5-position to target human A1 and A2A adenosine receptors. Molecular modeling and pharmacological studies 173
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies 172
Aminopyridine-3,5-carbonitrile core for the design of new adenosine receptor agonists: structural exploration to target the A1 subtype 172
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation 171
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity 171
Nuovi tiazoli[5,4-d]pirimidin derivati quali agonisti inversi dei recettori A2A dell'adenosina 170
2-Aryl-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as new potent adenosine human A2A receptor antagonists 170
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new potent and selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. 170
4-Amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as New Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 169
4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3-a] quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors. 168
Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A 1 and A 2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells 168
Novel potent and highly selective human A3 adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies 167
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta 165
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 165
Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus 164
SYNTHESIS OF SOME 2-ARYL-1,2,4-TRIAZOLO[1,5-C][1,3]BENZOXAZIN-5-ONES AS TOOLS TO DEFINE THE ESSENTIAL PHARMACOPHORIC DESCRIPTORS OF A BENZODIAZEPINE RECEPTOR LIGAND. 162
G protein-coupled receptors as potential drug target: from receptor topology to rational drug design, an in silico approach 162
Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression 161
Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents 160
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor 159
Piperazine-and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine a2a receptor inverse agonists 157
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand-Receptor Modeling Studies. 156
Synthesis and Pharmacological Studies at the Gly/NMDA, AMPA and Kainate Receptors of New Oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring 154
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: Synthesis, structure–affinity relationships and molecular modeling studies 153
4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives 153
Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines. 152
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-CYCLOALKYLAMINO-1,2,4-TRIAZOLO[4,3-A]QUINOXALIN-1-ONE DERIVATIVES AS A1 AND A3 ADENOSINE RECEPTOR ANTAGONISTS. 152
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists. 152
Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders 152
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. 151
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors. 150
New 2-Arylpyrazolo[3,4-c]quinoline Derivatives as Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation and Ligand-Receptor Modeling Studies. 148
Tricyclic heteroaromatic systems. Synthesis and benzodiazepine receptor affinity of 2-substituted-1-benzopyrano[3,4-d]oxazol-4-ones, -thiazol-4-ones, and –imidazol-4-ones. 148
Tandem 3D-QSARs Approach as a Valuable Tool To Predict Binding Affinity Data: Design of New Gly/NMDA Receptor Antagonists as a Key Study. 147
2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors 146
Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity. 146
Scouting Human A3 Adenosine Receptor Antagonist Binding Mode Using a Molecular Simplification Approach: From Triazoloquinoxaline to a Pyrimidine Skeleton as a Key Study 146
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1and A2Aadenosine receptor antagonists/inverse agonists 143
NUOVI TIAZOLO[5,4-d]PIRIMIDIN DERIVATI QUALI AGONISTI INVERSI DEI RECETTORI A2A DELL’ADENOSINA 142
Competitive Gly/NMDA receptor antagonists 139
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor 139
Competitive AMPA receptor antagonists. 138
2-Arylimidazo[1,2-a]pyrazin-8-amino derivatives as high-affinity fluorescent human A3 adenosine receptor antagonists with potential neuroprotective properties 138
Once Upon a Time Adenosine and Its Receptors: Historical Survey and Perspectives as Potential Targets for Therapy in Human Diseases 137
Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity. 137
Synthesis, Ionotropic glutamate receptor binding affinity and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogue of TQX-173 137
New 5-heteroaryl-pyrazolo[4,3-d]pyrimidin-7-amines as dual human adenosine A1 and A2A receptor antagonists. 137
Amino-3, 5-dicyanopyridines targeting the adenosine receptors. Ranging from pan ligands to combined A1/A2B partial agonists 135
Thiazolo[5,4-d]pyrimidin-7-amino derivatives as dual human adenosine A2A/A1 receptor antagonists. 135
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives, new potent and selective human A3 adenosine receptor antagonists endowed with protective effect against oxaliplatin-induced apoptosis in rat astrocyte cell cultures 134
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents 133
New aminopyridine-3,5-dicarbonitirles as adenosine A2B receptor non-nucleoside agonists. 131
Synthesis and Structure-Activity Relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists. 131
Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A2A adenosine receptor antagonists. 130
Imidazo[1,2-a]pyrazine core for the design of new adenosine receptor antagonist: optimization of A3 affinity and structural exploration to target the A2A subtype 129
Sintesi e relazioni struttura-attività di derivati a struttura 2-aril-8-cloro-1,2,4-triazolo[1,5-a]chinossalinica quali antagonisti potenti e selettivi dei recettori A1 ed A3 dell’adenosina 128
Synthesis and biological evaluation of a series of quinazoline-2-carboxylic acids and quinazolin-2,4-diones as glycine-NMDA antagonists: a pharmacophore model based approach. 128
Totale 17.815
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Categoria #
all - tutte 62.208
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 62.208
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022865 40 102 58 46 31 28 32 51 40 44 149 244
2022/20232.251 216 369 118 149 169 404 317 134 235 13 83 44
2023/20241.079 44 89 150 43 46 299 42 134 36 89 61 46
2024/20256.379 193 692 382 840 1.931 929 118 376 261 198 253 206
2025/20266.886 765 901 503 671 683 201 693 315 485 453 197 1.019
2026/2027291 291 0 0 0 0 0 0 0 0 0 0 0
Totale 22.118