CHIARUGI, ALBERTO
 Distribuzione geografica
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Continente #
NA - Nord America 9.418
EU - Europa 4.856
AS - Asia 1.188
OC - Oceania 90
AF - Africa 35
SA - Sud America 11
Continente sconosciuto - Info sul continente non disponibili 1
Totale 15.599
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Nazione #
US - Stati Uniti d'America 9.395
RU - Federazione Russa 1.818
PL - Polonia 906
IE - Irlanda 576
IT - Italia 454
SE - Svezia 453
SG - Singapore 366
HK - Hong Kong 282
CN - Cina 255
CH - Svizzera 206
FI - Finlandia 114
DE - Germania 113
IN - India 91
AU - Australia 90
GB - Regno Unito 85
UA - Ucraina 80
TR - Turchia 71
JO - Giordania 45
CI - Costa d'Avorio 31
ID - Indonesia 28
VN - Vietnam 26
CA - Canada 23
BE - Belgio 16
NL - Olanda 15
BR - Brasile 9
FR - Francia 9
KR - Corea 8
JP - Giappone 7
RO - Romania 4
TW - Taiwan 4
CO - Colombia 2
ES - Italia 2
IR - Iran 2
LU - Lussemburgo 2
MU - Mauritius 2
PH - Filippine 2
DK - Danimarca 1
EG - Egitto 1
EU - Europa 1
HR - Croazia 1
IL - Israele 1
LT - Lituania 1
SC - Seychelles 1
Totale 15.599
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Città #
Santa Clara 2.057
Fairfield 1.241
Warsaw 906
Chandler 621
Woodbridge 585
Dublin 576
Ashburn 562
Seattle 540
Cambridge 517
Houston 418
Wilmington 383
Singapore 286
Bern 205
Ann Arbor 193
Altamura 161
Lawrence 160
Hong Kong 157
Princeton 148
Jacksonville 137
Medford 109
Melbourne 90
Dearborn 87
Mumbai 86
Boardman 85
Buffalo 84
Boston 72
San Diego 71
Beijing 68
Florence 67
Izmir 64
Shanghai 56
Moscow 50
Norwalk 33
Abidjan 31
Kent 29
Jakarta 28
Falls Church 25
Milan 25
Dong Ket 24
Hillsboro 20
London 20
New York 18
Toronto 18
Brussels 16
Rome 16
Yubileyny 14
Andover 13
Los Angeles 11
Tappahannock 10
Hefei 9
Laurel 9
Centro 8
Chicago 7
Helsinki 7
Nanjing 7
Phoenix 7
West Jordan 7
Auburn Hills 6
Frankfurt Am Main 6
Frankfurt am Main 6
Gavirate 6
Kunming 6
Prato 6
Seoul 6
Fontebuona 5
Guangzhou 5
Ardea 4
Mountain View 4
Munich 4
Redmond 4
São Paulo 4
Timisoara 4
Wuhan 4
Düsseldorf 3
Hounslow 3
Itanhangá 3
Jinan 3
Morgantown 3
Ottawa 3
Portland 3
Quartu Sant'Elena 3
Redwood City 3
Salerno 3
San Mateo 3
Shenyang 3
Tokyo 3
Vaglia 3
Wandsworth 3
Washington 3
Acton 2
Barcelona 2
Barranquilla 2
Boulder 2
Bremen 2
Brescia 2
Catania 2
Catanzaro 2
Changsha 2
Chongqing 2
Civitavecchia 2
Totale 11.404
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Nome #
Insight into molecular and functional properties of NMNAT3 reveals new hints of NAD homeostasis within human mitochondria 257
Interplay between histone acetylation/deacetylation and poly(ADPribosyl)ation in the development of ischemic tolerance in vitro 241
Activation of the histaminergic H3 receptor induces phosphorylation of the Akt/GSK-3 beta pathway in cultured cortical neurons and protects against neurotoxic insults. 229
1B-DMT1(-)IRE Expression During Brain Ischemia Contributes to Cell Death Mediated by NF-kB/RelA Acetylation at Lys310 213
Indoleamine 2,3-dioxygenase+ cells correspond to the BDCA2+ plasmacytoid dendritic cells in human melanoma sentinel nodes 173
Comparison of the Anti-Inflammatory and Cytotoxic Potential of Different Corticosteroid Eye Drop Preparations 166
Neuroimmunological characterization of a mouse model of primary progressive experimental autoimmune encephalomyelitis and effects of immunosuppressive or neuroprotective strategies on disease evolution 163
Trigeminal ganglion transcriptome analysis in 2 rat models of medication-overuse headache reveals coherent and widespread induction of pronociceptive gene expression patterns 163
Dexpramipexole improves bioenergetics and outcome in experimental stroke 162
Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death 154
Increase in the level of proinflammatory cytokine hmgb1 in nasal fluids of patients with rhinitis and its sequestration by glycyrrhizin induces eosinophil cell death 154
Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites 151
Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia. 148
Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase. 146
Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. 145
The NAD metabolome - a key determinant of cancer cell biology. 145
A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. 143
Repurposing of dexpramipexole to treatment of neonatal hypoxic/ischemic encephalopathy 143
Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription 142
"Simple but not simpler": toward a unified picture of energy requirements in cell death. 141
Dexpramipexole enhances hippocampal synaptic plasticity and memory in the rat 138
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives 135
Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis 132
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis 130
PARP inhibition delays progression of mitochondrial encephalopathy in mice 129
Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor. 128
The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension. 128
Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes 128
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. 125
Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance 125
Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines. 124
Ischemic Neuroprotection by TRPV1 Receptor-Induced Hypothermia 124
Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study 124
Histone Deacetylase (HDAC) Inhibitors Reduce the Glial Inflammatory Response In Vitro and In Vivo 123
Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia 123
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. 122
CoQ10-containing eye drops prevent UVB-induced cornea cell damage and increase cornea wound healing by preserving mitochondrial function 122
Update on the pathophysiology and treatment of rhinogenic headache: Focus on the ibuprofen/pseudoephedrine combination 122
Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: A post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial 121
Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice 121
Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation. 120
Recent Advances in Pediatric Use of Oral Paracetamol in Fever and Pain Management 119
Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice. 119
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis. 118
Poly (ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia 118
Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure 118
High expression of indoleamine 2,3-dioxygenase gene in prostate cancer. 118
IDENTIFICATION AND MEASUREMENT OF OXINDOLE (2-INDOLINONE) IN THE MAMMALIAN BRAIN AND OTHER RAT ORGANS 117
Antidromic vasodilatation and the migraine mechanism 117
Effects of Class II-Selective Histone Deacetylase Inhibitor on Neuromuscular Function and Disease Progression in SOD1-ALS Mice 117
AMP-dependent hypothermia affords protection from ischemic brain injury. 117
Long-term suppression of EAE relapses by pharmacological impairment of epitope spreading 117
Functional study in a yeast model of a novel succinate-dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. 116
Dysregulation of sphingosine 1 phosphate receptor-1 (S1P1) signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS rebound. 116
Studies on the pharmacological properties of oxindole (2-hydroxyindole) and 5-hydroxyindole: are they involved in hepatic encephalopathy? 115
Poly(ADP-ribosyl)ation and stroke. 115
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages. 114
Post onset, oral rapamycin treatment delays development of mitochondrial encephalopathy only at supramaximal doses 114
Intrinsic mechanisms of poly(ADP-ribose) neurotoxicity: three hypotheses. 114
Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation 114
Therapeutic hypothermia: Turning humans into cold-blooded ectotherms via adenosine receptors 113
Acute and chronic triptan exposure neither alters rodent cerebral blood flow nor worsens ischemic brain injury 112
On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. 112
Carboxymethyl beta-glucan binds to corneal epithelial cells and increases cell adhesion to laminin and resistance to oxidative stress. 111
Detection and Pharmacological Modulation of Nicotinamide Mononucleotide (NMN) in vitro and in vivo 110
Poly(ADP-ribose) polymerase as a key player in excitotoxicity and post-ischemic brain damage 109
Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles: In vitro and in vivo evaluation 109
Studies on the pharmacological properties of oxindole (2-hydroxyindole) and 5-hydroxyindole: are they involved in hepatic encephalopathy? 108
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice 108
INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE BY GALLOTANNIN SELECTIVELY UP-REGULATES EXPRESSION OF PRO-INFLAMMATORY GENES. 107
Glucose deprivation converts poly(ADP-ribose) polymerase-1 hyperactivation into a transient energy-producing process. 106
KYNURENINE DISPOSITION IN BLOOD AND BRAIN OF MICE: EFFECTS OF SELECTIVE INHIBITORS OF KYNURENINE HYDROXYLASE AND OF KYNURENINASE 106
Effect of prolonged incubation with copper on endothelium-dependent relaxation in rat isolated aorta. 105
Tryptophan availability selectively limits NO-synthase induction in macrophages. 104
Poly(ADP-ribosyl)ation regulates heat shock factor-1 activity and the heat shock response in murine fibroblasts 103
18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis 103
Expression of indoleamine 2,3-dioxygenase induced by IFN-γ and TNF-α as potential biomarker of prostate cancer progression 103
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity 101
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase. 101
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia. 101
Topical Mannitol Reduces Inflammatory Edema in a Rat Model of Arthritis 100
Cell cycle activation in p21 dependent pathway: An alternative mechanism of organophosphate induced dopaminergic neurodegeneration 99
Hypoxia induces pivotal tumor angiogenesis control factors including p53, vascular endothelial growth factor and the NFkB-dependent inducible nitric oxide synthase and cyclooxygenase-2 98
Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. 97
A snapshot of chemoresistance to PARP inhibitors 97
Brain ischemic preconditioning does not require PARP-1 97
Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide hypothesis' revisited. 94
STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury. 94
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool 92
Mental pain and pain-proneness in migraine subjects: Results from the PAINMIG cohort-study 92
Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. 92
Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid. 91
A deadly chattering among glial cells: the revenge of neglected 91
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases 91
High Mobility Group Box 1 Protein is Released by Neural Cells Upon Different Stresses and Worsens Ischemic Neurodegeneration in vitro and in vivo 91
Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase. 90
Ultra-rapid brain uptake of subcutaneous sumatriptan in the rat: Implication for cluster headache treatment 90
Induction of CD83+ CD14+ non-dendritic antigen-presenting cells by exposure of monocytes to IFN-alpha1 90
Nuclear factor-kappaB as a molecular target for migraine therapy. 89
Dexpramipexole blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models 89
Totale 12.232
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Categoria #
all - tutte 43.598
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.598
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.390 0 0 0 0 0 0 366 334 288 174 171 57
2020/20211.397 135 148 78 111 56 184 47 116 131 208 84 99
2021/20221.032 28 86 71 28 45 67 35 75 53 64 159 321
2022/20232.755 256 483 114 202 187 456 335 137 240 26 83 236
2023/2024900 48 108 164 58 76 81 45 170 20 49 54 27
2024/20255.006 254 688 442 1.008 1.882 730 2 0 0 0 0 0
Totale 15.734