NOCENTINI, ALESSIO
 Distribuzione geografica
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Continente #
NA - Nord America 12.652
AS - Asia 9.179
EU - Europa 8.391
SA - Sud America 1.976
AF - Africa 260
OC - Oceania 101
Continente sconosciuto - Info sul continente non disponibili 1
Totale 32.560
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Nazione #
US - Stati Uniti d'America 12.452
RU - Federazione Russa 3.429
CN - Cina 2.536
SG - Singapore 2.436
IT - Italia 2.342
BR - Brasile 1.587
HK - Hong Kong 1.127
VN - Vietnam 1.088
KR - Corea 887
IE - Irlanda 768
SE - Svezia 349
PL - Polonia 344
FR - Francia 326
IN - India 304
FI - Finlandia 221
BD - Bangladesh 194
ID - Indonesia 159
DE - Germania 154
AR - Argentina 143
GB - Regno Unito 140
CA - Canada 111
AU - Australia 91
EC - Ecuador 85
JP - Giappone 81
JO - Giordania 75
IQ - Iraq 66
NL - Olanda 66
UA - Ucraina 58
CO - Colombia 50
ZA - Sudafrica 45
MX - Messico 44
CI - Costa d'Avorio 43
ES - Italia 43
EG - Egitto 40
NG - Nigeria 39
PY - Paraguay 32
TR - Turchia 32
MA - Marocco 31
PK - Pakistan 29
VE - Venezuela 29
CH - Svizzera 25
UZ - Uzbekistan 23
BE - Belgio 22
BJ - Benin 20
CL - Cile 19
SA - Arabia Saudita 18
PE - Perù 17
PH - Filippine 17
AT - Austria 16
AE - Emirati Arabi Uniti 14
AL - Albania 13
AZ - Azerbaigian 12
TN - Tunisia 12
DZ - Algeria 10
LB - Libano 10
CZ - Repubblica Ceca 9
HN - Honduras 9
LT - Lituania 9
NZ - Nuova Zelanda 8
BH - Bahrain 7
KE - Kenya 7
PT - Portogallo 7
UY - Uruguay 7
CR - Costa Rica 6
GT - Guatemala 6
IR - Iran 6
MY - Malesia 6
NP - Nepal 6
DK - Danimarca 5
GR - Grecia 5
JM - Giamaica 5
LV - Lettonia 5
RO - Romania 5
BO - Bolivia 4
DO - Repubblica Dominicana 4
HR - Croazia 4
HU - Ungheria 4
IL - Israele 4
KZ - Kazakistan 4
PS - Palestinian Territory 4
SN - Senegal 4
TH - Thailandia 4
BB - Barbados 3
BG - Bulgaria 3
KG - Kirghizistan 3
KH - Cambogia 3
KW - Kuwait 3
OM - Oman 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
SV - El Salvador 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
AM - Armenia 2
BA - Bosnia-Erzegovina 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
ET - Etiopia 2
GY - Guiana 2
MD - Moldavia 2
Totale 32.525
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Città #
Santa Clara 2.991
Ashburn 1.993
Singapore 1.885
Hong Kong 926
Seoul 882
Hefei 798
Dublin 761
Fairfield 736
San Jose 521
Milan 475
Ho Chi Minh City 402
Council Bluffs 379
Beijing 343
Woodbridge 341
Warsaw 333
Chandler 326
Moscow 325
Seattle 303
Lawrence 293
Altamura 290
Houston 288
Los Angeles 288
Cambridge 265
The Dalles 241
Lauterbourg 224
Florence 219
Hanoi 218
Wilmington 210
Rome 206
Princeton 176
Ann Arbor 161
Boston 159
Buffalo 155
Dallas 153
Mumbai 142
São Paulo 131
Helsinki 113
Kent 100
Jakarta 93
New York 92
Melbourne 90
Tokyo 71
Lappeenranta 69
Boardman 58
Shanghai 57
Naples 56
San Diego 56
Haiphong 54
Munich 54
Paris 54
Turin 49
Rio de Janeiro 47
Da Nang 45
Medford 45
Clifton 44
Abidjan 43
Bengaluru 43
Bologna 43
West Jordan 43
Abuja 39
Guayaquil 37
Brasília 36
London 36
Chicago 35
Chennai 32
Miano 32
Belo Horizonte 31
Hangzhou 31
Redondo Beach 30
Orem 29
Frankfurt am Main 28
Guangzhou 28
Montreal 28
Toronto 28
Guarulhos 26
Palermo 26
Baghdad 25
Turku 25
Yubileyny 25
Bern 24
San Francisco 24
Biên Hòa 23
Hillsboro 23
Ninh Bình 23
Tianjin 23
Dong Ket 22
Norwalk 22
Amsterdam 21
Atlanta 21
Bari 21
Curitiba 21
Johannesburg 21
Phoenix 21
Quito 21
Tashkent 21
Cotonou 20
Figino 20
Porto Alegre 20
Venice 19
Pune 18
Totale 21.014
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Nome #
β3-adrenoreceptor activity limits apigenin efficacy in ewing sarcoma cells: A dual approach to prevent cell survival 280
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 278
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles. 260
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform 258
A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease 250
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX) 235
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 224
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors 222
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy 219
Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights 212
7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII 205
Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations 203
1,2,3-Benzoxathiazine-2,2-dioxides - effective inhibitors of human carbonic anhydrases 201
Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide derivatives bearing a sulfonamide moiety show single-digit nanomolar-to-subnanomolar inhibition constants against the tumor-associated human carbonic anhydrases IX and XII 201
Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction 200
From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction 200
mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder 199
Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency 197
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats 197
Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies 196
Synthesis and evaluation of carbonic anhydrase inhibitors with carbon monoxide releasing properties for the management of rheumatoid arthritis 196
Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII 192
Aromatic sulfonamides including a sulfonic acid tail: New membrane impermeant carbonic anhydrase inhibitors for targeting selectively the cancer‐associated isoforms 192
Chpater 19 Carbonic Anhydrases from Pathogens: Fungal Carbonic Anhydrases And Their Inhibitors as Potential Antifungal Agents. 185
Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models 184
The role of carbonic anhydrases in extinction of contextual fear memory 181
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 180
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis 179
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action 179
1,5-Diaryl-1,2,4-triazole Ureas as New SLC-0111 Analogues Endowed with Dual Carbonic Anhydrase and VEGFR-2 Inhibitory Activities 178
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases 178
Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR 178
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action 176
Computationally enhanced X-ray diffraction analysis of a gold(III) complex interacting with the human telomeric DNA G-quadruplex. Unravelling non-unique ligand positioning 174
Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes 174
Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide 173
Pyrrolyl and Indolyl alpha-gamma-Diketo Acid Derivatives Acting as Selective Inhibitors of Human Carbonic Anhydrases IX and XII 173
Halogenated isophthalamides and dipicolineamides: The role of the halogen substituents in the anion binding properties 173
Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates 172
Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani 171
Role of carbonic anhydrase in cerebral ischemia and carbonic anhydrase inhibitors as putative protective agents 169
Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives 168
4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition 167
N-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis 167
Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors 167
Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies 166
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights 166
Boron-containing carbonic anhydrases inhibitors 165
Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment 165
Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases 164
Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold 164
Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors 164
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies 162
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies 162
Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii 161
Inhibition of Malassezia globosa carbonic anhydrase with phenols 160
Polypharmacology of epacadostat: A potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII 160
Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents 159
MODELING AND STRUCTURE-BASED APPROACHES IN THE DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF LIGANDS TARGETING THE METALLOENZYMES CARBONIC ANHYDRASES 158
Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII 157
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop 156
Discovery of indolinone-bearing benzenesulfonamides as new dual carbonic anhydrase and VEGFR-2 inhibitors possessing anticancer and pro-apoptotic properties 155
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition 155
Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties 154
Selenols: a new class of carbonic anhydrase inhibitors 154
6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography 152
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases 152
Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors 151
Determination of intracellular protein-ligand binding affinity by competition binding in-cell NMR 150
Synthesis, biological evaluation and computational studies of novel iminothiazolidinone benzenesulfonamides as potent carbonic anhydrase II and IX inhibitors 149
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation 149
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII 148
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells 148
Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors 146
α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors 146
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases 146
Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes 145
Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors 143
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents 143
"a Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII 143
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors 141
1,5-Benzodiazepines as a platform for the design of carbonic anhydrase inhibitors 140
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors 140
Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa 139
Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives 138
Inhibition studies of bacterial α-carbonic anhydrases with phenols 137
Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates 136
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies 136
Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects 135
Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties 135
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy 135
Coumarins effectively inhibit bacterial α-carbonic anhydrases 135
5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery 134
Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity 134
N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition 134
Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae 134
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells 134
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation 133
Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae 132
Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis 131
Totale 16.994
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Categoria #
all - tutte 105.401
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.401
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.014 12 10 56 49 26 57 31 69 245 92 94 273
2022/20232.737 282 730 156 79 176 460 366 87 234 32 79 56
2023/20241.365 26 100 234 65 93 173 60 249 45 200 70 50
2024/20259.472 351 1.178 596 1.302 2.418 1.273 238 372 513 258 418 555
2025/202615.391 1.207 2.053 1.935 2.120 1.166 452 1.334 773 1.013 937 565 1.836
2026/202777 77 0 0 0 0 0 0 0 0 0 0 0
Totale 32.976