MATUCCI, ROSANNA
 Distribuzione geografica
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Continente #
NA - Nord America 4.962
EU - Europa 2.718
AS - Asia 542
AF - Africa 3
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 1
SA - Sud America 1
Totale 8.229
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Nazione #
US - Stati Uniti d'America 4.952
PL - Polonia 904
SE - Svezia 478
IE - Irlanda 450
IT - Italia 311
HK - Hong Kong 194
VN - Vietnam 178
UA - Ucraina 166
DE - Germania 143
FI - Finlandia 98
GB - Regno Unito 85
CN - Cina 82
JO - Giordania 49
TR - Turchia 22
BE - Belgio 20
CH - Svizzera 17
RU - Federazione Russa 14
CA - Canada 9
SG - Singapore 9
NL - Olanda 7
ES - Italia 6
RO - Romania 6
FR - Francia 5
IN - India 5
NO - Norvegia 3
SC - Seychelles 3
AT - Austria 2
EU - Europa 2
IR - Iran 2
AU - Australia 1
BR - Brasile 1
CU - Cuba 1
EE - Estonia 1
KR - Corea 1
LU - Lussemburgo 1
ME - Montenegro 1
Totale 8.229
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Città #
Warsaw 903
Fairfield 817
Chandler 468
Dublin 450
Woodbridge 401
Ashburn 386
Cambridge 326
Seattle 313
Houston 308
Jacksonville 293
Wilmington 268
Ann Arbor 215
Dong Ket 175
Princeton 113
Hong Kong 110
Altamura 94
Lawrence 94
Boston 90
Boardman 74
Buffalo 62
Beijing 45
San Diego 38
Florence 37
Medford 30
Shanghai 23
Falls Church 21
Izmir 21
Brussels 20
Bern 17
West Jordan 16
Norwalk 15
Hillsboro 14
Milan 14
Rome 14
Andover 13
Dearborn 13
Moscow 12
New York 12
Bari 10
Frankfurt Am Main 8
Los Angeles 8
Phoenix 7
Toronto 7
Verona 7
Barcelona 6
Guangzhou 6
Lappeenranta 6
Laurel 6
Philadelphia 6
Washington 6
London 5
Singapore 5
Düsseldorf 4
Tappahannock 4
Auburn Hills 3
Bremen 3
Catanzaro 3
Oslo 3
Redwood City 3
Anghiari 2
Arezzo 2
Ascoli Piceno 2
Augusta 2
Chicago 2
Dallas 2
Gavirate 2
Giugliano in Campania 2
Groningen 2
Hefei 2
Misano Adriatico 2
Montefredane 2
Monza 2
Mumbai 2
Nanjing 2
Napoli 2
Ningbo 2
Parma 2
Southend 2
Southwark 2
Venezia 2
Vienna 2
Acton 1
Amsterdam 1
Bend 1
Berlin 1
Bologna 1
Böblingen 1
Cedar Knolls 1
Cetraro 1
Changsha 1
Cortona 1
Dorno 1
Edinburgh 1
Fabro 1
Falkirk 1
Gottolengo 1
Hanoi 1
Hanover 1
Havana 1
Incisa 1
Totale 6.514
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Nome #
Antisense knockdowns of M1 receptors induces transient anterograde amnesia in mice 234
3-Iodothyroacetic acid (TA1), a by-product of thyroid hormone metabolism, reduces the hypnotic effect of ethanol without interacting at GABA-A receptors. 231
Young human cholinergic neurons respond to physiological regulators and improve cognitive symptoms in an animal model of Alzheimer’s disease 215
3-iodothyronamine (T1AM), a novel antagonist of muscarinic receptors. 210
Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold 204
Synthesis and evaluation as PDE4 inhibitors of pyrimidine-2,4-dione derivatives 199
Late sodium current inhibitors to treat exercise induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium. 180
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 145
1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure–Activity Relationships 138
The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells 131
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 112
1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists. 110
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D 4 Receptor 107
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 106
1,3-oxathiolane muscarinic ligands modified at the cationic head. 106
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 102
Do ethoxy radicals reduce 3H-nitrendipine binding in rat cardiac membranes? 101
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy 101
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 100
PRESYNAPTIC AUTO- AND HETERO-RECEPTORS IN THE CHOLINERGIC REGULATION OF PAIN 95
Ticagrelor-related dyspnea: An underestimated and poorly managed event? 94
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 94
Differential inhibitory effect of taurine on contractile responses to potassium and noradrenaline in rabbit ear artery. 93
Characterization of [3H]substance P binding sites in human skin. 93
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 93
Carbachol dimers as homobivalent modulators of muscarinic receptors 91
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models. 90
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation. 89
ANTINOCICEPTIVE ACTIVITY OF A 3(2H)-PYRIDAZINONE DERIVATE IN MICE 88
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes 88
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 87
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 86
The effect of taurine on excitatory receptor binding in rat hippocampal membranes 86
Effect of taurine on calcium levels and contractility in guinea-pig ventricular strips. 84
Calcium modulatory properties of 2,6-dibutylbenzylamine (B25) in rat isolated vas deferens, cardiac and smooth muscle preparations. 84
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 83
Carbon centered radicals reduce the density of L-type calcium channels in rat cardiac membranes. 83
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments 83
Safety aspects of iodinated contrast media related to their physicochemical properties: a pharmacoepidemiology study in two Tuscany hospitals 82
Does aspirin attenuate the beneficial effect of ACE inhibitors in elderly people with heart failure? 81
Inotropic effect of taurine in guinea-pig ventricular strips. 81
Synthesis and biological evaluation of chiral α-aminoanilides with central antinociceptive activity 81
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism 81
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 80
Calcium channel antagonists discovered by a multidisciplinary approach. 79
L-arginine methylester reduces Ca2+/Cl(-)-dependent L-[3H]glutamate binding and Ca2+-activated neutral protease activity in rat hippocampal membranes. 79
The conformational and property space of acetylcholine bound to muscarinic receptors: an entropy component accounts for the subtype selectivity of acetylcholine 77
Muscarine-like compounds derived from a pyrolysis product of cellulose 76
New insights in the metabolism of Oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone 76
STEREOSELECTIVITY IN CENTRAL ANALGESIC ACTION OF TOCAINIDE AND ITS ANALOGS 75
Influence of oestrogens on muscarinic receptor density and contractile response in the guinea-pig uterus. 75
The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart. 75
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 74
Antagonism/agonism modulation to build novel antihypertensives selectively triggering I1-imidazoline receptor activation 74
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 73
Liver function following hypovolemic hypotension in rats anaesthetized with halothane or enflurane. 72
Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity 72
Constitutive muscarinic receptors are involved in the growth and differentiation of friend erythroleukemia cells. 71
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 71
Protective effect of darodipine, a calcium antagonist, on rat cardiomyocytes against oxygen radical-mediated injury 71
Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide. 71
Cardiac hypoxia and subsequent reoxygenation: sensitivity to L-arginine methylester 69
Synthesis and biological evaluation of 2-mercapto-1,3-benzothiazole derivatives with potential antimicrobial activity 69
Positive inotropic effect of some taurine-related compounds on guinea-pig ventricular strips perfused with low calcium medium. 69
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 67
[3H]-nitrendipine binding in membranes obtained from hypoxic and reoxygenated heart. 67
Electrophysiologic effects of lercanidipine on repolarizing potassium currents. 67
On the presence of H1-receptors in various sections of guinea-pig heart: a correlation between binding and functional studies. 65
Effects of leucine methylester on guinea-pig atria. 63
Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and P-glycoprotein inhibitors. 61
Effect of taurine, L-cysteic and orthanilic acids on cardiac tension. 59
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments. 56
Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica 54
Design, synthesis and binding affinity of acetylcholine carbamoyl analogues 54
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 54
The effect of losartan on expression of beta-adrenoceptors in cardiomyocytes of diabetic and normoglycemic rats 53
Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico 53
synthesis, chiral HPLC separation and pharmacological characterization of muscarinic furan derivatives 52
Synthesis and biological evaluation of a novel series of heterobivalent muscarinic ligands based on xanomeline and 1-[3-(4-butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) 52
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites. 51
A protective effect of taurine on "hypoxic" and "reoxygenated" guinea pig heart. 51
Taurine antagonizes the alpha-adrenergic-positive inotropic effect of phenylephrine. 50
Sintesi e affinità per i recettori colinergici degli stereoisomeri della 1-metil-2-(2-metil-1,3-diossolan-4-il)pirrolidina, della 1-metil-2-(2-metil-1,3-ossatiolan-5-il)pirrolidina e dei loro iodometilati 50
Influence of lithium on the positive inotropic effect of phenylephrine and isoprenaline in guinea-pig heart. 49
Sintesi e valutazione farmacologica di derivati furanici e tetraidrofuranici a potenziale azione muscarinica 45
Highly chiral muscarinic ligands: synthesis and affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides 44
Electropysiologic effects of lercanidipine on repolarizing potassium currents 42
Functional and binding evidence of taurine inhibition of alpha-adrenoceptor effects on guinea-pig ventricle. 41
Beta1 and Beta2 adrenoceptors in human ventricular myocytes: a study of their proportion and signaling pathways. 37
Synthesis and pharmacological characterization of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides 37
2-Hydroxy-1,2,4-benzothiadiazin-1,1-dioxide derivatives as new antagonists of ionotropic glutamate receptors 35
Sovrappeso indotto da farmaci 35
The direct stimulation of gi protein by neuropeptide Y in the rat cardiac left ventricle 35
OXIDATIVE STRESS:CLINICAL IMPLICATIONS IN CARDIAC SURGERY 34
Design, synthesis and preliminary pharmacological evaluation of alkylderivatives of 4-aminopiperidine as N-type calcium channels blockers 34
Unexpected agonistic activity in a series of muscarinic antagonists 33
Design, Synthesis and binding affinity of carbachol dimers as bitopic ligands 33
Molecular modulation of muscarinic antagonists. Synthesis and pharmacological profile of 2,2-diphenyl-2-ethylthioacetic acid and 3,3-diphenyl-3-ethylthiopropionic acid derivatives characterized by a dipeptide spacer 33
Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- And/or 6-Positions of the 1,4-Dioxane Nucleus 32
Cholinergic Receptor Binding Profile of Hypericum perforatum L. and its Active Constituents 28
Totale 8.176
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Categoria #
all - tutte 22.116
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 22.116
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019773 0 0 0 0 0 0 0 0 0 164 324 285
2019/20201.950 151 158 46 162 217 257 213 255 189 104 167 31
2020/20211.362 107 76 108 106 30 160 44 109 104 195 69 254
2021/2022752 28 70 65 19 32 32 39 44 30 31 180 182
2022/20231.934 187 324 95 142 144 350 268 111 209 14 60 30
2023/2024570 28 80 113 37 33 79 16 140 10 34 0 0
Totale 8.322