GUANDALINI, LUCA
 Distribuzione geografica
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Continente #
NA - Nord America 6.852
EU - Europa 4.105
AS - Asia 2.371
SA - Sud America 284
Continente sconosciuto - Info sul continente non disponibili 138
AF - Africa 64
OC - Oceania 38
Totale 13.852
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Nazione #
US - Stati Uniti d'America 6.730
RU - Federazione Russa 1.386
IT - Italia 778
SG - Singapore 672
PL - Polonia 518
CN - Cina 504
HK - Hong Kong 409
SE - Svezia 337
IE - Irlanda 330
VN - Vietnam 307
BR - Brasile 222
KR - Corea 167
DE - Germania 160
FI - Finlandia 141
UA - Ucraina 118
FR - Francia 101
GB - Regno Unito 100
IN - India 90
CA - Canada 84
JP - Giappone 46
AU - Australia 38
JO - Giordania 36
BE - Belgio 28
TR - Turchia 28
AR - Argentina 27
ES - Italia 24
BD - Bangladesh 21
CH - Svizzera 21
IQ - Iraq 20
NL - Olanda 17
MX - Messico 16
CI - Costa d'Avorio 15
ZA - Sudafrica 13
NG - Nigeria 12
RO - Romania 12
ID - Indonesia 11
PK - Pakistan 11
PH - Filippine 8
EC - Ecuador 7
LT - Lituania 7
MA - Marocco 7
VE - Venezuela 7
CL - Cile 6
CZ - Repubblica Ceca 6
AZ - Azerbaigian 5
CO - Colombia 5
JM - Giamaica 5
SA - Arabia Saudita 5
SC - Seychelles 5
UZ - Uzbekistan 5
HU - Ungheria 4
MY - Malesia 4
PE - Perù 4
DZ - Algeria 3
EG - Egitto 3
KZ - Kazakistan 3
LB - Libano 3
PR - Porto Rico 3
PY - Paraguay 3
SK - Slovacchia (Repubblica Slovacca) 3
SN - Senegal 3
AM - Armenia 2
AT - Austria 2
BG - Bulgaria 2
BO - Bolivia 2
CR - Costa Rica 2
CY - Cipro 2
EU - Europa 2
GR - Grecia 2
GT - Guatemala 2
HN - Honduras 2
NP - Nepal 2
PT - Portogallo 2
AE - Emirati Arabi Uniti 1
AG - Antigua e Barbuda 1
AL - Albania 1
BB - Barbados 1
BY - Bielorussia 1
BZ - Belize 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
EE - Estonia 1
IL - Israele 1
KE - Kenya 1
KG - Kirghizistan 1
KH - Cambogia 1
KW - Kuwait 1
LK - Sri Lanka 1
LY - Libia 1
MD - Moldavia 1
MK - Macedonia 1
NI - Nicaragua 1
PS - Palestinian Territory 1
QA - Qatar 1
SV - El Salvador 1
TH - Thailandia 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
UY - Uruguay 1
Totale 13.715
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Città #
Santa Clara 1.566
Ashburn 692
Fairfield 539
Warsaw 515
Singapore 485
Chandler 467
Hong Kong 339
Dublin 329
Woodbridge 227
Cambridge 210
Houston 209
Seattle 205
Jacksonville 176
Ann Arbor 172
Wilmington 168
Seoul 164
San Jose 162
Beijing 160
Milan 142
Council Bluffs 112
The Dalles 100
Los Angeles 96
Buffalo 92
Rome 90
Princeton 87
Boston 77
Ho Chi Minh City 75
Altamura 67
Hanoi 61
Lauterbourg 60
Lawrence 57
Munich 57
Florence 55
Mumbai 53
Dallas 52
Dong Ket 47
New York 47
Tokyo 44
Boardman 42
Melbourne 35
Moscow 35
Shanghai 35
Turku 30
Brussels 28
Helsinki 28
Medford 28
Paris 28
Kent 25
Phoenix 23
Falls Church 22
San Diego 22
São Paulo 22
London 21
Haiphong 20
Hefei 20
Bologna 19
Montreal 19
Toronto 18
Bern 17
Izmir 17
Dearborn 16
Hillsboro 16
Turin 16
Abidjan 15
Barcelona 15
Clifton 15
Naples 15
Redondo Beach 15
Denver 14
Verona 14
Abuja 12
Bari 11
Da Nang 11
Genoa 11
Guangzhou 11
Lappeenranta 11
Norwalk 11
Brescia 10
Brooklyn 10
Columbus 10
Figino 10
Orem 10
San Francisco 10
Venice 10
Palermo 9
Tianjin 9
Chennai 8
Chicago 8
Frankfurt am Main 8
Johannesburg 8
Poplar 7
Washington 7
Amsterdam 6
Ankara 6
Baghdad 6
Basingstoke 6
Belo Horizonte 6
Campinas 6
Curitiba 6
Miano 6
Totale 9.221
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Nome #
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 416
Design, synthesis and binding affinity of new nicotinic ligands 353
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis. 326
DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP) 294
The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells 284
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 266
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 246
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 232
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 231
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents 218
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 217
Central Nicotinic receptors: structure, function, ligands, and therapeutic potential 216
2-PYRROLIDINONE MOIETY IS NOT CRITICAL FOR THE COGNITION ENHANCING ACTIVITY OF PIRACETAM-LIKE DRUGS 215
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 214
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 213
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 209
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 209
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 208
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 208
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 206
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 205
Carbachol dimers as homobivalent modulators of muscarinic receptors 203
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 195
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 192
New phenylalkylamines as isoform selective HCN-Channels blockers 190
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 187
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 185
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 184
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 183
Design of novel nicotinic ligands through 3D database searching 181
SERS detection of benzophenones on viologen functionalized Ag nanoparticles: application to breakfast cereals 180
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 180
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 178
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 175
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 174
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 170
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 167
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 165
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 162
The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model 159
Brevetto # FI2007A000288 riguardante lo sviluppo di Nuovi inibitori delle Deacetilasi Instoniche. Data di deposito: 21 Dicembre, 2007 156
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 155
Design, synthesis and electrophysiological studies of new blockers of HCN channels 153
Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico 153
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 152
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 150
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 150
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 149
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 149
Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators 147
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 146
LEDA TOOL: A POST-PROCESSING ALGORITHM TO RESOLVE ISOBARIC COMPOUDS MIXTURES 145
DM232 and DM235, two potent cognition-enhancers, increase NO levels in rat adipocytes 143
Energy resolved MS/MS experiments for resolution of isobaric compounds: a case of cis/trans isomerism 143
Design, synthesis and preliminary biological evaluation of new 1,4-benzodiazepine-based compounds as histone deacetylase inhibitors and antileukemic agents 142
Metodo per rimuovere un gruppo protettivo di un composto tetrazolico N-protetto 138
Highly chiral muscarinic ligands: synthesis and affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides 137
Resolving mixtures of isobaric compounds using Energy resolved MS/MS experiments and LEDA post-processing algorithm tool 136
Linear deconvolution of LC-MS/MS analysis for resolution of isobaric compounds: a case of cis/trans isomerism 133
Novel hydroxamate histone deacetylase inhibitors 132
Sintesi e valutazione farmacologica di derivati furanici e tetraidrofuranici a potenziale azione muscarinica 130
synthesis, chiral HPLC separation and pharmacological characterization of muscarinic furan derivatives 130
Multidrug resistance inhibitors in plasma samples: the power of LC-energy resolved MS/MS methods for stability investigation 130
Design, Synthesis and binding affinity of carbachol dimers as bitopic ligands 129
Exploratory Chemistry toward the identification of new classes of MDR reverters 129
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 129
Rigid Analogs of DMPP As Probes For The Nicotinic Receptors 128
Design, Synthesis and binding affinity of new ligands for the central nicotinic receptors 126
Resolving mixtures of isobaric compounds using energy resolved MS/MS experiments and the LEDA post processing algorithm tool 124
Synthesis and pharmacological evaluation of new nicotinic ligands carrying a quinoline nucleus 119
Stability in biological fluids by LC-MS/MS analysis of multidrug resistance inhibitors 117
Intermediate compounds for the preparation of angiotensin II antagonists 115
Sintesi e affinità per i recettori colinergici degli stereoisomeri della 1-metil-2-(2-metil-1,3-diossolan-4-il)pirrolidina, della 1-metil-2-(2-metil-1,3-ossatiolan-5-il)pirrolidina e dei loro iodometilati 115
New analogues of the potent nootropic drug DM235: 2-or 3-phenylpiperazines with limited conformational flexibility 114
Design, synthesis and pharmacological evaluation of DMPP analogues to explore the Nicotinic receptor binding site 111
Sintesi chirale e valutazione farmacologica preliminare degli enantiomeri di DM232 e MC68, due azabiciclononanoni modulatori dei processi cognitivi 105
Design, Synthesis and pharmacological evaluation of heterocyclic nicotinic ligands 103
Synthetic approaches to obtain new potential nicotinic agonists with a 5-oxo and 7-oxo-hexahydropyrindine nucleus 102
Phenylalkyltropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands 99
Progettazione, sintesi e valutazione farmacologica preliminare di analoghi strutturali di Sunifiram e Sapunifiram, due potemti agenti nootropi 92
Totale 13.852
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Categoria #
all - tutte 37.257
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.257
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022549 0 87 44 14 17 19 30 32 14 19 125 148
2022/20231.595 134 265 82 137 118 306 195 101 184 5 45 23
2023/2024575 13 69 86 25 31 92 15 162 9 13 30 30
2024/20253.902 125 397 258 567 1.222 633 16 224 146 79 124 111
2025/20263.716 445 513 217 227 448 176 466 136 249 222 71 546
2026/2027226 115 111 0 0 0 0 0 0 0 0 0 0
Totale 13.852