GUANDALINI, LUCA
 Distribuzione geografica
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Continente #
NA - Nord America 6.682
EU - Europa 4.094
AS - Asia 2.365
SA - Sud America 284
AF - Africa 64
OC - Oceania 38
Continente sconosciuto - Info sul continente non disponibili 2
Totale 13.529
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Nazione #
US - Stati Uniti d'America 6.598
RU - Federazione Russa 1.386
IT - Italia 767
SG - Singapore 671
PL - Polonia 518
CN - Cina 502
HK - Hong Kong 407
SE - Svezia 337
IE - Irlanda 330
VN - Vietnam 307
BR - Brasile 222
KR - Corea 167
DE - Germania 160
FI - Finlandia 141
UA - Ucraina 118
FR - Francia 101
GB - Regno Unito 100
IN - India 90
CA - Canada 56
JP - Giappone 46
AU - Australia 38
JO - Giordania 36
BE - Belgio 28
TR - Turchia 28
AR - Argentina 27
ES - Italia 24
BD - Bangladesh 21
CH - Svizzera 21
IQ - Iraq 20
NL - Olanda 17
MX - Messico 16
CI - Costa d'Avorio 15
ZA - Sudafrica 13
NG - Nigeria 12
RO - Romania 12
ID - Indonesia 11
PK - Pakistan 11
PH - Filippine 8
EC - Ecuador 7
LT - Lituania 7
MA - Marocco 7
VE - Venezuela 7
CL - Cile 6
CZ - Repubblica Ceca 6
AZ - Azerbaigian 5
CO - Colombia 5
SA - Arabia Saudita 5
SC - Seychelles 5
UZ - Uzbekistan 5
HU - Ungheria 4
JM - Giamaica 4
MY - Malesia 4
PE - Perù 4
DZ - Algeria 3
EG - Egitto 3
KZ - Kazakistan 3
LB - Libano 3
PY - Paraguay 3
SK - Slovacchia (Repubblica Slovacca) 3
SN - Senegal 3
AM - Armenia 2
AT - Austria 2
BG - Bulgaria 2
BO - Bolivia 2
CY - Cipro 2
EU - Europa 2
GR - Grecia 2
PR - Porto Rico 2
PT - Portogallo 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
BY - Bielorussia 1
BZ - Belize 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
EE - Estonia 1
HN - Honduras 1
IL - Israele 1
KE - Kenya 1
KG - Kirghizistan 1
KH - Cambogia 1
KW - Kuwait 1
LK - Sri Lanka 1
LY - Libia 1
MD - Moldavia 1
MK - Macedonia 1
NI - Nicaragua 1
NP - Nepal 1
PS - Palestinian Territory 1
QA - Qatar 1
SV - El Salvador 1
TH - Thailandia 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
UY - Uruguay 1
Totale 13.529
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Città #
Santa Clara 1.559
Ashburn 690
Fairfield 539
Warsaw 515
Singapore 485
Chandler 467
Hong Kong 337
Dublin 329
Woodbridge 227
Cambridge 209
Houston 209
Seattle 205
Jacksonville 176
Ann Arbor 172
Wilmington 168
Seoul 164
Beijing 159
San Jose 159
Milan 142
The Dalles 100
Los Angeles 96
Buffalo 92
Rome 88
Princeton 87
Boston 77
Ho Chi Minh City 75
Altamura 67
Hanoi 61
Lauterbourg 60
Lawrence 57
Munich 57
Florence 55
Mumbai 53
Dallas 52
Dong Ket 47
New York 47
Tokyo 44
Boardman 42
Council Bluffs 37
Melbourne 35
Moscow 35
Shanghai 35
Turku 30
Brussels 28
Helsinki 28
Medford 28
Paris 28
Kent 25
Falls Church 22
São Paulo 22
San Diego 21
Haiphong 20
Hefei 20
London 20
Phoenix 20
Bologna 19
Bern 17
Izmir 17
Toronto 17
Dearborn 16
Hillsboro 16
Abidjan 15
Barcelona 15
Clifton 15
Montreal 15
Redondo Beach 15
Turin 15
Denver 14
Naples 14
Verona 14
Abuja 12
Bari 11
Da Nang 11
Guangzhou 11
Lappeenranta 11
Norwalk 11
Brescia 10
Brooklyn 10
Figino 10
Genoa 10
Orem 10
San Francisco 10
Venice 10
Palermo 9
Tianjin 9
Chennai 8
Frankfurt am Main 8
Johannesburg 8
Chicago 7
Poplar 7
Washington 7
Amsterdam 6
Ankara 6
Baghdad 6
Basingstoke 6
Belo Horizonte 6
Campinas 6
Curitiba 6
Miano 6
Redwood City 6
Totale 9.110
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Nome #
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 408
Design, synthesis and binding affinity of new nicotinic ligands 352
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis. 324
DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP) 293
The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells 281
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 260
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 245
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 230
(1,3-Dioxolane)- and (1,3-oxathiolane)-2-pyrrolidines: molecular hybrids with potential anti-Alzheimer activity 226
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents 216
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 213
Central Nicotinic receptors: structure, function, ligands, and therapeutic potential 213
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 212
Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism 212
2-PYRROLIDINONE MOIETY IS NOT CRITICAL FOR THE COGNITION ENHANCING ACTIVITY OF PIRACETAM-LIKE DRUGS 207
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 207
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 207
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 207
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 204
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 204
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 203
Carbachol dimers as homobivalent modulators of muscarinic receptors 197
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 194
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 190
New phenylalkylamines as isoform selective HCN-Channels blockers 189
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 185
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 182
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 182
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 182
Design of novel nicotinic ligands through 3D database searching 178
SERS detection of benzophenones on viologen functionalized Ag nanoparticles: application to breakfast cereals 178
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 178
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 176
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 174
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 171
The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors 168
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 163
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 163
The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model 158
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 156
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 154
Brevetto # FI2007A000288 riguardante lo sviluppo di Nuovi inibitori delle Deacetilasi Instoniche. Data di deposito: 21 Dicembre, 2007 153
Design, synthesis and electrophysiological studies of new blockers of HCN channels 152
Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico 152
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 151
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 148
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 148
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 147
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 147
Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators 144
LEDA TOOL: A POST-PROCESSING ALGORITHM TO RESOLVE ISOBARIC COMPOUDS MIXTURES 144
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 143
DM232 and DM235, two potent cognition-enhancers, increase NO levels in rat adipocytes 142
Energy resolved MS/MS experiments for resolution of isobaric compounds: a case of cis/trans isomerism 141
Design, synthesis and preliminary biological evaluation of new 1,4-benzodiazepine-based compounds as histone deacetylase inhibitors and antileukemic agents 138
Metodo per rimuovere un gruppo protettivo di un composto tetrazolico N-protetto 136
Highly chiral muscarinic ligands: synthesis and affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-oxathiolane-5-yl)pyrrolidine 3-sulfoxides and their methyl iodides 135
Resolving mixtures of isobaric compounds using Energy resolved MS/MS experiments and LEDA post-processing algorithm tool 134
Linear deconvolution of LC-MS/MS analysis for resolution of isobaric compounds: a case of cis/trans isomerism 132
Novel hydroxamate histone deacetylase inhibitors 129
Multidrug resistance inhibitors in plasma samples: the power of LC-energy resolved MS/MS methods for stability investigation 129
synthesis, chiral HPLC separation and pharmacological characterization of muscarinic furan derivatives 128
Sintesi e valutazione farmacologica di derivati furanici e tetraidrofuranici a potenziale azione muscarinica 127
Design, Synthesis and binding affinity of carbachol dimers as bitopic ligands 127
Exploratory Chemistry toward the identification of new classes of MDR reverters 127
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 127
Rigid Analogs of DMPP As Probes For The Nicotinic Receptors 126
Design, Synthesis and binding affinity of new ligands for the central nicotinic receptors 123
Resolving mixtures of isobaric compounds using energy resolved MS/MS experiments and the LEDA post processing algorithm tool 122
Synthesis and pharmacological evaluation of new nicotinic ligands carrying a quinoline nucleus 118
Stability in biological fluids by LC-MS/MS analysis of multidrug resistance inhibitors 115
Sintesi e affinità per i recettori colinergici degli stereoisomeri della 1-metil-2-(2-metil-1,3-diossolan-4-il)pirrolidina, della 1-metil-2-(2-metil-1,3-ossatiolan-5-il)pirrolidina e dei loro iodometilati 114
Intermediate compounds for the preparation of angiotensin II antagonists 112
New analogues of the potent nootropic drug DM235: 2-or 3-phenylpiperazines with limited conformational flexibility 112
Design, synthesis and pharmacological evaluation of DMPP analogues to explore the Nicotinic receptor binding site 109
Sintesi chirale e valutazione farmacologica preliminare degli enantiomeri di DM232 e MC68, due azabiciclononanoni modulatori dei processi cognitivi 104
Design, Synthesis and pharmacological evaluation of heterocyclic nicotinic ligands 101
Synthetic approaches to obtain new potential nicotinic agonists with a 5-oxo and 7-oxo-hexahydropyrindine nucleus 99
Phenylalkyltropanyl esters and ethers of phenoxypropionic acid as novel sigma receptor ligands 98
Progettazione, sintesi e valutazione farmacologica preliminare di analoghi strutturali di Sunifiram e Sapunifiram, due potemti agenti nootropi 89
Totale 13.665
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Categoria #
all - tutte 36.136
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.136
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022569 20 87 44 14 17 19 30 32 14 19 125 148
2022/20231.595 134 265 82 137 118 306 195 101 184 5 45 23
2023/2024575 13 69 86 25 31 92 15 162 9 13 30 30
2024/20253.902 125 397 258 567 1.222 633 16 224 146 79 124 111
2025/20263.716 445 513 217 227 448 176 466 136 249 222 71 546
2026/202739 39 0 0 0 0 0 0 0 0 0 0 0
Totale 13.665