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Durvalumab Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Biliary Tract Cancer: a Real-World Retrospective, Multicenter Study

Background The TOPAZ-1 phase III trial reported a survival benefit with the anti-programmed cell death ligand 1 (anti-PD-L1) durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer (BTC). Objective The present study investigated for the first time the impact on survival of adding durvalumab to cisplatin/gemcitabine compared with cisplatin/gemcitabine in a real-world setting. Patients and Methods The analyzed population included patients with unr...

A randomized phase II trial of Captem or Folfiri as second-line therapy in neuroendocrine carcinomas

Background: Neuroendocrine Carcinomas (NECs) prognosis is poor.No standard second-line therapy is currently recognized after failure of platinum-based first-line treatment. FOLFIRI and CAPTEM regimens have shown promising activity in preliminary studies. We aimed to evaluate these regimens in metastatic NEC patients. Methods: This is an open-label, multicenter, randomized non-comparative phase II trial to evaluate the activity and safety of FOLFIRI or CAPTEM in metastatic NEC patients. Primar...

Delineation of gastrointestinal tumors biopsies using a fluorescence lifetime imaging optical fiber probe

Autofluorescence spectroscopy has emerged in recent years as a powerful tool to report label-free contrast between normal and diseased tissues, both in vivo and ex-vivo. We report the application of an instrument employing an optical fiber probe and capable of performing real-time autofluorescence lifetime imaging at a macroscopic scale, under bright background conditions. We validate and demonstrate the practicality of this technology to discriminate healthy against neoplastic tissue in fres...

Pathological complete response achieved with FLOT chemotherapy in two patients with MSI-H esophagogastric junction and gastric adenocarcinoma

: Globally, more than 1 million new cases of gastric cancer were estimated in 2020, ranking fourth in cancer mortality. Currently although in resectable gastric cancer and esophagogastric junction (EGJ) adenocarcinoma a perioperative triplet chemotherapy regimen including a fluoropyrimidine, a platinum compound and docetaxel (FLOT) demonstrated a better overall survival, the survival rate is still very low, and a massive effort is still required to improve clinical prognosis. High microsatell...

Impact of metformin, statin, aspirin and insulin on the prognosis of uHCC patients receiving first line Lenvatinib or Atezolizumab plus Bevacizumab

: Recently, in Hepatocellular carcinoma (HCC) setting, the use of metformin has been associated to a trend toward worse response rate, overall survival and progression free survival in patients who received immunotherapy. The study population included individuals from both Eastern and Western regions with a confirmed diagnosis of HCC and receiving first line treatment with Atezolizumab plus bevacizumab or Lenvatinib. Univariate and multivariate analyses were performed by Cox proportional. For...

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Tipologia
  • 1 - Contributo su rivista139612
  • 2 - Contributo in volume44862
  • 4 - Contributo in atti di convegno (Proceedings)37756
  • 3 - Libro9324
  • 7 - Curatela5002
  • 5 - Altro4380
  • 8 - Tesi di dottorato3871
  • 6 - Brevetti e copyright471
Autore
  • SUPURAN, CLAUDIU TRANDAFIR1939
  • D'ALESSANDRO, RAFFAELLO1729
  • FOCARDI, ETTORE1604
  • CIULLI, VITALIANO1518
  • LENZI, PIERGIULIO1259
  • GENSINI, GIAN FRANCO1036
  • LATINO, GIUSEPPE1024
  • PETRAGLIA, FELICE997
  • MATUCCI CERINIC, MARCO943
  • BRANDI, MARIA LUISA869
Data di pubblicazione
  • In corso di stampa623
  • 2020 - 202538764
  • 2010 - 201991681
  • 2000 - 200968742
  • 1990 - 199930097
  • 1980 - 198911919
  • 1970 - 19793151
  • 1960 - 1969287
  • 1955 - 19599
Editore
  • Firenze University Press1939
  • IEEE1673
  • Springer1351
  • Franco Angeli924
  • Il Mulino730
  • Giappichelli725
  • ETS724
  • Giuffrè614
  • Alinea607
  • Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598575
Rivista
  • WWW.DRAMMATURGIA.IT1222
  • PHYSICS LETTERS. SECTION B945
  • PHYSICAL REVIEW LETTERS728
  • FIRENZE ARCHITETTURA655
  • PLOS ONE484
  • SCIENTIFIC REPORTS442
  • JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY416
  • NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT401
  • JOURNAL OF HIGH ENERGY PHYSICS396
  • INORGANIC CHEMISTRY383
Serie
  • LECTURE NOTES IN COMPUTER SCIENCE165
  • PROCEEDINGS OF SPIE, THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING112
  • LECTURE NOTES IN ARTIFICIAL INTELLIGENCE79
  • IFMBE PROCEEDINGS63
  • LECTURE NOTES IN MECHANICAL ENGINEERING49
  • CEUR WORKSHOP PROCEEDINGS42
  • LECTURE NOTES IN ELECTRICAL ENGINEERING41
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  • STUDI E SAGGI32
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  • Humans5645
  • Male2582
  • Female2499
  • Italy1631
  • Middle Aged1582
  • Aged1459
  • Adult1343
  • Firenze1067
  • Italia990
  • Animals958
Lingua
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  • ita25140
  • fre913
  • spa498
  • ger451
  • por139
  • lat92
  • rus66
  • chi41
  • enm38
Accesso al fulltext
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  • reserved52785
  • open41578
  • partially open1439
  • embargoed231
  • mixed6