MANETTI, DINA
 Distribuzione geografica
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Continente #
NA - Nord America 12.483
EU - Europa 8.025
AS - Asia 5.503
SA - Sud America 658
Continente sconosciuto - Info sul continente non disponibili 261
AF - Africa 166
OC - Oceania 94
Totale 27.190
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Nazione #
US - Stati Uniti d'America 12.204
RU - Federazione Russa 2.558
IT - Italia 1.629
SG - Singapore 1.570
CN - Cina 1.267
PL - Polonia 1.218
HK - Hong Kong 849
IE - Irlanda 691
VN - Vietnam 605
SE - Svezia 573
BR - Brasile 522
KR - Corea 491
DE - Germania 296
FI - Finlandia 246
FR - Francia 232
CA - Canada 176
UA - Ucraina 174
IN - India 165
GB - Regno Unito 157
JP - Giappone 116
BD - Bangladesh 96
AU - Australia 92
TR - Turchia 55
NL - Olanda 52
ID - Indonesia 49
JO - Giordania 48
AR - Argentina 46
MX - Messico 45
CH - Svizzera 41
ES - Italia 41
IQ - Iraq 40
CI - Costa d'Avorio 36
NG - Nigeria 35
BE - Belgio 34
ZA - Sudafrica 28
PK - Pakistan 21
CO - Colombia 20
EC - Ecuador 17
AT - Austria 16
UZ - Uzbekistan 16
CL - Cile 15
PH - Filippine 15
VE - Venezuela 14
RO - Romania 13
JM - Giamaica 12
MA - Marocco 11
PY - Paraguay 10
TN - Tunisia 10
AZ - Azerbaigian 9
LT - Lituania 9
MY - Malesia 9
CR - Costa Rica 8
KE - Kenya 8
LB - Libano 8
NP - Nepal 8
PE - Perù 8
SA - Arabia Saudita 8
SC - Seychelles 8
TW - Taiwan 8
DZ - Algeria 7
EG - Egitto 7
KZ - Kazakistan 7
TH - Thailandia 7
CZ - Repubblica Ceca 6
GT - Guatemala 6
HU - Ungheria 6
TT - Trinidad e Tobago 6
AL - Albania 5
BJ - Benin 5
IL - Israele 5
NI - Nicaragua 5
BH - Bahrain 4
MO - Macao, regione amministrativa speciale della Cina 4
PT - Portogallo 4
AE - Emirati Arabi Uniti 3
AM - Armenia 3
BG - Bulgaria 3
CY - Cipro 3
DK - Danimarca 3
EU - Europa 3
GE - Georgia 3
HN - Honduras 3
KG - Kirghizistan 3
PR - Porto Rico 3
PS - Palestinian Territory 3
SK - Slovacchia (Repubblica Slovacca) 3
SN - Senegal 3
UY - Uruguay 3
BB - Barbados 2
BO - Bolivia 2
BS - Bahamas 2
BY - Bielorussia 2
ET - Etiopia 2
GR - Grecia 2
IR - Iran 2
LV - Lettonia 2
MD - Moldavia 2
MU - Mauritius 2
NZ - Nuova Zelanda 2
PA - Panama 2
Totale 26.908
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Città #
Santa Clara 2.707
Ashburn 1.526
Warsaw 1.211
Singapore 1.108
Fairfield 796
Chandler 717
Hong Kong 710
Dublin 690
Seoul 439
San Jose 375
Woodbridge 360
Cambridge 358
Milan 322
Seattle 319
Houston 299
Jacksonville 290
Council Bluffs 278
Beijing 273
Wilmington 272
Hefei 227
Ann Arbor 207
Los Angeles 186
The Dalles 173
Buffalo 166
Ho Chi Minh City 165
Princeton 160
Rome 151
Boston 149
Florence 142
Lauterbourg 133
Hanoi 127
Altamura 126
Dallas 110
Tokyo 110
Lawrence 104
Mumbai 96
Dong Ket 94
Boardman 93
Melbourne 86
Munich 85
Moscow 81
New York 81
Shanghai 59
Helsinki 54
Kent 52
Paris 49
San Diego 49
Medford 47
São Paulo 44
Turku 43
Phoenix 41
Naples 39
Seongnam 38
Turin 38
Montreal 37
Abidjan 36
Bologna 36
Bern 35
Frankfurt am Main 33
Redondo Beach 33
Abuja 32
Brussels 31
Falls Church 31
Guangzhou 31
Jakarta 31
Orem 31
Toronto 30
London 29
Chicago 28
Norwalk 28
Clifton 26
Haiphong 26
Hillsboro 26
Izmir 25
Washington 24
Brooklyn 23
Bari 22
Lappeenranta 20
Figino 19
Verona 19
Andover 18
Denver 18
Nuremberg 18
San Francisco 18
Tianjin 18
Chennai 17
Dearborn 17
Genoa 17
Palermo 17
Amsterdam 16
Rio de Janeiro 16
Columbus 15
Da Nang 15
Johannesburg 15
Venice 15
Baghdad 14
Tashkent 14
Barcelona 13
Bengaluru 13
Brescia 13
Totale 17.714
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Nome #
Antinociceptive property of the nicotinic agonist AG4 in rodents 530
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 428
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 415
The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats 414
Antinociceptive profile of SM21: a novel analgesic with a presynaptic cholinergic mechanism of action 341
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers 315
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 308
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 284
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 275
Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the ACh releaser PG9 268
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 263
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 251
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 250
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 246
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 238
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 236
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 231
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 223
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 219
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). 216
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 215
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 214
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 213
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 211
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 209
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 209
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 208
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 208
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 208
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 206
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 205
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 205
Carbachol dimers as homobivalent modulators of muscarinic receptors 203
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators 202
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 200
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 195
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 195
(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation 195
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 193
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 192
New phenylalkylamines as isoform selective HCN-Channels blockers 190
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 188
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 187
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 185
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 184
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 184
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 184
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 183
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 183
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 182
Design of novel nicotinic ligands through 3D database searching 181
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 180
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 179
"Synthesis and binding properties of photoactivable Biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein" 179
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 179
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 178
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 177
Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors 176
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 175
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 175
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 174
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 174
The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats 173
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission 171
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation 171
The piperazine scaffold for novel drug discovery efforts: the evidence to date 168
Synthetic approaches to piperazine-containing drugs approved by FDA in the period of 2011–2023 167
Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold 167
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 166
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 165
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 165
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 164
Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex 162
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 162
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 161
Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica 160
A recombinant transductor-effector system: in vitro study of G inhibitor protein (G-alfa-i1)direct activators 158
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 157
HCN Channels Modulators: The Need for Selectivity 155
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 155
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 155
Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4-Substituted Quinazoline Derivatives 155
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neruopathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation 154
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity 154
Design, synthesis and electrophysiological studies of new blockers of HCN channels 153
Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico 153
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 152
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 152
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 150
Inhibition of P-glycoprotein-mediated multidrug resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: structure-activity relationships 150
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 150
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers 149
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 149
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 149
Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat 148
Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators 147
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs 146
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 146
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 144
DM232 and DM235, two potent cognition-enhancers, increase NO levels in rat adipocytes 143
Totale 19.960
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Categoria #
all - tutte 74.555
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 74.555
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022993 0 142 80 33 25 38 55 54 28 35 207 296
2022/20232.729 251 440 129 224 174 538 369 169 279 12 87 57
2023/20241.364 41 125 185 71 83 216 30 462 21 36 46 48
2024/20257.469 257 742 476 1.018 2.128 1.170 130 451 320 173 283 321
2025/20268.486 871 1.136 686 590 946 364 992 404 547 520 246 1.184
2026/2027579 366 213 0 0 0 0 0 0 0 0 0 0
Totale 27.190