MANETTI, DINA
 Distribuzione geografica
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Continente #
NA - Nord America 13.771
EU - Europa 8.056
AS - Asia 5.525
SA - Sud America 678
Continente sconosciuto - Info sul continente non disponibili 262
AF - Africa 166
OC - Oceania 94
Totale 28.552
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Nazione #
US - Stati Uniti d'America 13.456
RU - Federazione Russa 2.558
IT - Italia 1.647
SG - Singapore 1.574
CN - Cina 1.267
PL - Polonia 1.218
HK - Hong Kong 849
IE - Irlanda 692
VN - Vietnam 608
SE - Svezia 573
BR - Brasile 529
KR - Corea 491
DE - Germania 297
FI - Finlandia 246
FR - Francia 234
CA - Canada 196
UA - Ucraina 174
IN - India 165
GB - Regno Unito 164
JP - Giappone 117
BD - Bangladesh 97
AU - Australia 92
TR - Turchia 57
ID - Indonesia 54
NL - Olanda 52
JO - Giordania 48
MX - Messico 47
AR - Argentina 46
CH - Svizzera 41
ES - Italia 41
IQ - Iraq 40
CI - Costa d'Avorio 36
BE - Belgio 35
NG - Nigeria 35
ZA - Sudafrica 28
CO - Colombia 23
PK - Pakistan 22
VE - Venezuela 20
EC - Ecuador 19
AT - Austria 16
CL - Cile 16
JM - Giamaica 16
PH - Filippine 16
UZ - Uzbekistan 16
RO - Romania 13
MY - Malesia 12
MA - Marocco 11
CR - Costa Rica 10
PY - Paraguay 10
TN - Tunisia 10
TT - Trinidad e Tobago 10
AZ - Azerbaigian 9
LT - Lituania 9
TW - Taiwan 9
GT - Guatemala 8
KE - Kenya 8
LB - Libano 8
NP - Nepal 8
PE - Perù 8
SA - Arabia Saudita 8
SC - Seychelles 8
DZ - Algeria 7
EG - Egitto 7
KZ - Kazakistan 7
TH - Thailandia 7
CZ - Repubblica Ceca 6
HU - Ungheria 6
AL - Albania 5
BJ - Benin 5
IL - Israele 5
NI - Nicaragua 5
BH - Bahrain 4
MO - Macao, regione amministrativa speciale della Cina 4
PR - Porto Rico 4
PT - Portogallo 4
AE - Emirati Arabi Uniti 3
AM - Armenia 3
BG - Bulgaria 3
BO - Bolivia 3
CY - Cipro 3
DK - Danimarca 3
EU - Europa 3
GE - Georgia 3
HN - Honduras 3
KG - Kirghizistan 3
PS - Palestinian Territory 3
SK - Slovacchia (Repubblica Slovacca) 3
SN - Senegal 3
UY - Uruguay 3
BB - Barbados 2
BS - Bahamas 2
BY - Bielorussia 2
ET - Etiopia 2
GR - Grecia 2
IR - Iran 2
LV - Lettonia 2
MD - Moldavia 2
MU - Mauritius 2
NZ - Nuova Zelanda 2
PA - Panama 2
Totale 28.267
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Città #
Santa Clara 2.715
Ashburn 1.794
Warsaw 1.211
Singapore 1.110
Fairfield 796
Chandler 717
Hong Kong 710
Dublin 690
San Jose 546
Seoul 439
Woodbridge 360
Cambridge 358
Milan 325
Seattle 323
Houston 306
Jacksonville 294
Council Bluffs 289
Beijing 273
Wilmington 272
Hefei 227
Ann Arbor 207
Los Angeles 199
The Dalles 179
Buffalo 172
Ho Chi Minh City 167
Princeton 161
Rome 154
Boston 151
Florence 146
Lauterbourg 133
Hanoi 127
Altamura 126
Dallas 115
Tokyo 111
Lawrence 104
Phoenix 102
Mumbai 96
Chicago 95
Dong Ket 94
Boardman 93
New York 93
Melbourne 86
Munich 86
Moscow 81
Shanghai 59
Washington 55
Helsinki 54
Kent 52
San Diego 50
Paris 49
Medford 47
São Paulo 44
Turku 43
Naples 39
Turin 39
Montreal 38
Seongnam 38
Abidjan 36
Bologna 36
Bern 35
Toronto 35
Frankfurt am Main 33
Redondo Beach 33
Abuja 32
Brussels 31
Falls Church 31
Guangzhou 31
Jakarta 31
Orem 31
London 30
Norwalk 29
Clifton 26
Haiphong 26
Hillsboro 26
Brooklyn 25
Izmir 25
Denver 24
Atlanta 23
Bari 22
San Francisco 21
Lappeenranta 20
Figino 19
Verona 19
Andover 18
Genoa 18
Nuremberg 18
Philadelphia 18
Tianjin 18
Chennai 17
Columbus 17
Dearborn 17
Palermo 17
Amsterdam 16
Rio de Janeiro 16
Da Nang 15
Johannesburg 15
Venice 15
Baghdad 14
Brasília 14
Tashkent 14
Totale 18.447
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Nome #
Antinociceptive property of the nicotinic agonist AG4 in rodents 537
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 445
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 432
The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats 427
Antinociceptive profile of SM21: a novel analgesic with a presynaptic cholinergic mechanism of action 349
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers 321
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 319
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 296
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 283
Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the ACh releaser PG9 272
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 271
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 261
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 257
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 253
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 249
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 244
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 240
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 235
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 231
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 229
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). 221
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 221
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 219
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 219
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 218
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 216
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 216
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 214
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 213
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 213
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 212
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 211
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 211
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 208
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators 208
Carbachol dimers as homobivalent modulators of muscarinic receptors 208
(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation 205
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 204
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 204
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 200
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 196
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 196
New phenylalkylamines as isoform selective HCN-Channels blockers 195
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 194
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 194
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 192
Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors 190
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 190
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 189
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 188
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 188
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 188
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 187
Design of novel nicotinic ligands through 3D database searching 186
"Synthesis and binding properties of photoactivable Biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein" 186
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 185
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 185
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission 184
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 183
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 182
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation 181
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 181
The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats 180
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 180
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 180
Design, synthesis and electrophysiological studies of new blockers of HCN channels 179
Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex 178
Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold 176
Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico 175
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 175
The piperazine scaffold for novel drug discovery efforts: the evidence to date 174
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neruopathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation 173
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 171
Synthetic approaches to piperazine-containing drugs approved by FDA in the period of 2011–2023 170
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 170
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 169
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 168
Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica 168
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 167
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 165
New multidrug resistance (MDR) agents endowed with good potency and efficacy 163
A recombinant transductor-effector system: in vitro study of G inhibitor protein (G-alfa-i1)direct activators 162
HCN Channels Modulators: The Need for Selectivity 161
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 161
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 160
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 160
Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4-Substituted Quinazoline Derivatives 159
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 158
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 158
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 158
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers 157
Inhibition of P-glycoprotein-mediated multidrug resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: structure-activity relationships 157
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity 157
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 157
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 157
Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators 156
Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat 155
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 155
Sintesi e valutazione farmacologica di derivati furanici e tetraidrofuranici a potenziale azione muscarinica 153
New N-alkanol-N-cyclohexanolamine aryl ester derivatives as reverting agents of Multidrug Resistance (MDR) 153
Totale 20.807
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Categoria #
all - tutte 78.253
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 78.253
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022771 0 0 0 33 25 38 55 54 28 35 207 296
2022/20232.729 251 440 129 224 174 538 369 169 279 12 87 57
2023/20241.364 41 125 185 71 83 216 30 462 21 36 46 48
2024/20257.469 257 742 476 1.018 2.128 1.170 130 451 320 173 283 321
2025/20268.486 871 1.136 686 590 946 364 992 404 547 520 246 1.184
2026/20271.941 366 275 982 318 0 0 0 0 0 0 0 0
Totale 28.552