MANETTI, DINA
 Distribuzione geografica
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Continente #
NA - Nord America 11.977
EU - Europa 7.969
AS - Asia 5.489
SA - Sud America 656
AF - Africa 166
OC - Oceania 94
Continente sconosciuto - Info sul continente non disponibili 4
Totale 26.355
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Nazione #
US - Stati Uniti d'America 11.805
RU - Federazione Russa 2.558
IT - Italia 1.582
SG - Singapore 1.567
CN - Cina 1.265
PL - Polonia 1.217
HK - Hong Kong 847
IE - Irlanda 690
VN - Vietnam 605
SE - Svezia 573
BR - Brasile 522
KR - Corea 491
DE - Germania 296
FI - Finlandia 246
FR - Francia 232
UA - Ucraina 174
IN - India 165
GB - Regno Unito 155
JP - Giappone 116
CA - Canada 98
BD - Bangladesh 93
AU - Australia 92
TR - Turchia 55
NL - Olanda 51
ID - Indonesia 49
JO - Giordania 48
AR - Argentina 46
MX - Messico 45
CH - Svizzera 41
IQ - Iraq 40
ES - Italia 39
CI - Costa d'Avorio 36
NG - Nigeria 35
BE - Belgio 33
ZA - Sudafrica 28
PK - Pakistan 20
CO - Colombia 19
EC - Ecuador 17
AT - Austria 16
UZ - Uzbekistan 16
CL - Cile 15
PH - Filippine 15
VE - Venezuela 14
RO - Romania 13
MA - Marocco 11
PY - Paraguay 10
TN - Tunisia 10
AZ - Azerbaigian 9
LT - Lituania 9
JM - Giamaica 8
KE - Kenya 8
LB - Libano 8
PE - Perù 8
SA - Arabia Saudita 8
SC - Seychelles 8
TW - Taiwan 8
DZ - Algeria 7
EG - Egitto 7
KZ - Kazakistan 7
MY - Malesia 7
NP - Nepal 7
TH - Thailandia 7
CR - Costa Rica 6
CZ - Repubblica Ceca 6
AL - Albania 5
BJ - Benin 5
HU - Ungheria 5
IL - Israele 5
BH - Bahrain 4
MO - Macao, regione amministrativa speciale della Cina 4
PT - Portogallo 4
AE - Emirati Arabi Uniti 3
AM - Armenia 3
BG - Bulgaria 3
CY - Cipro 3
DK - Danimarca 3
EU - Europa 3
GE - Georgia 3
KG - Kirghizistan 3
NI - Nicaragua 3
PS - Palestinian Territory 3
SK - Slovacchia (Repubblica Slovacca) 3
SN - Senegal 3
UY - Uruguay 3
BO - Bolivia 2
BY - Bielorussia 2
ET - Etiopia 2
GR - Grecia 2
IR - Iran 2
LV - Lettonia 2
MD - Moldavia 2
MU - Mauritius 2
NZ - Nuova Zelanda 2
PA - Panama 2
SI - Slovenia 2
TT - Trinidad e Tobago 2
A1 - Anonimo 1
AO - Angola 1
BS - Bahamas 1
BZ - Belize 1
Totale 26.338
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Città #
Santa Clara 2.699
Ashburn 1.479
Warsaw 1.211
Singapore 1.107
Fairfield 796
Chandler 717
Hong Kong 708
Dublin 689
Seoul 439
San Jose 365
Woodbridge 360
Cambridge 357
Milan 317
Seattle 317
Houston 298
Jacksonville 290
Beijing 273
Wilmington 272
Hefei 227
Ann Arbor 206
Los Angeles 176
The Dalles 173
Buffalo 166
Ho Chi Minh City 165
Princeton 160
Boston 145
Council Bluffs 144
Florence 142
Rome 141
Lauterbourg 133
Hanoi 127
Altamura 126
Tokyo 110
Lawrence 104
Dallas 103
Mumbai 96
Dong Ket 94
Boardman 93
Melbourne 86
Munich 85
Moscow 81
New York 75
Shanghai 59
Helsinki 54
Kent 52
Paris 49
Medford 47
San Diego 47
São Paulo 44
Turku 43
Phoenix 38
Seongnam 38
Turin 37
Abidjan 36
Bologna 36
Naples 36
Bern 35
Frankfurt am Main 33
Redondo Beach 33
Abuja 32
Falls Church 31
Guangzhou 31
Jakarta 31
Brussels 30
Norwalk 28
Haiphong 26
Montreal 26
Orem 26
Clifton 25
Hillsboro 25
Izmir 25
London 25
Washington 23
Bari 22
Brooklyn 21
Chicago 21
Toronto 21
Lappeenranta 20
Verona 19
Andover 18
Figino 18
Nuremberg 18
Tianjin 18
Chennai 17
Dearborn 17
Palermo 17
Amsterdam 16
Denver 16
Genoa 16
Rio de Janeiro 16
Da Nang 15
Johannesburg 15
Baghdad 14
San Francisco 14
Tashkent 14
Venice 14
Barcelona 13
Bengaluru 13
Brasília 12
Brescia 12
Totale 17.400
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Nome #
Antinociceptive property of the nicotinic agonist AG4 in rodents 526
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 421
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 408
The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats 407
Antinociceptive profile of SM21: a novel analgesic with a presynaptic cholinergic mechanism of action 336
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers 310
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 306
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 277
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 273
Memory facilitation and stimulation of endogenous nerve growth factor synthesis by the ACh releaser PG9 261
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND AFFINITY PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIO-ACETIC ACID ESTERS DESIGNED TO PROBE THE BINDING SITE CAVITY 260
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 245
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 244
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 236
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 232
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 230
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 220
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 214
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). 213
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 212
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 211
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 211
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 208
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 207
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 207
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 205
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 203
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 203
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 202
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 202
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 201
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators 200
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 197
Carbachol dimers as homobivalent modulators of muscarinic receptors 197
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 193
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 192
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 189
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 189
(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation 189
New phenylalkylamines as isoform selective HCN-Channels blockers 188
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 185
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 184
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 182
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 182
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 181
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 181
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators 181
N,N-bis(alkanol)amine aryl esters and N,N-bis(cyclohexanol)amine aryl esters: Idantification of a new class of Pgp-dependent multidrug resistance (MDR) reverters andowed with potencies in the nanomolar range 181
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 180
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 178
Design of novel nicotinic ligands through 3D database searching 177
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 177
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 177
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 176
"Synthesis and binding properties of photoactivable Biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein" 176
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 175
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 175
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 172
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 172
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 170
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 169
Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors 168
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission 167
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation 167
The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats 167
Dual Inhibitors of P-gp and Carbonic Anhydrase XII (hCA XII) against Tumor Multidrug Resistance with Piperazine Scaffold 164
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 163
[35S]GTPgammaS binding studies of amphiphilic drugs-activated Gi proteins: A caveat 163
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 162
The piperazine scaffold for novel drug discovery efforts: the evidence to date 161
Exploratory chemistry toward the identification of a new class of MDR reverters inspired by pervilleine and verapamil models 160
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 160
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 158
Novel psychoplastogen DM506 reduces cue-induced heroin-seeking and inhibits tonic GABA currents in the Prelimbic Cortex 157
Analoghi a ridotta flessibilità molecolare di nuovi farmaci ad azione nootropa ed analgesica 157
Synthetic approaches to piperazine-containing drugs approved by FDA in the period of 2011–2023 156
A recombinant transductor-effector system: in vitro study of G inhibitor protein (G-alfa-i1)direct activators 156
Synthesis and pharmacological characterization of chiral pyrrolidinylfuran derivatives: the discovery of new functionally selective muscarinic agonists 154
HCN Channels Modulators: The Need for Selectivity 154
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs 154
Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4-Substituted Quinazoline Derivatives 154
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 153
Design, synthesis and electrophysiological studies of new blockers of HCN channels 152
Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity 152
Modulazione molecolare di antagonisti muscarinici. Sintesi e valutazione farmacologica preliminare di esteri amminoalchil piperazinici e piperidinici dell'acido 2,2-difenil-2-etiltioacetico 152
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235 151
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers 149
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs 148
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 148
Inhibition of P-glycoprotein-mediated multidrug resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: structure-activity relationships 148
Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]2 nonan-8-ones as Potential Nootropic and Analgesic Drugs 147
Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure 147
Synthesis and pharmacological evaluation of some (pyridyl)cyclopropylmethyl amines and their methiodides as nicotinic receptor ligands. 147
Non-hallucinogenic compounds derived from iboga alkaloids alleviate neruopathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation 146
Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat 146
Design, synthesis and preliminary pharmacological evaluation of 1,4-diaminobenzenes and 1,4-diaminocyclohexanes as cognition modulators 143
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 143
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs 143
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents. 143
DM232 and DM235, two potent cognition-enhancers, increase NO levels in rat adipocytes 142
Totale 19.558
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Categoria #
all - tutte 71.747
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 71.747
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021166 0 0 0 0 0 0 0 0 0 0 0 166
2021/20221.021 28 142 80 33 25 38 55 54 28 35 207 296
2022/20232.729 251 440 129 224 174 538 369 169 279 12 87 57
2023/20241.364 41 125 185 71 83 216 30 462 21 36 46 48
2024/20257.469 257 742 476 1.018 2.128 1.170 130 451 320 173 283 321
2025/20268.484 871 1.136 686 590 946 364 992 404 547 520 246 1.182
Totale 26.609