SUPURAN, CLAUDIU TRANDAFIR
 Distribuzione geografica
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Continente #
NA - Nord America 84.676
EU - Europa 26.867
AS - Asia 6.315
AF - Africa 74
SA - Sud America 44
Continente sconosciuto - Info sul continente non disponibili 19
OC - Oceania 10
Totale 118.005
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Nazione #
US - Stati Uniti d'America 84.497
PL - Polonia 7.263
IE - Irlanda 5.235
IT - Italia 3.965
SE - Svezia 3.353
RU - Federazione Russa 2.996
HK - Hong Kong 2.736
CN - Cina 1.325
FI - Finlandia 1.124
SG - Singapore 819
GB - Regno Unito 801
DE - Germania 691
GR - Grecia 413
TR - Turchia 405
UA - Ucraina 387
VN - Vietnam 365
IN - India 321
ES - Italia 291
JO - Giordania 185
CA - Canada 178
CH - Svizzera 88
NL - Olanda 73
FR - Francia 72
KR - Corea 66
BE - Belgio 47
EG - Egitto 32
BR - Brasile 29
JP - Giappone 23
IR - Iran 21
EU - Europa 18
MU - Mauritius 17
RO - Romania 16
AT - Austria 14
PK - Pakistan 11
SA - Arabia Saudita 8
AR - Argentina 7
NZ - Nuova Zelanda 7
SC - Seychelles 7
BG - Bulgaria 6
BY - Bielorussia 6
CO - Colombia 6
PH - Filippine 6
DK - Danimarca 5
ZA - Sudafrica 5
CZ - Repubblica Ceca 4
IL - Israele 4
AU - Australia 3
DZ - Algeria 3
ID - Indonesia 3
LT - Lituania 3
MA - Marocco 3
MY - Malesia 3
NO - Norvegia 3
PT - Portogallo 3
ET - Etiopia 2
GE - Georgia 2
GH - Ghana 2
LV - Lettonia 2
NG - Nigeria 2
SK - Slovacchia (Repubblica Slovacca) 2
TJ - Tagikistan 2
UZ - Uzbekistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AF - Afghanistan, Repubblica islamica di 1
AZ - Azerbaigian 1
BJ - Benin 1
EE - Estonia 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LI - Liechtenstein 1
MN - Mongolia 1
MT - Malta 1
MX - Messico 1
PE - Perù 1
PS - Palestinian Territory 1
RS - Serbia 1
TH - Thailandia 1
VE - Venezuela 1
Totale 118.005
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Città #
Fairfield 18.472
Woodbridge 8.552
Ashburn 8.198
Seattle 7.668
Warsaw 7.257
Cambridge 6.954
Houston 6.660
Wilmington 5.623
Dublin 5.210
Chandler 3.624
Lawrence 2.520
Altamura 2.514
Ann Arbor 2.404
Princeton 1.876
Hong Kong 1.274
Jacksonville 928
Boston 870
Medford 860
Boardman 792
San Diego 717
Moscow 661
Florence 532
Beijing 518
Singapore 464
Dong Ket 341
Athens 335
Falls Church 295
Barcelona 277
Norwalk 264
Izmir 256
Shanghai 225
Hillsboro 198
London 190
West Jordan 180
Toronto 150
Kent 149
New York 132
Andover 128
Bern 86
Dearborn 78
Buffalo 76
Phoenix 73
Los Angeles 70
Washington 68
Düsseldorf 67
Rome 65
Redwood City 61
Redmond 59
Guangzhou 55
Gavirate 53
Laurel 53
Tappahannock 52
Milan 45
Kilburn 42
Delhi 41
Brussels 39
Seoul 39
Pune 37
Scandicci 36
Wuhan 35
Naples 31
Prescot 31
Frankfurt am Main 30
Aigaleo 26
Chiswick 25
Detroit 24
Lappeenranta 24
Shenzhen 24
Nanjing 23
Castelliri 21
Siena 21
Hounslow 20
Chennai 19
Rui'an 19
New Bedfont 18
San Mateo 18
Acton 16
Chicago 16
Fuzhou 16
Wandsworth 16
Irpin 15
Messina 15
Naaldwijk 15
São Paulo 15
Mumbai 14
Seongnam 14
Southwark 14
Cagliari 13
Leawood 13
Auburn Hills 12
Giza 12
Helsinki 12
Istanbul 12
Vienna 12
Esslingen am Neckar 11
Hanover 11
Montréal 11
Prato 11
Chieti 10
Grevenbroich 10
Totale 100.188
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Nome #
How many carbonic anhydrase inhibition mechanisms exist? 490
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. 255
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? 253
Root effect hemoglobin may have evolved to enhance general tissue oxygen delivery 245
Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors. 245
Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II), Cu(II), Ni(II), and Zn(II) Complexes With Amino Acid-Derived Compounds. 243
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. 240
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. 240
Interfering with pH regulation in tumours as a therapeutic strategy. 238
PLASMATIC CARBONIC ANHYDRASE IX AS A DIAGNOSTIC MARKER FOR CLEAR CELL RENAL CELL CARCINOMA 231
Microbial enzyme: applications in industry and in bioremediation. 230
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. 229
Carbonic anhydrases activation with 3-amino-1H-1,2,4-triazole-1-carboxamides: Discovery of subnanomolar isoform II activators 228
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II. 225
Inhibition of Bacterial Carbonic Anhydrases as a Novel Approach to Escape Drug Resistance 222
Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity. 220
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis 218
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis 216
Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis 214
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. 214
Assembly comprising an absorber of near infrared (nir) light covalently linked to an inhibitor of carbonic anhydrase 212
Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: Towards new carbonic anhydrase glycoinhibitors 212
Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors 211
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. 210
CO2 and HCO3- Permeability of the Rat Liver Mitochondrial Membrane 209
Natural product coumarins that inhibit human carbonic anhydrases. 208
Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms. 205
Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model 200
Natural product polyamines that inhibit human carbonic anhydrases 198
Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII 196
Ascaris lumbricoides β carbonic anhydrase: A potential target enzyme for treatment of ascariasis 195
Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII 194
Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect 194
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors. 194
Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae 191
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. 189
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates 189
Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae 185
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform 169
Amino acids as building blocks for carbonic anhydrase inhibitors 168
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives? 168
1,3,4-thiadiazole derivatives. Part 9. Synthesis and biological activity of metal complexes of 5-(2-aminoethyl)-2-amino-1,3,4-thiadiazole. 155
Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII 151
The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy 150
Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase 147
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines 145
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors 144
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions 144
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition 143
7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring. 141
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects. 140
Next-generation dithiocarbamate carbonic anhydrase inhibitors 140
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology 138
Diuretics with carbonic anhydrase inhibitory action: A patent and literature review (2005-2013) 138
Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme. 137
Exploring QSARs of some benzenesulfonamides incorporating cyanoacrylamide moieties as a carbonic anhydrase inhibitors (specifically against tumor-associated isoforms IX and XII) 135
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action 134
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival 134
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX) 134
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases. 133
Complexes With Biologically Active Ligands. Part 6 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase. 132
Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor. 130
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. 129
Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights 129
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX 128
3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors. 126
Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII 126
A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease 125
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense. 124
Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors 124
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads 123
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties 123
Non-classical inhibition of carbonic anhydrase 123
Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. 121
Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA. 120
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer 120
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. 120
Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators 120
Electron impact mass spectral interpretation for some thiophosphoryl-p-acetylaminobenzenesulfonamides. 119
Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. 118
Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances. 118
Antiglaucoma carbonic anhydrase inhibitors: a patent review. 118
Metal based isatin-derived sulfonamides: their synthesis, characterization, coordination behavior and biological activity. 118
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. 117
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors 117
Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies 117
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI. 116
Unsymmetrical 1,1'-disubstituted ferrocenes: synthesis of Co(ii), Cu(ii), Ni(ii) and Zn(ii) chelates of ferrocenyl -1-thiadiazolo-1'-tetrazole, -1-thiadiazolo-1'-triazole and -1-tetrazolo-1'-triazole with antimicrobial properties. 116
In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos 116
Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. 116
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles. 116
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors. 115
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. 114
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors. 114
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. 114
Mycobacterium tuberculosisβ-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs 114
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. 114
Antiobesity carbonic anhydrase inhibitors: a literature and patent review. 114
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates. 113
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions. 113
Totale 16.466
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Categoria #
all - tutte 390.937
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 390.937
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202032.585 0 1.815 925 2.824 4.420 4.452 4.607 4.526 4.306 2.051 1.825 834
2020/202116.829 1.593 1.733 1.061 1.342 1.017 1.734 787 1.223 1.807 2.026 1.269 1.237
2021/20229.858 433 924 1.175 301 273 530 491 741 585 479 1.041 2.885
2022/202321.752 2.862 5.585 530 1.087 1.497 3.915 2.162 830 1.675 616 636 357
2023/20248.757 326 878 1.941 506 562 1.113 289 1.625 180 735 381 221
2024/20253.618 2.489 1.129 0 0 0 0 0 0 0 0 0 0
Totale 119.637