SUPURAN, CLAUDIU TRANDAFIR
 Distribuzione geografica
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Continente #
NA - Nord America 138.977
EU - Europa 62.668
AS - Asia 59.447
SA - Sud America 11.341
AF - Africa 2.049
Continente sconosciuto - Info sul continente non disponibili 1.912
OC - Oceania 1.181
Totale 277.575
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Nazione #
US - Stati Uniti d'America 136.804
RU - Federazione Russa 21.476
SG - Singapore 16.607
IT - Italia 15.669
CN - Cina 14.694
BR - Brasile 9.165
HK - Hong Kong 8.124
PL - Polonia 7.381
VN - Vietnam 6.828
KR - Corea 6.129
IE - Irlanda 5.264
SE - Svezia 3.476
FR - Francia 2.145
IN - India 2.099
FI - Finlandia 2.082
DE - Germania 1.564
CA - Canada 1.267
GB - Regno Unito 1.247
AU - Australia 1.154
BD - Bangladesh 1.071
AR - Argentina 846
ID - Indonesia 672
TR - Turchia 659
UA - Ucraina 535
CI - Costa d'Avorio 494
JP - Giappone 469
GR - Grecia 427
ES - Italia 408
EC - Ecuador 401
NG - Nigeria 399
IQ - Iraq 393
MX - Messico 391
NL - Olanda 304
JO - Giordania 278
ZA - Sudafrica 260
CO - Colombia 238
PK - Pakistan 206
MA - Marocco 196
PY - Paraguay 179
EG - Egitto 167
VE - Venezuela 166
SA - Arabia Saudita 140
UZ - Uzbekistan 138
CL - Cile 129
PH - Filippine 118
BJ - Benin 115
CH - Svizzera 111
PE - Perù 102
DZ - Algeria 92
AE - Emirati Arabi Uniti 86
KE - Kenya 85
JM - Giamaica 83
TN - Tunisia 80
TW - Taiwan 74
CR - Costa Rica 72
BE - Belgio 71
UY - Uruguay 71
HN - Honduras 67
AT - Austria 66
NP - Nepal 65
AZ - Azerbaigian 63
KZ - Kazakistan 63
LT - Lituania 56
MY - Malesia 56
CZ - Repubblica Ceca 55
AL - Albania 50
IR - Iran 50
OM - Oman 49
TT - Trinidad e Tobago 45
RO - Romania 44
DO - Repubblica Dominicana 40
GT - Guatemala 38
BO - Bolivia 37
LB - Libano 36
SV - El Salvador 36
IL - Israele 35
TH - Thailandia 32
PT - Portogallo 30
ET - Etiopia 29
PS - Palestinian Territory 29
SN - Senegal 29
PA - Panama 27
KG - Kirghizistan 26
PR - Porto Rico 26
DK - Danimarca 25
BG - Bulgaria 22
BY - Bielorussia 22
RS - Serbia 21
BH - Bahrain 20
MU - Mauritius 20
NI - Nicaragua 20
NZ - Nuova Zelanda 20
EU - Europa 18
KW - Kuwait 17
QA - Qatar 17
BA - Bosnia-Erzegovina 15
BB - Barbados 15
GE - Georgia 15
HU - Ungheria 15
LV - Lettonia 15
Totale 275.377
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Città #
Ashburn 19.053
Fairfield 18.474
Santa Clara 18.446
Singapore 12.420
Woodbridge 8.557
Seattle 7.726
Warsaw 7.343
Cambridge 6.988
Houston 6.742
Hong Kong 6.510
Seoul 6.064
Wilmington 5.635
Dublin 5.236
Hefei 4.632
Chandler 3.624
San Jose 3.555
Milan 3.441
Lawrence 2.524
Altamura 2.516
Ann Arbor 2.406
Ho Chi Minh City 2.200
Princeton 1.881
The Dalles 1.727
Beijing 1.715
Lauterbourg 1.692
Los Angeles 1.636
Moscow 1.473
Hanoi 1.465
Rome 1.452
Council Bluffs 1.138
Melbourne 1.101
Dallas 1.094
Buffalo 1.047
Mumbai 990
Florence 982
Jacksonville 954
Boston 946
Boardman 904
Medford 865
San Diego 745
São Paulo 705
Helsinki 658
Kent 565
New York 525
Clifton 500
Abidjan 493
Munich 455
Naples 427
Abuja 386
Tokyo 386
Jakarta 373
Redondo Beach 369
Shanghai 356
Athens 350
Turin 345
Dong Ket 341
Da Nang 305
Falls Church 295
Toronto 294
Barcelona 284
London 281
Bengaluru 276
Rio de Janeiro 273
Norwalk 272
Chicago 271
Bologna 268
Izmir 267
Haiphong 251
Figino 237
Paris 237
Frankfurt am Main 216
Hillsboro 206
Guangzhou 205
Phoenix 198
Miano 194
Belo Horizonte 191
West Jordan 190
Brasília 188
Lappeenranta 186
Orem 186
Palermo 170
Montreal 163
Tianjin 155
Curitiba 145
Biên Hòa 142
Guayaquil 142
Baghdad 138
Atlanta 136
Brooklyn 136
Porto Alegre 135
Quito 130
Bari 129
Andover 128
Turku 126
Hải Dương 123
Washington 123
Tashkent 121
Yubileyny 117
Cotonou 115
Venice 112
Totale 193.590
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Nome #
How many carbonic anhydrase inhibition mechanisms exist? 577
Interfering with pH regulation in tumours as a therapeutic strategy. 472
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. 439
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms? 390
Computational approaches in drug discovery: strategies to address polypharmacology and the synthesis/optimization of lead compounds 383
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis 381
Root effect hemoglobin may have evolved to enhance general tissue oxygen delivery 366
Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors. 343
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. 340
Assembly comprising an absorber of near infrared (nir) light covalently linked to an inhibitor of carbonic anhydrase 337
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. 335
PLASMATIC CARBONIC ANHYDRASE IX AS A DIAGNOSTIC MARKER FOR CLEAR CELL RENAL CELL CARCINOMA 325
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II. 324
Carbonic anhydrases activation with 3-amino-1H-1,2,4-triazole-1-carboxamides: Discovery of subnanomolar isoform II activators 317
Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity. 316
Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II), Cu(II), Ni(II), and Zn(II) Complexes With Amino Acid-Derived Compounds. 311
Orbital symmetry in QSAR: some Schiff's base inhibitors of carbonic anhydrase. 310
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis 308
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 308
Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII 307
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. 306
Inhibition of Bacterial Carbonic Anhydrases as a Novel Approach to Escape Drug Resistance 304
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. 303
Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors 302
Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae 302
Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis 300
Natural product polyamines that inhibit human carbonic anhydrases 299
Microbial enzyme: applications in industry and in bioremediation. 299
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. 296
Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms. 291
CO2 and HCO3- Permeability of the Rat Liver Mitochondrial Membrane 286
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates 286
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 283
Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection? 282
Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect 281
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases. 279
7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring. 279
Ascaris lumbricoides β carbonic anhydrase: A potential target enzyme for treatment of ascariasis 278
Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: Towards new carbonic anhydrase glycoinhibitors 277
Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors. 276
Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII 275
Amino acids as building blocks for carbonic anhydrase inhibitors 274
Natural product coumarins that inhibit human carbonic anhydrases. 273
Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model 272
Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae 272
Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. 270
Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines 269
1,3,4-thiadiazole derivatives. Part 9. Synthesis and biological activity of metal complexes of 5-(2-aminoethyl)-2-amino-1,3,4-thiadiazole. 269
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer 268
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles. 267
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads 266
Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency 265
Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors 264
S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. 262
Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase 261
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform 260
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors 259
Diuretics with carbonic anhydrase inhibitory action: A patent and literature review (2005-2013) 254
A New Kid on the Block? Carbonic Anhydrases as Possible New Targets in Alzheimer's Disease 253
1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions 247
4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies 244
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action 240
Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII 239
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX) 238
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology 236
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives? 235
PET Imaging of Carbonic Anhydrase IX Expression of HT-29 Tumor Xenograft Mice with 68Ga-Labeled Benzenesulfonamides 233
Biochemical characterization of the δ-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA 231
Next-generation dithiocarbamate carbonic anhydrase inhibitors 231
Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII 230
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 230
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII 229
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival 228
1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy 228
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus. 227
Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides 227
Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases 227
Geographical characterization by MAE-HPLC and NIR methodologies and carbonic anhydrase inhibition of Saffron components 226
Pain relieving effect of-NSAIDS-CAIs hybrid molecules: Systemic and intra-articular treatments against rheumatoid arthritis 226
Exploring QSARs of some benzenesulfonamides incorporating cyanoacrylamide moieties as a carbonic anhydrase inhibitors (specifically against tumor-associated isoforms IX and XII) 225
Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect against Amyloid-β-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction 224
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors. 224
The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors 224
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy 224
The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy 222
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. 218
Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties 218
Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides 216
Novel diamide-based benzenesulfonamides as selective carbonic anhydrase ix inhibitors endowed with antitumor activity: Synthesis, biological evaluation and in silico insights 216
Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX 216
Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors 215
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 215
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects. 215
Structural modulation of the biological activity of gold nanoparticles functionalized with a carbonic anhydrase inhibitor. 214
[(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX. 214
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects 214
3D QSAR selectivity analyses of carbonic anhydrase inhibitors: insights for the design of isozyme selective inhibitors. 213
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 213
ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme 213
Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action 213
Totale 27.269
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Categoria #
all - tutte 808.018
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 808.018
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20229.425 0 924 1.175 301 273 530 491 741 585 479 1.041 2.885
2022/202321.752 2.862 5.585 530 1.087 1.497 3.915 2.162 830 1.675 616 636 357
2023/20248.757 326 878 1.941 506 562 1.113 289 1.625 180 735 381 221
2024/202559.919 2.489 7.101 3.878 7.851 16.321 6.486 1.200 2.594 4.522 1.928 2.378 3.171
2025/202696.913 7.324 13.397 11.113 10.674 7.839 3.475 9.860 5.587 6.250 5.565 3.338 12.491
2026/20274.724 3.732 992 0 0 0 0 0 0 0 0 0 0
Totale 277.575