ROMANELLI, MARIA NOVELLA
 Distribuzione geografica
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Continente #
NA - Nord America 19.775
EU - Europa 13.836
AS - Asia 8.717
SA - Sud America 1.001
Continente sconosciuto - Info sul continente non disponibili 346
AF - Africa 226
OC - Oceania 155
Totale 44.056
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Nazione #
US - Stati Uniti d'America 19.356
RU - Federazione Russa 3.893
IT - Italia 2.847
PL - Polonia 2.511
SG - Singapore 2.469
CN - Cina 2.022
HK - Hong Kong 1.362
IE - Irlanda 1.011
VN - Vietnam 976
SE - Svezia 951
BR - Brasile 789
KR - Corea 762
DE - Germania 647
UA - Ucraina 456
FI - Finlandia 455
FR - Francia 387
IN - India 311
GB - Regno Unito 307
CA - Canada 265
JP - Giappone 150
AU - Australia 149
BD - Bangladesh 140
TR - Turchia 86
ID - Indonesia 81
JO - Giordania 81
NL - Olanda 80
MX - Messico 69
AR - Argentina 67
CH - Svizzera 66
IQ - Iraq 59
CI - Costa d'Avorio 49
ES - Italia 49
BE - Belgio 45
ZA - Sudafrica 40
PK - Pakistan 33
CO - Colombia 31
NG - Nigeria 30
SC - Seychelles 30
AT - Austria 29
EC - Ecuador 27
CL - Cile 26
VE - Venezuela 23
UZ - Uzbekistan 19
MA - Marocco 16
SA - Arabia Saudita 16
AZ - Azerbaigian 15
JM - Giamaica 15
PH - Filippine 15
RO - Romania 15
IL - Israele 14
CZ - Repubblica Ceca 13
PE - Perù 13
PY - Paraguay 13
CR - Costa Rica 12
DZ - Algeria 11
KE - Kenya 11
LT - Lituania 11
TT - Trinidad e Tobago 11
TW - Taiwan 11
EG - Egitto 10
MY - Malesia 10
KZ - Kazakistan 9
PT - Portogallo 9
TH - Thailandia 9
AE - Emirati Arabi Uniti 8
LB - Libano 8
NP - Nepal 8
TN - Tunisia 8
GT - Guatemala 7
HN - Honduras 7
HU - Ungheria 6
KG - Kirghizistan 6
NI - Nicaragua 6
NZ - Nuova Zelanda 6
PR - Porto Rico 6
SK - Slovacchia (Repubblica Slovacca) 6
BG - Bulgaria 5
BJ - Benin 5
DK - Danimarca 5
IR - Iran 5
SN - Senegal 5
AL - Albania 4
AM - Armenia 4
BH - Bahrain 4
BO - Bolivia 4
HR - Croazia 4
MO - Macao, regione amministrativa speciale della Cina 4
NO - Norvegia 4
OM - Oman 4
SI - Slovenia 4
UY - Uruguay 4
BS - Bahamas 3
BY - Bielorussia 3
CY - Cipro 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
EU - Europa 3
GE - Georgia 3
GR - Grecia 3
PS - Palestinian Territory 3
Totale 43.669
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Città #
Santa Clara 3.887
Warsaw 2.493
Ashburn 2.146
Singapore 1.761
Fairfield 1.389
Hong Kong 1.143
Chandler 1.141
Dublin 1.002
Seoul 710
Jacksonville 665
Woodbridge 645
Cambridge 574
Seattle 556
Houston 552
San Jose 529
Milan 486
Wilmington 484
Council Bluffs 441
Beijing 417
Hefei 410
Buffalo 368
Los Angeles 356
Ann Arbor 312
The Dalles 289
Princeton 258
Rome 238
Altamura 237
Ho Chi Minh City 223
Munich 218
Florence 212
Lauterbourg 211
Boston 209
Lawrence 205
Hanoi 203
Dong Ket 199
Mumbai 173
Dallas 163
Helsinki 149
Moscow 147
Melbourne 142
Tokyo 142
New York 136
Boardman 129
Medford 104
Kent 91
Shanghai 91
San Diego 90
Paris 77
São Paulo 70
Naples 66
Turku 65
Phoenix 61
Turin 59
Bern 57
Jakarta 54
Bologna 53
Chicago 53
Orem 51
Toronto 51
Norwalk 50
Abidjan 49
London 49
Guangzhou 48
Montreal 47
Frankfurt am Main 45
Falls Church 44
Clifton 43
Brussels 41
Philadelphia 40
Seongnam 40
Verona 39
Figino 38
Washington 38
Bari 37
Columbus 37
Haiphong 37
Redondo Beach 37
Hillsboro 36
Izmir 36
West Jordan 35
Lappeenranta 34
Da Nang 31
Genoa 31
Tianjin 30
Abuja 29
Chennai 29
Frankfurt Am Main 27
Denver 26
Brooklyn 25
Palermo 23
San Francisco 23
Andover 22
Johannesburg 22
Nuremberg 22
Amsterdam 21
Miano 21
Venice 21
Brescia 20
Vienna 20
Yubileyny 20
Totale 28.806
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Nome #
DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer 684
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 428
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 415
Design, synthesis and binding affinity of new nicotinic ligands 353
Effectiveness of the histone deacetylase inhibitor (S)-2 against LNCaP and PC3 human prostate cancer cells 328
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis. 326
New isoform-selective HCN blockers 325
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers 315
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 308
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators 308
PHARMACOLOGICAL CHARACTERIZATION OF THE NOVEL ACH RELEASER A-TROPANYL 2-(4-BROMOPHENYL)PROPIONATE (PG-9). 307
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 303
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy 296
DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP) 294
ANTINOCICEPTION INDUCED BY SM32 DEPENDS ON CENTRAL CHOLINERGIC MECHANISM 287
The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells 284
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 283
Amino acids as building blocks for carbonic anhydrase inhibitors 275
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 275
STEREOSELECTIVE INCREASE IN CHOLINERGIC TRANSMISSION BY R-(+)- HYOSCYAMINE 273
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer 269
THE FROZEN ANALOG APPROACH IN MEDICINAL CHEMISTRY 264
Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density 260
1,3-MIGRATION OF CHLORIDE AND AZIDE SUBSTITUENTS WITHIN ORGANOSILICON CATIONS, AND ANCHIMERIC ASSISTANCE BY THE AZIDO GROUP 259
1,3-oxathiolane muscarinic ligands modified at the cationic head. 259
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 254
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3∗ Nicotinic Receptors 251
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 250
Binding Profiles of a Series of 2-Arylpropionic Acid Esters on Cloned Human Muscarinic Receptors Subtypes (m1-m5) and Their Relationship to Nootropic Activity 248
The hyperpolarization-activated HCN4 channel is Important for proper maintenance of oscillatory activity in the thalamocortical system 248
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 246
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 238
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 236
Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain 231
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 231
2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity 230
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent Pgp-dependent multidrug resistance (MDR) inhibitors 223
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 219
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents 218
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). 216
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 216
Central Nicotinic receptors: structure, function, ligands, and therapeutic potential 216
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 215
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 215
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 214
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 213
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 211
Analgesic effects of myrrh 211
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 209
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 209
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 208
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 208
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 208
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 206
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 206
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 205
CHARACTERIZATION OF THE ACTION ON CENTRAL OPIOID RECEPTORS OF FURANOEUDESMA-1,3-DIENE, A SESQUITERPENE EXTRACTED FROM MYRRH 205
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 205
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Colitis-Associated Visceral Pain in Rats 204
Carbachol dimers as homobivalent modulators of muscarinic receptors 203
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators 202
Aminoarylesters as multidrug resistance (MDR) reverting agents endowed with high potency and efficacy 200
ANALGESIC, ANTIMUSCARINIC ACTIVITY AND ENANTIOSELECTIVITY OF THE FOUR ISOMERS OF 3-QUINUCLIDINYL TROPATE AS COMPARED WITH THE ENANTIOMERS OF HYOSCYAMINE 198
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 195
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 195
(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation 195
Recent advances in the discovery of Nicotinic acetylcholine receptor allosteric modulators 193
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 192
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 191
New phenylalkylamines as isoform selective HCN-Channels blockers 190
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 188
Design, synthesis and pharmacological evaluation of some frozen-analogues of DMPP 187
GRIND-derived pharmacophore model for a series of α-tropanyl derivative ligands of the sigma-2 receptor 184
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers 184
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents 184
2- or 3-Substituted piperazines as nootropic agents: carbethoxy and hydroxymethyl analogues of the cognition-enhancer DM235 184
GRID INDEPENDENT DESCRIPTORS (GRIND) IN THE STUDY OF THE S-RECEPTOR SUBTYPE SELECTIVITY. 183
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 183
New dual P-Glycoprotein (P-gp) and human carbonic anhydrase XII (hCA XII) inhibitors as Multidrug Resistance (MDR) reversers in cancer cells 182
SYNTHESIS AND BIOLOGICAL ACTIVITY OF A SERIES OF ARYL TROPANYL ESTERS AND AMIDES CHEMICALLY RELATED TO 1H-INDOLE-3-CARBOXYLIC ACID ENDO 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER 181
Design of novel nicotinic ligands through 3D database searching 181
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 181
P-glycoprotein and carbonic anhydrases hybrid inhibitors: a new strategy to reverse multidrug resistance (MDR) in cancer cells 180
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 179
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 179
"Synthesis and binding properties of photoactivable Biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein" 179
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 179
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 178
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 177
Ibogalogs decrease neuropathic pain in mice through a mechanism involving crosstalk between 5-HT2A and mGlu2 receptors 176
PRESYNAPTIC AUTO- AND HETERO-RECEPTORS IN THE CHOLINERGIC REGULATION OF PAIN 175
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 175
Attività analgesica e antimuscarinica ed enantioselettività dei quattro isomeri del tropato del 3-chinuclidinolo messe a confronto con gli enantiomeri della iosciamina 175
MOLECULAR MODULATION OF MUSCARINIC ANTAGONISTS. SYNTHESIS AND PHARMACOLOGICAL PROFILE OF 2,2-DIPHENYL-2-ETHYLTHIOACETIC AND 3,3-DIPHENYL-3-ETHYLTHIOPROPIONIC ACID DERIVATIVES CHARACTERIZED BY A DIPEPTIDE SPACER 175
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. 175
Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors 175
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 174
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators 174
The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats 173
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission 171
Totale 23.026
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Categoria #
all - tutte 120.249
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 120.249
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.671 0 217 106 69 52 66 89 116 57 61 360 478
2022/20234.462 396 757 196 343 340 847 573 269 469 28 143 101
2023/20241.862 68 197 285 88 137 306 74 410 40 87 90 80
2024/202511.370 428 1.168 738 1.538 3.147 1.674 260 732 532 274 444 435
2025/202613.304 1.399 1.790 1.287 878 1.449 586 1.511 639 887 736 396 1.746
2026/2027852 504 348 0 0 0 0 0 0 0 0 0 0
Totale 44.056