ROMANELLI, MARIA NOVELLA
 Distribuzione geografica
Continente #
NA - Nord America 9.881
EU - Europa 7.114
AS - Asia 1.175
AF - Africa 36
SA - Sud America 7
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 4
Totale 18.221
Nazione #
US - Stati Uniti d'America 9.848
PL - Polonia 2.472
IE - Irlanda 1.080
IT - Italia 1.002
SE - Svezia 928
HK - Hong Kong 521
UA - Ucraina 441
DE - Germania 337
FI - Finlandia 218
VN - Vietnam 206
GB - Regno Unito 205
CN - Cina 197
AT - Austria 138
BE - Belgio 85
JO - Giordania 63
CH - Svizzera 61
FR - Francia 56
SG - Singapore 50
KR - Corea 46
TR - Turchia 43
IN - India 31
SC - Seychelles 30
CA - Canada 27
NL - Olanda 22
ES - Italia 16
RU - Federazione Russa 14
RO - Romania 10
CZ - Repubblica Ceca 9
MX - Messico 6
DZ - Algeria 4
HR - Croazia 4
JP - Giappone 4
MO - Macao, regione amministrativa speciale della Cina 4
NZ - Nuova Zelanda 4
EU - Europa 3
HU - Ungheria 3
IR - Iran 3
PT - Portogallo 3
AR - Argentina 2
BG - Bulgaria 2
CL - Cile 2
IL - Israele 2
SI - Slovenia 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
A1 - Anonimo 1
BR - Brasile 1
EC - Ecuador 1
KE - Kenya 1
LB - Libano 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
MU - Mauritius 1
PE - Perù 1
PH - Filippine 1
RS - Serbia 1
UZ - Uzbekistan 1
Totale 18.221
Città #
Warsaw 2.467
Fairfield 1.386
Chandler 1.141
Dublin 1.072
Ashburn 834
Jacksonville 658
Woodbridge 645
Cambridge 573
Seattle 544
Houston 542
Wilmington 482
Hong Kong 324
Ann Arbor 311
Princeton 258
Altamura 236
Lawrence 205
Dong Ket 199
Boston 191
Florence 157
Beijing 119
Buffalo 117
Boardman 106
Medford 104
Vienna 95
Brussels 83
San Diego 83
Bern 57
Norwalk 50
New York 46
Falls Church 44
Seongnam 40
Shanghai 40
Milan 39
Izmir 36
Philadelphia 33
Washington 33
Phoenix 28
Frankfurt Am Main 27
Hillsboro 27
Verona 25
Andover 22
Guangzhou 22
London 19
Lappeenranta 17
Toronto 17
Dearborn 15
Rome 15
Barcelona 14
Singapore 13
Salerno 12
Hanover 11
Auburn Hills 10
Gavirate 10
Los Angeles 10
Redwood City 10
Moscow 8
Gold 7
Manduria 7
Monza 7
Ottawa 7
Sesto Fiorentino 7
Treviglio 7
Düsseldorf 6
Menlo Park 6
Pune 6
Bremen 5
Brno 5
Kochi 5
Miami 5
Misano Adriatico 5
Moncalieri 5
Münster 5
Napoli 5
Scandicci 5
Siena 5
Cedar Knolls 4
Edinburgh 4
Genoa 4
Giugliano In Campania 4
Groningen 4
Laurel 4
Macao 4
Mcallen 4
Querétaro City 4
Tappahannock 4
Acerra 3
Acton 3
Amherst 3
Budapest 3
Calvisano 3
Fuzhou 3
Leawood 3
Nanjing 3
Nuremberg 3
Palmerston North 3
Pozzuoli 3
San Martino Buon Albergo 3
Seoul 3
Turate 3
Wroclaw 3
Totale 13.877
Nome #
DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer 298
Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity 276
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs 266
Design, synthesis and binding affinity of new nicotinic ligands 229
Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition-enhancers 227
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis. 222
Effectiveness of the histone deacetylase inhibitor (S)-2 against LNCaP and PC3 human prostate cancer cells 218
PHARMACOLOGICAL CHARACTERIZATION OF THE NOVEL ACH RELEASER A-TROPANYL 2-(4-BROMOPHENYL)PROPIONATE (PG-9). 216
New isoform-selective HCN blockers 214
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(phenylthio)- and 2-(phenylamino)alkanoic Acid Esters 213
ANTINOCICEPTION INDUCED BY SM32 DEPENDS ON CENTRAL CHOLINERGIC MECHANISM 199
Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density 196
Design, synthesis and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs. 194
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy 187
Binding Profiles of a Series of 2-Arylpropionic Acid Esters on Cloned Human Muscarinic Receptors Subtypes (m1-m5) and Their Relationship to Nootropic Activity 184
THE FROZEN ANALOG APPROACH IN MEDICINAL CHEMISTRY 174
The hyperpolarization-activated HCN4 channel is Important for proper maintenance of oscillatory activity in the thalamocortical system 171
Amino acids as building blocks for carbonic anhydrase inhibitors 165
DESIGN, SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF RIGID ANALOGUES OF THE NICOTINIC AGONIST 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE (DMPP) 155
Recent advances in the search of BCRP- and dual P-gp/BCRP-based multidrug resistance modulators 144
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 140
1,3-MIGRATION OF CHLORIDE AND AZIDE SUBSTITUENTS WITHIN ORGANOSILICON CATIONS, AND ANCHIMERIC ASSISTANCE BY THE AZIDO GROUP 139
The new low-toxic histone deacetylase inhibitor S-(2) induces apoptosis in various acute myeloid leukemia cells 135
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer 126
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters 123
Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain 119
1,3-oxathiolane muscarinic ligands modified at the cationic head. 117
STEREOSELECTIVE INCREASE IN CHOLINERGIC TRANSMISSION BY R-(+)- HYOSCYAMINE 115
Design, synthesis and preliminary biological evaluation of new isoform-selective f-current blockers. 115
FURTHER STRUCTURE-ACTIVITY RELATIONSHIPS IN THE SERIES OF TROPANYL ESTERS ENDOWED WITH POTENT ANTINOCICEPTIVE ACTIVITY 114
Synthesis and Cholinergic Affinity of Diastereomeric and Enantiomeric Isomers of 1-Methyl-2-(2-methyl-1,3-dioxolan-4-yl)-pyrrolidine, 1-Methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their Iodomethylates 112
Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands 111
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators 110
2-Benzylpiperazine: a new scaffold for potent human Carbonic Anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents. 110
Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent. 108
SYNTHESIS, AFFINITY PROFILE AND FUNCTIONAL ACTIVITY OF MUSCARINIC ANTAGONISTS WITH A 1-METHYL-2-(2,2-ALKYLARYL-1,3-OXATHIOLAN-5-YL)PYRROLIDINE STRUCTURE 108
Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents 107
Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist. 107
ISOMERIC N,N-BIS(CYCLOHEXANOL)AMINE ARYL ESTERS: THE DISCOVERY OF A NEW CLASS OF HIGHLY POTENT P-GLYCOPROTEIN (PGP)-DEPENDENT MULTIDRUG RESISTANCE (MDR) INHIBITORS 106
New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) 106
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine 106
Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP) 105
Antagonisti muscarinici a struttura 1,3-ossatiolano-2-pirrolidinica 102
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents 101
Synthesis and Enantioselectivity of the Enantiomers of PG9 and SM21, New Potent Analgesic and Cognition-Enhancing Drugs 100
Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue. 100
SAR STUDIES ON THE POTENT AND SELECTIVE MUSCARINIC ANTAGONIST 2-ETHYLTHIO-2,2-DIPHENYLACETIC ACID N,N-DIETHYLAMINOETHYL ESTER 99
CHARACTERIZATION OF THE ACTION ON CENTRAL OPIOID RECEPTORS OF FURANOEUDESMA-1,3-DIENE, A SESQUITERPENE EXTRACTED FROM MYRRH 99
DIFFERENTIAL ANALGESIC ACTIVITY OF THE ENANTIOMERS OF ATROPINE DERIVATIVES DOES NOT CORRELATE WITH THEIR MUSCARINIC SUBTYPE SELECTIVITY 99
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current 98
PRESYNAPTIC AUTO- AND HETERO-RECEPTORS IN THE CHOLINERGIC REGULATION OF PAIN 96
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives. 95
SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS 94
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring 94
COGNITION-ENHANCING DRUGS IN MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD): AN UPDATE[1] 93
SEMI-RIGID ANALOGUES OF THE CALCIUM ANTAGONIST VERAPAMIL: A MOLECULAR MODELLING STUDY 92
Design of novel nicotinic ligands through 3D database searching 92
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers 92
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR) 92
UNEXPECTED REACTIONS OF 2-NITRO-FLUORENE-9-CARBOXYLIC ACID 91
Central Nicotinic receptors: structure, function, ligands, and therapeutic potential 91
Carbachol dimers as homobivalent modulators of muscarinic receptors 91
Dual P-glycoprotein and CA XII inhibitors: A new strategy to reverse the P-gp Mediated Multidrug Resistance (MDR) in cancer cells y 90
PREPARATION AND SOME REACTIONS OF THE COMPOUNDS OF THE TYPE (ME3SI)2C(SIME2OME)(SIME2X). ANCHIMERIC ASSISTANCE BY THE METHOXY GROUP 90
GRIND-derived pharmacophore model for a series of α-tropanyl derivative ligands of the sigma-2 receptor 89
The quest for the treatment of cognitive impairment: alpha 7 nicotinic and alpha 5 GABA-A receptor modulators 88
Updates on HCN channels in the heart: Function, Dysfunction and pharmacology 88
Synthesis of Hexahydro-[2]pyrindine(=Hexahydrocyclopenta[c]pyridine) Derivatives as Conformationally Restricted Analogs of the Nicotinic Ligands Arecolone and Isoarecolone 88
Muscarinic antagonists with multiple stereocenters: synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives 88
STRUCTURAL DEPENDENCE OF THE ALLOSTERIC INTERACTION OF SEMI-RIGID VERAPAMIL ANALOGUES WITH DIHYDROPYRIDINE-BINDING IN KITTEN HEART 87
Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. 87
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators 87
REDUCED FLEXIBILITY ANALOGS OF ANALGESIC AND COGNITION-ENHANCING A-TROPANYL ESTERS 86
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters 86
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 86
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent 86
N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy 85
Design, synthesis and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins. 85
VERAPAMIL ANALOGUES WITH RESTRICTED MOLECULAR FLEXIBILITY: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF THE FOUR ISOMERS OF ALPHA-[1-[3-[N-[1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]]-N-METHYLAMINO]CYCLOHEXYL]]-ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZENEACETONITRILE 84
THE FIRST SILICON THIOCYANATE 84
UNIMOLECULAR ALCOHOLYSIS OF ORGANOSILICON HALIDES OF THE TYPE (ME3SI)2C(SIME2OME)(SIR2X). ANCHIMERIC ASSISTANCE BY AND MIGRATION OF THE OME GROUP 84
"Synthesis and binding properties of photoactivable Biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein" 84
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors 84
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists. 83
WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential 83
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs 83
1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs 83
1,4-Diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic drugs 83
Arylamino Esters as P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 82
AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). 81
Analgesic effects of myrrh 81
The novel nootropic drugs DM232 (Unifiram) and DM235 (Sunifiram) ameliorate memory impairment in mice and rats 81
Design, synthesis and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain 81
HCN Channels Modulators: The Need for Selectivity 80
The new HDAC1 inhibitor LG325 ameliorates neuropathic pain in a mouse model 80
Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: further restriction of molecular flexibility maintains high potency and efficacy 78
EUDISMIC ANALYSIS OF A SERIES OF MUSCARINIC LIGANDS CARRYING A 1,3-OXATHIOLANE NUCLEUS 78
EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues 78
The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: from Biophysics to Pharmacology of a Unique Family of Ion Channels 78
Designing selective modulators for the nicotinic receptor subtypes: challenges and opportunities 78
Totale 11.785
Categoria #
all - tutte 49.155
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.155


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.326 0 0 0 0 0 0 0 0 92 272 533 429
2019/20203.631 292 321 100 331 386 425 352 471 326 207 363 57
2020/20212.932 227 189 179 285 123 398 126 278 211 432 137 347
2021/20221.724 53 217 106 69 52 66 89 116 57 61 360 478
2022/20234.648 396 757 196 343 340 847 662 301 479 41 172 114
2023/20241.683 94 209 296 109 158 306 74 410 27 0 0 0
Totale 18.537