STEFANI, MASSIMO
 Distribuzione geografica
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Continente #
EU - Europa 8.640
NA - Nord America 8.151
AS - Asia 1.266
AF - Africa 29
SA - Sud America 28
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 6
Totale 18.126
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Nazione #
US - Stati Uniti d'America 8.131
PL - Polonia 4.102
RU - Federazione Russa 882
SE - Svezia 840
IE - Irlanda 803
IT - Italia 792
UA - Ucraina 395
HK - Hong Kong 376
DE - Germania 347
SG - Singapore 277
CN - Cina 189
FI - Finlandia 183
VN - Vietnam 161
IN - India 132
GB - Regno Unito 125
TR - Turchia 60
FR - Francia 54
JO - Giordania 48
ES - Italia 43
CH - Svizzera 22
SC - Seychelles 21
BR - Brasile 20
CA - Canada 17
NL - Olanda 17
KR - Corea 12
BE - Belgio 10
BG - Bulgaria 6
EU - Europa 6
PT - Portogallo 6
AU - Australia 5
AR - Argentina 4
JP - Giappone 3
LT - Lituania 3
RO - Romania 3
BO - Bolivia 2
DK - Danimarca 2
EG - Egitto 2
GR - Grecia 2
IR - Iran 2
MU - Mauritius 2
TN - Tunisia 2
TW - Taiwan 2
AT - Austria 1
BS - Bahamas 1
CL - Cile 1
CM - Camerun 1
CO - Colombia 1
CZ - Repubblica Ceca 1
GT - Guatemala 1
HU - Ungheria 1
IQ - Iraq 1
MX - Messico 1
NZ - Nuova Zelanda 1
PH - Filippine 1
SA - Arabia Saudita 1
TH - Thailandia 1
ZA - Sudafrica 1
Totale 18.126
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Città #
Warsaw 4.102
Fairfield 1.217
Dublin 803
Chandler 787
Jacksonville 630
Woodbridge 562
Ashburn 553
Cambridge 513
Houston 464
Seattle 459
Wilmington 403
Princeton 211
Singapore 208
Hong Kong 207
Florence 199
Ann Arbor 187
Altamura 161
Boston 153
Dong Ket 145
Lawrence 137
Buffalo 135
Boardman 134
Mumbai 104
Beijing 93
Medford 76
San Diego 74
Bremen 50
Rome 49
Shanghai 46
Santa Clara 44
Izmir 43
Norwalk 38
Milan 36
West Jordan 36
Falls Church 33
Los Angeles 31
New York 30
Moscow 29
Auburn Hills 28
Barcelona 25
Kent 22
Hillsboro 21
Phoenix 20
Bern 19
Frankfurt Am Main 19
Andover 18
Dearborn 17
Helsinki 15
Salerno 15
Pune 12
Toronto 12
Verona 11
London 10
Brussels 9
Redwood City 9
Seongnam 9
Tappahannock 8
Santa Maria A Monte 7
Cascina 6
Laurel 6
Sofia 6
Usingen 6
Berlin 5
Chicago 5
Fiesole 5
Guangzhou 5
Nagold 5
Naples 5
Porto Alegre 5
Tianjin 5
Zola Predosa 5
Buenos Aires 4
Chieti 4
Naaldwijk 4
Ottawa 4
Paris 4
San Lazzaro Di Savena 4
Scandicci 4
Toulouse 4
Bursa 3
Cagliari 3
Castelliri 3
Cecina 3
Evora 3
Madrid 3
Napoli 3
Orenburg 3
Parma 3
Philadelphia 3
Pisa 3
Porto 3
Redmond 3
Saint Petersburg 3
Valencia 3
Vicenza 3
Asti 2
Belluno 2
Bucharest 2
Cairo 2
Central 2
Totale 13.647
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Nome #
Uso della oleuropeina e suoi derivati nel trattamento del diabete mellito di tipo 2 e di patologie associate a fenomeni di aggregazione di proteine 263
Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes 255
Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: A mechanistic insight 251
Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes 251
A causative link between the structure of aberrant protein oligomers and their toxicity 247
Oleuropein Aglycone: A Possible Drug against Degenerative Conditions. In Vivo Evidence of its Effectiveness against Alzheimer's Disease 246
Properties of N-terminus truncated and C-terminus mutated muscle acylphosphatases. 245
Seladin-1/dhcr24 protects neuroblastoma cells against aβ toxicity by increasing membrane cholesterol content 241
The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology 240
proteomic analysis of cells exposed to prefibrillar aggregates of HypF-N 237
Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus 237
Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates 237
Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds 233
Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregates. 229
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases 228
Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin 219
Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy 219
Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload 216
Toxic HypF-N oligomers selectively bind the plasma membrane to impair cell adhesion capability 198
Employing AD animal models for translational research: focus on dietary components 198
Oleuropein aglycone protects against MAO-A-induced autophagy impairment and cardiomyocyte death through activation of TFEB. 196
Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers 195
Thermodynamics and kinetics of folding of common type acylphosphatase 189
The complete amino acid sequence of the low molecular weight cytosolic acid phosphatase 188
Oleuropein aglycone protects transgenic C. elegans strains expressing Abeta42 by reducing plauqe load and motor deficit 183
Looking for residues involved in the muscle acylphosphatase catalytic mechanism and structural stabilization: role of Asn41, Ther42 and Thr46 181
null 181
Nutraceutical properties of olive oli polyphenols. An itinerary from cultured cells through animal models to humans 174
Single particle tracking to study the binding of protein misfolded oligomer to membrane ganglioside GM1 171
Molecular links between aberrant protein oligomers and neurodegeneration in Alzheimer’s disease 167
null 154
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo 142
The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study 140
The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies 131
Crystal structure and anion binding in the prokaryotic hydrogenase maturation factor HypF acylphosphatase-like domain. 130
The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies 127
Aspartic-129 is an essential residue in the catalytic mechanism of the low M(r) phosphotyrosine protein phosphatase 124
1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity 123
1,2,4-trihydroxynapthalene-2-O-b-D-glucopyranoside: A new powerful antioxidant and inhibitor of Ab42 aggregation isolated from the leaves of Lawsonia inermis 120
Olive oil polyphenols can be useful to prevent aging-associated neurodegeneration 119
A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes 114
S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset 112
Differentiation increases the resistance of neuronal cells to amyloid toxicity 109
Olive polyphenols: new promising agents to combat aging-associated neurodegeneration 108
Affinity chromatographic purification of horse muscle acylphosphatase: evidence of the existence of multiple molecular forms. 106
Acylphosphatase from human skeletal muscle: purification, some properties and levels in normal and myopathic muscles 106
Assessing the role of aromatic residues in the amyloid aggregation of human muscle acylphosphatase 104
Amyloid aggregation: role of biological membranes and the aggregate-membrane system 103
Healthy Effects of Plant Polyphenols: Molecular Mechanisms 102
Arg23 is involved in the catalytic site of muscle acylphosphatase. 101
Expression, purification and preliminary crystal analysis of the human low Mr phosphotyrosine protein phosphatase isoform 1. 100
CA2+-ATPASE FROM SARCOPLASMIC RETICULUM: ACYLPHOSPHATASE ACTIVITY 99
CRYSTALLISATION OF A LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE FROM BOVINE LIVER. 99
Nonspecific interaction of prefibrillar amyloid aggregates with glutamatergic receptors results in Ca2+ increase in primary neuronal cells 98
Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils. 98
C-terminal region contributes to muscle acylphosphatase three-dimensional structure stabilisation 98
The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless to their aggregation state 97
Effect of acylphosphates on Ca2+ uptake by sarcoplasmic reticulum vesicles. 97
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers 97
Nutraceutical properties of olive oil polyphenols. An itinerary from cultured cells through animal models to humans 96
Biological function in a non-native partially folded state of a protein. 94
The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity 94
Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology 94
Equilibrium unfolding studies of horse muscle acylphosphatase. 93
Rabbit skeletal muscle acylphosphatase: the amino acid sequence of form Ra1. 92
Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation. 92
Preparation and some properties of a dimeric form (S-S) of horse muscle acylphosphatase 92
Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity. 92
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding. 91
Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ 1-42 aggregation 91
A protective role for lipid raft cholesterol againsy amyloid-induced membrane damage in human neuroblastoma cells 91
Rationalization of the effects of mutations on peptide and protein aggregation rates 90
Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicity 89
Natively folded HypF-N and its early amyloid aggregates interact with phospholipid monolayers and destabilize supported phospholipid bilayers 89
Purification and characterization of rabbit muscle acylphosphatase in the thiol (-SH) form. 89
Antisense peptides to 43-57 region of acylphosphatase and to 46-60 region of two isoenzymes of a low Mr PTPase do not interact with the corresponding proteins. 87
Investigating the effects of mutations on protein aggregation in the cell. 87
Three-dimensional structural characterization of a novel Drosophila melanogaster acylphosphatase. 87
Acylphosphatase increases the rate of ethanol production from glucose in cell-free extract of Saccharomyces cerevisiae 86
Different ataxin-3 amyloid aggregates induce intracellular Ca2+ deregulation by different mechanisms in cerebellar granule cells 86
Prefibrillar amyloid aggregates could be generic toxins in higher organisms 86
Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin 86
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases 85
Conformational stability of muscle acylphosphatase: the role of temperature, denaturant concentration and pH 84
Prefibrillar amyloid protein aggregates share common features of cytotoxicity 83
The primary structure of turkey muscle acylphosphatase. 82
Interactions of lysozyme with phospholipid vesicles: effects of vesicle biophysical features on protein misfolding and aggregation 82
Oleuropein aglycone counteracts Aβ42 toxicity in the rat brain 82
Generic cell dysfunction in neurodegenerative disorders: role of surfaces in early protein misfolding, aggregation and aggregate cytotoxicity. 81
Protein folding and misfolding. relevance to disease and to biological function 81
Horse brain acylphosphatase: purification and characterization 81
Disaggregation experiments as a tool to detect protofibrillar intermediates 80
Toxicity in amyloid diseases 79
Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world 79
Differing molecular mechanisms appear to underlie early toxicity of pre-fibrillar HypF-N aggregates to different cell types 79
Reversal of protein aggregation provides evidence for multiple aggregated states 79
Insights into acylphosphatase structure and catalytic mechanism. 78
Kinetic partitioning of protein folding and aggregation 78
Aggregation of the acylphosphatase from S. solfataricus. The folded and partially unfolded states can be both precursors for amyloid formation. 78
Hydrolysis by horse muscle acylphosphatase of (Ca2+ + Mg2+)-ATPase phosphorylated intermediate. 77
Totale 13.295
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Categoria #
all - tutte 46.226
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.226
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.984 0 0 120 321 394 422 324 491 309 208 335 60
2020/20212.724 210 225 201 299 96 324 99 247 188 398 125 312
2021/20221.363 56 132 79 58 73 55 61 88 75 59 304 323
2022/20233.372 346 445 162 338 269 639 478 169 354 11 115 46
2023/20241.163 48 145 204 67 74 173 32 241 20 64 41 54
2024/20251.422 267 834 321 0 0 0 0 0 0 0 0 0
Totale 18.307